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Gene Review

Il4ra  -  interleukin 4 receptor, alpha

Mus musculus

Synonyms: CD124, IL-4 receptor alpha chain, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, ...
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Disease relevance of Il4ra


High impact information on Il4ra


Chemical compound and disease context of Il4ra


Biological context of Il4ra


Anatomical context of Il4ra


Associations of Il4ra with chemical compounds

  • Also, simvastatin was unable to augment Ym1 expression in DCs developed from STAT6-/- or IL-4R alpha-/- mice [20].
  • Although IL-4R alpha signals Shc and SH2-containing inositol phosphatase (SHIP) phosphorylation, we could not establish an association between their activation and protection from apoptosis [21].

Regulatory relationships of Il4ra

  • Unexpectedly, during L. major infection, isolated CD4(+) IL-4Ralpha(-/-) T cells expressed high IL-4- but low gamma interferon (IFN-gamma)-specific mRNA, comparable to Th2-polarized BALB/c CD4(+) cells and in contrast to Th1-polarized C57BL/6 CD4(+) cells [22].
  • IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung [23].
  • IL-4 signaling through IL-4R alpha/gamma(c) suppresses Ca2T6 and SPRR gene expression in normal mice and induces these genes in RAG2/gamma(c)-deficient mice [24].

Other interactions of Il4ra


Analytical, diagnostic and therapeutic context of Il4ra


  1. Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Barner, M., Mohrs, M., Brombacher, F., Kopf, M. Curr. Biol. (1998) [Pubmed]
  2. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Yang, M., Hogan, S.P., Henry, P.J., Matthaei, K.I., McKenzie, A.N., Young, I.G., Rothenberg, M.E., Foster, P.S. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  3. Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice. Saeftel, M., Krueger, A., Arriens, S., Heussler, V., Racz, P., Fleischer, B., Brombacher, F., Hoerauf, A. Infect. Immun. (2004) [Pubmed]
  4. Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. Mohrs, M., Ledermann, B., Köhler, G., Dorfmüller, A., Gessner, A., Brombacher, F. J. Immunol. (1999) [Pubmed]
  5. IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains. Noben-Trauth, N., Paul, W.E., Sacks, D.L. J. Immunol. (1999) [Pubmed]
  6. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Herbert, D.R., Hölscher, C., Mohrs, M., Arendse, B., Schwegmann, A., Radwanska, M., Leeto, M., Kirsch, R., Hall, P., Mossmann, H., Claussen, B., Förster, I., Brombacher, F. Immunity (2004) [Pubmed]
  7. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Urban, J.F., Noben-Trauth, N., Donaldson, D.D., Madden, K.B., Morris, S.C., Collins, M., Finkelman, F.D. Immunity (1998) [Pubmed]
  8. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain. Wang, H.Y., Paul, W.E., Keegan, A.D. Immunity (1996) [Pubmed]
  9. Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. Terabe, M., Matsui, S., Park, J.M., Mamura, M., Noben-Trauth, N., Donaldson, D.D., Chen, W., Wahl, S.M., Ledbetter, S., Pratt, B., Letterio, J.J., Paul, W.E., Berzofsky, J.A. J. Exp. Med. (2003) [Pubmed]
  10. Transient inhibition of interleukin 4 signaling by T cell receptor ligation. Zhu, J., Huang, H., Guo, L., Stonehouse, T., Watson, C.J., Hu-Li, J., Paul, W.E. J. Exp. Med. (2000) [Pubmed]
  11. Mechanistic analysis of experimental food allergen-induced cutaneous reactions. Prescott, V.E., Forbes, E., Foster, P.S., Matthaei, K., Hogan, S.P. J. Leukoc. Biol. (2006) [Pubmed]
  12. Signaling via interleukin-4 receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice. Mountford, A.P., Hogg, K.G., Coulson, P.S., Brombacher, F. Infect. Immun. (2001) [Pubmed]
  13. X-SCID B cell responses to interleukin-4 and interleukin-13 are mediated by a receptor complex that includes the interleukin-4 receptor alpha chain (p140) but not the gamma c chain. Matthews, D.J., Hibbert, L., Friedrich, K., Minty, A., Callard, R.E. Eur. J. Immunol. (1997) [Pubmed]
  14. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Loke, P., Allison, J.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene. Chen, Y., Rosloniec, E., Goral, M.I., Boothby, M., Chen, J. J. Immunol. (2001) [Pubmed]
  16. Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes. Stephenson, L.M., Park, D.S., Mora, A.L., Goenka, S., Boothby, M. J. Immunol. (2005) [Pubmed]
  17. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Cao, Y., Brombacher, F., Tunyogi-Csapo, M., Glant, T.T., Finnegan, A. Arthritis Rheum. (2007) [Pubmed]
  18. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Noben-Trauth, N., Shultz, L.D., Brombacher, F., Urban, J.F., Gu, H., Paul, W.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  19. New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines. Mora, A.L., Stephenson, L.M., Enerson, B., Youn, J., Keegan, A.D., Boothby, M. J. Immunol. (2003) [Pubmed]
  20. Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Arora, M., Chen, L., Paglia, M., Gallagher, I., Allen, J.E., Vyas, Y.M., Ray, A., Ray, P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  21. Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis. Zamorano, J., Keegan, A.D. J. Immunol. (1998) [Pubmed]
  22. Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection. Mohrs, M., Holscher, C., Brombacher, F. Infect. Immun. (2000) [Pubmed]
  23. IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. Mattes, J., Yang, M., Siqueira, A., Clark, K., MacKenzie, J., McKenzie, A.N., Webb, D.C., Matthaei, K.I., Foster, P.S. J. Immunol. (2001) [Pubmed]
  24. Suppressive effect of IL-4 on IL-13-induced genes in mouse lung. Finkelman, F.D., Yang, M., Perkins, C., Schleifer, K., Sproles, A., Santeliz, J., Bernstein, J.A., Rothenberg, M.E., Morris, S.C., Wills-Karp, M. J. Immunol. (2005) [Pubmed]
  25. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains. Zhang, J.G., Hilton, D.J., Willson, T.A., McFarlane, C., Roberts, B.A., Moritz, R.L., Simpson, R.J., Alexander, W.S., Metcalf, D., Nicola, N.A. J. Biol. Chem. (1997) [Pubmed]
  26. Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation: a comparative study. Pousset, F., Cremona, S., Dantzer, R., Kelley, K., Parnet, P. Glia (1999) [Pubmed]
  27. The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major. Noben-Trauth, N., Lira, R., Nagase, H., Paul, W.E., Sacks, D.L. J. Immunol. (2003) [Pubmed]
  28. Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF. Lutz, M.B., Schnare, M., Menges, M., Rössner, S., Röllinghoff, M., Schuler, G., Gessner, A. J. Immunol. (2002) [Pubmed]
  29. Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts. McGaha, T.L., Le, M., Kodera, T., Stoica, C., Zhu, J., Paul, W.E., Bona, C.A. Arthritis Rheum. (2003) [Pubmed]
  30. Adoptive transfer of CD4+ T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin-4 (IL-4)/IL-13 receptor signaling. Lucas, B., Bumann, D., Walduck, A., Koesling, J., Develioglu, L., Meyer, T.F., Aebischer, T. Infect. Immun. (2001) [Pubmed]
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