Gene Review:
NR1I2 - nuclear receptor subfamily 1, group I,...
Homo sapiens
Synonyms:
BXR, Nuclear receptor subfamily 1 group I member 2, ONR1, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, ...
Nguyen,
Yokoyama,
Walrant-Debray,
Tateishi,
Owen,
Tazawa,
Maurel,
Poso,
Ohnishi,
Chandler,
Back,
Segawa,
Suwaki,
Blumberg,
Pascussi,
Hiramatsu,
Nakatsukasa,
Tsujimoto,
Takagi,
Honkakoski,
Kullak-Ublick,
Sasano,
Vilarem,
Kodama,
Kudo,
Masuyama,
Becker,
Hiramatsu,
Martin,
Pineau,
Garabedian,
Miki,
Navarro,
Khoo,
Masuyama,
Saric,
Suzuki,
Robert,
Takara,
- RIFAMPICIN INDUCTION OF CYP3A4 REQUIRES PREGNANE X RECEPTOR CROSS TALK WITH HEPATOCYTE NUCLEAR FACTOR 4{alpha} AND COACTIVATORS, AND SUPPRESSION OF SMALL HETERODIMER PARTNER GENE EXPRESSION. Li, T., Chiang, J.Y. Drug Metab. Dispos. (2006)
- Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies. Poso, A., Honkakoski, P. Mini reviews in medicinal chemistry. (2006)
- The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. Dring, M.M., Goulding, C.A., Trimble, V.I., Keegan, D., Ryan, A.W., Brophy, K.M., Smyth, C.M., Keeling, P.W., O'Donoghue, D., O'Sullivan, M., O'Morain, C., Mahmud, N., Wikström, A.C., Kelleher, D., McManus, R. Gastroenterology (2006)
- Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. Pascussi, J.M., Robert, A., Nguyen, M., Walrant-Debray, O., Garabedian, M., Martin, P., Pineau, T., Saric, J., Navarro, F., Maurel, P., Vilarem, M.J. J. Clin. Invest. (2005)
- Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Stedman, C.A., Liddle, C., Coulter, S.A., Sonoda, J., Alvarez, J.G., Moore, D.D., Evans, R.M., Downes, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Gupta, D., Venkatesh, M., Wang, H., Kim, S., Sinz, M., Goldberg, G.L., Whitney, K., Longley, C., Mani, S. Clin. Cancer Res. (2008)
- TOLL-like receptors linking innate and adaptive immune response. Werling, D., Jungi, T.W. Vet. Immunol. Immunopathol. (2003)
- The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Tirona, R.G., Lee, W., Leake, B.F., Lan, L.B., Cline, C.B., Lamba, V., Parviz, F., Duncan, S.A., Inoue, Y., Gonzalez, F.J., Schuetz, E.G., Kim, R.B. Nat. Med. (2003)
- The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Synold, T.W., Dussault, I., Forman, B.M. Nat. Med. (2001)
- Humanized xenobiotic response in mice expressing nuclear receptor SXR. Xie, W., Barwick, J.L., Downes, M., Blumberg, B., Simon, C.M., Nelson, M.C., Neuschwander-Tetri, B.A., Brunt, E.M., Guzelian, P.S., Evans, R.M. Nature (2000)
- An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Expression and potential roles of pregnane X receptor in endometrial cancer. Masuyama, H., Hiramatsu, Y., Kodama, J., Kudo, T. J. Clin. Endocrinol. Metab. (2003)
- Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification. Misawa, A., Inoue, J., Sugino, Y., Hosoi, H., Sugimoto, T., Hosoda, F., Ohki, M., Imoto, I., Inazawa, J. Cancer Res. (2005)
- Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA. Takara, K., Takagi, K., Tsujimoto, M., Ohnishi, N., Yokoyama, T. Biochem. Biophys. Res. Commun. (2003)
- Physiology and pathophysiology of proteinase-activated receptors (PARs): role of tryptase/PAR-2 in vascular endothelial barrier function. Itoh, Y., Sendo, T., Oishi, R. J. Pharmacol. Sci. (2005)
- The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Lehmann, J.M., McKee, D.D., Watson, M.A., Willson, T.M., Moore, J.T., Kliewer, S.A. J. Clin. Invest. (1998)
- Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. Geick, A., Eichelbaum, M., Burk, O. J. Biol. Chem. (2001)
- The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Masuyama, H., Suwaki, N., Tateishi, Y., Nakatsukasa, H., Segawa, T., Hiramatsu, Y. Mol. Endocrinol. (2005)
- Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Ferguson, S.S., LeCluyse, E.L., Negishi, M., Goldstein, J.A. Mol. Pharmacol. (2002)
- In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation. Bauer, B., Yang, X., Hartz, A.M., Olson, E.R., Zhao, R., Kalvass, J.C., Pollack, G.M., Miller, D.S. Mol. Pharmacol. (2006)
- Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. Owen, A., Chandler, B., Back, D.J., Khoo, S.H. Antivir. Ther. (Lond.) (2004)
- Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. Wang, H., Faucette, S., Moore, R., Sueyoshi, T., Negishi, M., LeCluyse, E. J. Biol. Chem. (2004)
- Effects of budesonide on P-glycoprotein expression in intestinal cell lines. Maier, A., Zimmermann, C., Beglinger, C., Drewe, J., Gutmann, H. Br. J. Pharmacol. (2007)
- Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Moore, L.B., Parks, D.J., Jones, S.A., Bledsoe, R.K., Consler, T.G., Stimmel, J.B., Goodwin, B., Liddle, C., Blanchard, S.G., Willson, T.M., Collins, J.L., Kliewer, S.A. J. Biol. Chem. (2000)
- Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. Kast, H.R., Goodwin, B., Tarr, P.T., Jones, S.A., Anisfeld, A.M., Stoltz, C.M., Tontonoz, P., Kliewer, S., Willson, T.M., Edwards, P.A. J. Biol. Chem. (2002)
- Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. Moreau, A., Vilarem, M.J., Maurel, P., Pascussi, J.M. Mol. Pharm. (2008)
- CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver. Iwahori, T., Matsuura, T., Maehashi, H., Sugo, K., Saito, M., Hosokawa, M., Chiba, K., Masaki, T., Aizaki, H., Ohkawa, K., Suzuki, T. Hepatology (2003)
- Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator 1{alpha}. Itoh, M., Nakajima, M., Higashi, E., Yoshida, R., Nagata, K., Yamazoe, Y., Yokoi, T. J. Pharmacol. Exp. Ther. (2006)
- The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. Chen, Y., Kissling, G., Negishi, M., Goldstein, J.A. J. Pharmacol. Exp. Ther. (2005)
- Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. Watkins, R.E., Davis-Searles, P.R., Lambert, M.H., Redinbo, M.R. J. Mol. Biol. (2003)
- Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Goodwin, B., Moore, L.B., Stoltz, C.M., McKee, D.D., Kliewer, S.A. Mol. Pharmacol. (2001)
- The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Zhang, J., Kuehl, P., Green, E.D., Touchman, J.W., Watkins, P.B., Daly, A., Hall, S.D., Maurel, P., Relling, M., Brimer, C., Yasuda, K., Wrighton, S.A., Hancock, M., Kim, R.B., Strom, S., Thummel, K., Russell, C.G., Hudson, J.R., Schuetz, E.G., Boguski, M.S. Pharmacogenetics (2001)
- Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Li, T., Chiang, J.Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid. Kawai, M., Chen, J., Cheung, C.Y., Chang, T.K. Mol. Cell. Biochem. (2003)
- Sex is a major determinant of CYP3A4 expression in human liver. Wolbold, R., Klein, K., Burk, O., Nüssler, A.K., Neuhaus, P., Eichelbaum, M., Schwab, M., Zanger, U.M. Hepatology (2003)
- The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR). Burk, O., Koch, I., Raucy, J., Hustert, E., Eichelbaum, M., Brockmöller, J., Zanger, U.M., Wojnowski, L. J. Biol. Chem. (2004)
- Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Duret, C., Daujat-Chavanieu, M., Pascussi, J.M., Pichard-Garcia, L., Balaguer, P., Fabre, J.M., Vilarem, M.J., Maurel, P., Gerbal-Chaloin, S. Mol. Pharmacol. (2006)
- Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Lin, W., Wu, J., Dong, H., Bouck, D., Zeng, F.Y., Chen, T. J. Biol. Chem. (2008)
- Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Mani, S., Huang, H., Sundarababu, S., Liu, W., Kalpana, G., Smith, A.B., Horwitz, S.B. Clin. Cancer Res. (2005)
- Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Pascussi, J.M., Drocourt, L., Fabre, J.M., Maurel, P., Vilarem, M.J. Mol. Pharmacol. (2000)
- Regulation of drug and bile salt transporters in liver and intestine. Kullak-Ublick, G.A., Becker, M.B. Drug Metab. Rev. (2003)
- Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Miki, Y., Suzuki, T., Tazawa, C., Blumberg, B., Sasano, H. Mol. Cell. Endocrinol. (2005)