The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ccr1  -  chemokine (C-C motif) receptor 1

Mus musculus

Synonyms: C-C CKR-1, C-C chemokine receptor type 1, CC-CKR-1, CCR-1, CCR1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ccr1


High impact information on Ccr1

  • SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion [5].
  • Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+ subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasite Toxoplasma gondii [6].
  • CC chemokine receptor 1 (CCR1) is expressed in neutrophils, monocytes, lymphocytes, and eosinophils, and binds the leukocyte chemoattractant and hematopoiesis regulator macrophage inflammatory protein (MIP)-1alpha, as well as several related CC chemokines [7].
  • This was associated with increased interferon-gamma and decreased interleukin-4 production in -/- versus +/+ lung lymph node cells stimulated with egg-specific antigen, suggesting that CCR1 influences the inflammatory response not only through direct effects on leukocyte chemotaxis, but also through effects on the type 1-type 2 cytokine balance [7].
  • To test the role of CCR1 in granuloma formation, we injected Schistosoma mansoni eggs intravenously, and observed a 40% reduction in the size of lung granulomas in -/- mice compared to +/+ littermates [7].

Chemical compound and disease context of Ccr1


Biological context of Ccr1


Anatomical context of Ccr1

  • In conclusion, these in vivo data demonstrate that Ccr1, Ccr2, and Ccr5 mediate the postischemic recruitment of neutrophils through effects on intravascular adherence and subsequent transmigration [1].
  • Conversely, plaque area, T cell, and interferon-gamma content were increased in ApoE-/- Ccr1-/- mice [16].
  • In fact, when CCR1 was blocked with BL5923, a novel orally available CCR1 antagonist, the interstitial recruitment of ex vivo labeled macrophages was markedly decreased in uninephrectomized male db/db mice with advanced diabetic nephropathy [2].
  • CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts [17].
  • CONCLUSION: These data implicate specific CCR and their ligands in regulation of the dendritic cell constituency of the kidney [18].

Associations of Ccr1 with chemical compounds


Physical interactions of Ccr1


Regulatory relationships of Ccr1

  • MATERIALS AND METHODS: CC chemokine receptor (CCR) mRNA expression was analyzed during OC formation induced by RANKL in murine RAW 264.7 cells and primary marrow cells [17].
  • In this study, CCR7 mRNA was proved to be expressed in DCs and their precursors derived from murine bone marrow-derived hematopoietic progenitor cells (HPCs), whereas CCR1 mRNA was expressed in both CD11b-/dullCD11c+ and CD11b+hiCD11c+ DC precursors [23].
  • Peritoneal macrophages isolated from naive CCR1(-/-) mice clearly demonstrated enhanced cytokine/chemokine generation and antibacterial responses compared with similarly treated WT macrophages [24].
  • However, the addition of TLR ligands inhibited IL-10-induced expression of CCR1 and CCR5 [25].
  • Moreover, they also indicate that CCR1 exacerbates L. major infection in C57BL/6 mice by up-regulating Th2-like response rather than inhibiting Th1 development or/and influencing leucocyte chemotaxis [26].

Other interactions of Ccr1

  • Already after 5 min of reperfusion, this increase was reduced significantly in Ccr1-/- and Ccr5-/- mice, whereas only in Ccr2-/- mice, was adherence attenuated significantly at 120 min after onset of reperfusion [1].
  • These findings led us to use Met-RANTES, a selective CCR1 and CCR5 antagonist, to modulate the acute T cruzi-elicited myocarditis [27].
  • Different strains of ApoE-/- Ccr5-/- mice, ApoE-/- Ccr1-/- mice or respective littermates, were fed a high-fat diet for 10 to 12 weeks [16].
  • The model of progressive immune complex glomerulonephritis in autoimmune MRL(lpr/lpr) mice was used to evaluate whether chemokine receptor CCR1 blockade late in the disease course can affect progression to renal failure [3].
  • In contrast, only the messages encoding SDF-1alpha (now known as Sdf1) and Ccr1 were elevated 26 weeks postirradiation in fibrosis-resistant (C3H/HeJ) mice [28].

Analytical, diagnostic and therapeutic context of Ccr1


  1. Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue. Reichel, C.A., Khandoga, A., Anders, H.J., Schlöndorff, D., Luckow, B., Krombach, F. J. Leukoc. Biol. (2006) [Pubmed]
  2. The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice. Ninichuk, V., Khandoga, A.G., Segerer, S., Loetscher, P., Schlapbach, A., Revesz, L., Feifel, R., Khandoga, A., Krombach, F., Nelson, P.J., Schlöndorff, D., Anders, H.J. Am. J. Pathol. (2007) [Pubmed]
  3. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. Anders, H.J., Belemezova, E., Eis, V., Segerer, S., Vielhauer, V., Perez de Lema, G., Kretzler, M., Cohen, C.D., Frink, M., Horuk, R., Hudkins, K.L., Alpers, C.E., Mampaso, F., Schlöndorff, D. J. Am. Soc. Nephrol. (2004) [Pubmed]
  4. Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. Anders, H.J., Vielhauer, V., Kretzler, M., Cohen, C.D., Segerer, S., Luckow, B., Weller, L., Gröne, H.J., Schlöndorff, D. J. Am. Soc. Nephrol. (2001) [Pubmed]
  5. SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion. Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, N., Taketo, M.M. Nat. Genet. (2007) [Pubmed]
  6. CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells. Aliberti, J., Reis e Sousa, C., Schito, M., Hieny, S., Wells, T., Huffnagle, G.B., Sher, A. Nat. Immunol. (2000) [Pubmed]
  7. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. Gao, J.L., Wynn, T.A., Chang, Y., Lee, E.J., Broxmeyer, H.E., Cooper, S., Tiffany, H.L., Westphal, H., Kwon-Chung, J., Murphy, P.M. J. Exp. Med. (1997) [Pubmed]
  8. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Vielhauer, V., Berning, E., Eis, V., Kretzler, M., Segerer, S., Strutz, F., Horuk, R., Gröne, H.J., Schlöndorff, D., Anders, H.J. Kidney Int. (2004) [Pubmed]
  9. Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. Topham, P.S., Csizmadia, V., Soler, D., Hines, D., Gerard, C.J., Salant, D.J., Hancock, W.W. J. Clin. Invest. (1999) [Pubmed]
  10. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Rottman, J.B., Slavin, A.J., Silva, R., Weiner, H.L., Gerard, C.G., Hancock, W.W. Eur. J. Immunol. (2000) [Pubmed]
  11. Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice. Tokuda, A., Itakura, M., Onai, N., Kimura, H., Kuriyama, T., Matsushima, K. J. Immunol. (2000) [Pubmed]
  12. Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9. Kozak, C.A., Gao, J.L., Murphy, P.M. Genomics (1995) [Pubmed]
  13. Estrogen regulates CCR gene expression and function in T lymphocytes. Mo, R., Chen, J., Grolleau-Julius, A., Murphy, H.S., Richardson, B.C., Yung, R.L. J. Immunol. (2005) [Pubmed]
  14. The contribution of chemokines and chemokine receptors to the rejection of fetal proislet allografts. Solomon, M.F., Kuziel, W.A., Simeonovic, C.J. Cell transplantation. (2004) [Pubmed]
  15. Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. Miyazaki, D., Nakamura, T., Toda, M., Cheung-Chau, K.W., Richardson, R.M., Ono, S.J. J. Clin. Invest. (2005) [Pubmed]
  16. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Braunersreuther, V., Zernecke, A., Arnaud, C., Liehn, E.A., Steffens, S., Shagdarsuren, E., Bidzhekov, K., Burger, F., Pelli, G., Luckow, B., Mach, F., Weber, C. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  17. CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts. Yu, X., Huang, Y., Collin-Osdoby, P., Osdoby, P. J. Bone Miner. Res. (2004) [Pubmed]
  18. CCR and CC chemokine expression in relation to Flt3 ligand-induced renal dendritic cell mobilization. Coates, P.T., Colvin, B.L., Ranganathan, A., Duncan, F.J., Lan, Y.Y., Shufesky, W.J., Zahorchak, A.F., Morelli, A.E., Thomson, A.W. Kidney Int. (2004) [Pubmed]
  19. MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4. Ramos, C.D., Canetti, C., Souto, J.T., Silva, J.S., Hogaboam, C.M., Ferreira, S.H., Cunha, F.Q. J. Leukoc. Biol. (2005) [Pubmed]
  20. Attenuation of osteoclastogenesis and osteoclast function by apigenin. Bandyopadhyay, S., Lion, J.M., Mentaverri, R., Ricupero, D.A., Kamel, S., Romero, J.R., Chattopadhyay, N. Biochem. Pharmacol. (2006) [Pubmed]
  21. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. Gao, W., Topham, P.S., King, J.A., Smiley, S.T., Csizmadia, V., Lu, B., Gerard, C.J., Hancock, W.W. J. Clin. Invest. (2000) [Pubmed]
  22. Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Dambach, D.M., Watson, L.M., Gray, K.R., Durham, S.K., Laskin, D.L. Hepatology (2002) [Pubmed]
  23. Chemotactic response toward chemokines and its regulation by transforming growth factor-beta1 of murine bone marrow hematopoietic progenitor cell-derived different subset of dendritic cells. Ogata, M., Zhang, Y., Wang, Y., Itakura, M., Zhang, Y.Y., Harada, A., Hashimoto, S., Matsushima, K. Blood (1999) [Pubmed]
  24. CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. Ness, T.L., Carpenter, K.J., Ewing, J.L., Gerard, C.J., Hogaboam, C.M., Kunkel, S.L. J. Immunol. (2004) [Pubmed]
  25. Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. Fernandez, S., Jose, P., Avdiushko, M.G., Kaplan, A.M., Cohen, D.A. J. Immunol. (2004) [Pubmed]
  26. CC chemokine receptor 1 enhances susceptibility to Leishmania major during early phase of infection. Rodriguez-Sosa, M., Rosas, L.E., Terrazas, L.I., Lu, B., Gerard, C., Satoskar, A.R. Immunol. Cell Biol. (2003) [Pubmed]
  27. Regulated on activation, normal T cell expressed and secreted (RANTES) antagonist (Met-RANTES) controls the early phase of Trypanosoma cruzi-elicited myocarditis. Marino, A.P., da Silva, A., dos Santos, P., Pinto, L.M., Gazzinelli, R.T., Teixeira, M.M., Lannes-Vieira, J. Circulation (2004) [Pubmed]
  28. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Johnston, C.J., Williams, J.P., Okunieff, P., Finkelstein, J.N. Radiat. Res. (2002) [Pubmed]
  29. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. Zhao, X., Sato, A., Dela Cruz, C.S., Linehan, M., Luegering, A., Kucharzik, T., Shirakawa, A.K., Marquez, G., Farber, J.M., Williams, I., Iwasaki, A. J. Immunol. (2003) [Pubmed]
  30. Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease. Blease, K., Mehrad, B., Standiford, T.J., Lukacs, N.W., Kunkel, S.L., Chensue, S.W., Lu, B., Gerard, C.J., Hogaboam, C.M. J. Immunol. (2000) [Pubmed]
  31. Murine astrocytes express a functional chemokine receptor. Tanabe, S., Heesen, M., Berman, M.A., Fischer, M.B., Yoshizawa, I., Luo, Y., Dorf, M.E. J. Neurosci. (1997) [Pubmed]
WikiGenes - Universities