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Pdcd1lg2  -  programmed cell death 1 ligand 2

Mus musculus

Synonyms: B7-DC, B7dc, Btdc, Butyrophilin B7-DC, Cd273, ...
 
 
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Disease relevance of Pdcd1lg2

 

High impact information on Pdcd1lg2

  • These results highlight the contrasting in vivo roles of B7-DC and B7-H1 and indicate that B7-DC functions as a tuning molecule, selectively augmenting T helper 1 and CTL responses [6].
  • Hepatic tumors grew more quickly in B7-DC KO mice, associated with a decrease in intrahepatic tumor-specific CD8 T cells [6].
  • In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses [6].
  • This loss of APC function correlates with a reduced expression of costimulatory molecules, including programmed cell death ligand (PD-L)1, PD-L2, CD40, CD80, CD86, and inducible T cell costimulator, and of major histocompatibility complex class II on CD11c(+ )APCs from the airways of ISS-treated mice [7].
  • Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor [8].
 

Biological context of Pdcd1lg2

 

Anatomical context of Pdcd1lg2

 

Associations of Pdcd1lg2 with chemical compounds

 

Regulatory relationships of Pdcd1lg2

 

Other interactions of Pdcd1lg2

  • B6 mice immunized with MOG35-55 developed chronic persistent EAE, and PD-L2 blockade in the chronic phase exacerbated EAE, whereas PD-L1 blockade did not [1].
  • Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells [15].
  • Additionally, IL-4 increased cell surface expression of B7-DC in both immature and mature DCs [17].
  • In this study, cross-linking B7-DC with the monoclonal antibody sHIgM12 directly potentiates dendritic cell (DC) function by enhancing DC presentation of major histocompatibility complex-peptide complexes, promoting DC survival; and increasing secretion of interleukin (IL)-12p70, a key T helper cell type 1 promoting cytokine [15].
  • PD-L1 up-regulation depends on TLR4 and STAT1, whereas PD-L2 expression depends on IL-4R alpha and STAT6 [18].
 

Analytical, diagnostic and therapeutic context of Pdcd1lg2

  • RT-PCR and real-time PCR revealed that both PD-L1 and PD-L2 genes were expressed in tumor and vicinal muscle tissues of tumor-bearing mice and the expression level was significantly increased if a higher dosage of pSLC was administered [19].
  • The parallel signaling events induced in human and mouse DC demonstrate that activation of cells using IgM Ab results in a response governed by a common mechanism and support the hypothesis that B7-DC cross-linking using this Ab may provide beneficial therapeutic immune modulation in human patients similar to those seen in animal models [20].
  • CONCLUSION: Activation of DCs with B7-DC XAb ex vivo before adoptive transfer into presensitized mice is sufficient to protect animals completely from inflammatory lung disease induced by subsequent repeated airway exposure to the offending antigen [21].

References

  1. Differential role of programmed death-ligand 1 and programmed death-ligand 2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. Zhu, B., Guleria, I., Khosroshahi, A., Chitnis, T., Imitola, J., Azuma, M., Yagita, H., Sayegh, M.H., Khoury, S.J. J. Immunol. (2006) [Pubmed]
  2. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. Matsumoto, K., Inoue, H., Nakano, T., Tsuda, M., Yoshiura, Y., Fukuyama, S., Tsushima, F., Hoshino, T., Aizawa, H., Akiba, H., Pardoll, D., Hara, N., Yagita, H., Azuma, M., Nakanishi, Y. J. Immunol. (2004) [Pubmed]
  3. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Liang, S.C., Greenwald, R.J., Latchman, Y.E., Rosas, L., Satoskar, A., Freeman, G.J., Sharpe, A.H. Eur. J. Immunol. (2006) [Pubmed]
  4. Bacterial probiotic modulation of dendritic cells. Drakes, M., Blanchard, T., Czinn, S. Infect. Immun. (2004) [Pubmed]
  5. Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice. Fukushima, A., Yamaguchi, T., Azuma, M., Yagita, H., Ueno, H. The British journal of ophthalmology. (2006) [Pubmed]
  6. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. Shin, T., Yoshimura, K., Shin, T., Crafton, E.B., Tsuchiya, H., Housseau, F., Koseki, H., Schulick, R.D., Chen, L., Pardoll, D.M. J. Exp. Med. (2005) [Pubmed]
  7. Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction. Hessel, E.M., Chu, M., Lizcano, J.O., Chang, B., Herman, N., Kell, S.A., Wills-Karp, M., Coffman, R.L. J. Exp. Med. (2005) [Pubmed]
  8. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. Shin, T., Kennedy, G., Gorski, K., Tsuchiya, H., Koseki, H., Azuma, M., Yagita, H., Chen, L., Powell, J., Pardoll, D., Housseau, F. J. Exp. Med. (2003) [Pubmed]
  9. Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. Radhakrishnan, S., Nguyen, L.T., Ciric, B., Ure, D.R., Zhou, B., Tamada, K., Dong, H., Tseng, S.Y., Shin, T., Pardoll, D.M., Chen, L., Kyle, R.A., Rodriguez, M., Pease, L.R. J. Immunol. (2003) [Pubmed]
  10. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Liang, S.C., Latchman, Y.E., Buhlmann, J.E., Tomczak, M.F., Horwitz, B.H., Freeman, G.J., Sharpe, A.H. Eur. J. Immunol. (2003) [Pubmed]
  11. Mycophenolic acid upregulates B7-DC expression on dendritic cells, which is associated with impaired allostimulatory capacity of dendritic cells. Geng, L., Jiang, G., Xie, H., Fang, Y., Dong, S., Chen, Y., Shen, M., Zheng, S. Transplant. Proc. (2006) [Pubmed]
  12. B7-DC cross-linking restores antigen uptake and augments antigen-presenting cell function by matured dendritic cells. Radhakrishnan, S., Celis, E., Pease, L.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. Liu, X., Gao, J.X., Wen, J., Yin, L., Li, O., Zuo, T., Gajewski, T.F., Fu, Y.X., Zheng, P., Liu, Y. J. Exp. Med. (2003) [Pubmed]
  14. Expression of programmed death 1 ligands by murine T cells and APC. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D.M., Okumura, K., Azuma, M., Yagita, H. J. Immunol. (2002) [Pubmed]
  15. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. Nguyen, L.T., Radhakrishnan, S., Ciric, B., Tamada, K., Shin, T., Pardoll, D.M., Chen, L., Rodriguez, M., Pease, L.R. J. Exp. Med. (2002) [Pubmed]
  16. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. Wang, S., Bajorath, J., Flies, D.B., Dong, H., Honjo, T., Chen, L. J. Exp. Med. (2003) [Pubmed]
  17. A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer. Gorski, K.S., Shin, T., Crafton, E., Otsuji, M., Rattis, F.M., Huang, X., Kelleher, E., Francisco, L., Pardoll, D., Tsuchiya, H. Mol. Immunol. (2003) [Pubmed]
  18. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Loke, P., Allison, J.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  19. Blocking programmed death-1 ligand-PD-1 interactions by local gene therapy results in enhancement of antitumor effect of secondary lymphoid tissue chemokine. He, Y.F., Zhang, G.M., Wang, X.H., Zhang, H., Yuan, Y., Li, D., Feng, Z.H. J. Immunol. (2004) [Pubmed]
  20. B7-DC/PD-L2 Cross-Linking Induces NF-{kappa}B-Dependent Protection of Dendritic Cells from Cell Death. Radhakrishnan, S., Nguyen, L.T., Ciric, B., Van Keulen, V.P., Pease, L.R. J. Immunol. (2007) [Pubmed]
  21. Dendritic cells activated by cross-linking B7-DC (PD-L2) block inflammatory airway disease. Radhakrishnan, S., Iijima, K., Kobayashi, T., Kita, H., Pease, L.R. J. Allergy Clin. Immunol. (2005) [Pubmed]
 
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