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Gene Review

Asph  -  aspartate-beta-hydroxylase

Mus musculus

Synonyms: 2310005F16Rik, 3110001L23Rik, AI848629, ASP beta-hydroxylase, AW261690, ...
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Disease relevance of Asph


High impact information on Asph


Biological context of Asph


Anatomical context of Asph


Associations of Asph with chemical compounds

  • The amplitude of caffeine-induced Ca(2+) transients was lower in cardiomyocytes from junctin-overexpressing mice [9].
  • The inactivation kinetics of L-type Ca(2+) channel were prolonged in junctin-overexpressing cardiomyocytes using Ca(2+) or Ba(2+) as charge carriers [9].

Other interactions of Asph

  • This critical region contains two known genes (Asph and Gfd6) and three predicted genes, all of which are positional candidates for Tcm [12].
  • Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin [1].
  • Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels [7].
  • Altogether, these results provide a new hypothesis concerning sperm TRPC2 gating: TRPC2 activation may be due to modifications of its interaction with both junctate and IP3R, induced by depletion of calcium from the acrosomal vesicle [7].
  • Triadin 1 overexpression was accompanied by time-dependent changes in the protein expression of the ryanodine receptor, junctin, and cardiac/slow-twitch muscle SR Ca(2+)-ATPase isoform [13].

Analytical, diagnostic and therapeutic context of Asph


  1. Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin. Hong, C.S., Cho, M.C., Kwak, Y.G., Song, C.H., Lee, Y.H., Lim, J.S., Kwon, Y.K., Chae, S.W., Kim, d.o. .H. FASEB J. (2002) [Pubmed]
  2. Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin. Kirchhefer, U., Baba, H.A., Hanske, G., Jones, L.R., Kirchhof, P., Schmitz, W., Neumann, J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  3. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Yuan, Q., Fan, G.C., Dong, M., Altschafl, B., Diwan, A., Ren, X., Hahn, H.H., Zhao, W., Waggoner, J.R., Jones, L.R., Jones, W.K., Bers, D.M., Dorn, G.W., Wang, H.S., Valdivia, H.H., Chu, G., Kranias, E.G. Circulation (2007) [Pubmed]
  4. Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX. Gronke, R.S., VanDusen, W.J., Garsky, V.M., Jacobs, J.W., Sardana, M.K., Stern, A.M., Friedman, P.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. Dinchuk, J.E., Focht, R.J., Kelley, J.A., Henderson, N.L., Zolotarjova, N.I., Wynn, R., Neff, N.T., Link, J., Huber, R.M., Burn, T.C., Rupar, M.J., Cunningham, M.R., Selling, B.H., Ma, J., Stern, A.A., Hollis, G.F., Stein, R.B., Friedman, P.A. J. Biol. Chem. (2002) [Pubmed]
  6. Purification, primary structure, and immunological characterization of the 26-kDa calsequestrin binding protein (junctin) from cardiac junctional sarcoplasmic reticulum. Jones, L.R., Zhang, L., Sanborn, K., Jorgensen, A.O., Kelley, J. J. Biol. Chem. (1995) [Pubmed]
  7. Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels. Stamboulian, S., Moutin, M.J., Treves, S., Pochon, N., Grunwald, D., Zorzato, F., De Waard, M., Ronjat, M., Arnoult, C. Dev. Biol. (2005) [Pubmed]
  8. Molecular cloning and characterization of mouse cardiac junctate isoforms. Hong, C.S., Kwak, Y.G., Ji, J.H., Chae, S.W., Kim, d.o. .H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  9. Impaired relaxation in transgenic mice overexpressing junctin. Kirchhefer, U., Neumann, J., Bers, D.M., Buchwalow, I.B., Fabritz, L., Hanske, G., Justus, I., Riemann, B., Schmitz, W., Jones, L.R. Cardiovasc. Res. (2003) [Pubmed]
  10. Junctin and calsequestrin overexpression in cardiac muscle: the role of junctin and the synthetic and delivery pathways for the two proteins. Tijskens, P., Jones, L.R., Franzini-Armstrong, C. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  11. Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. Kirchhefer, U., Hanske, G., Jones, L.R., Justus, I., Kaestner, L., Lipp, P., Schmitz, W., Neumann, J. Cell Calcium (2006) [Pubmed]
  12. Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. Wang, K.S., Zahn, L.E., Favor, J., Huang, K.M., Stambolian, D. Mamm. Genome (2005) [Pubmed]
  13. Altered function in atrium of transgenic mice overexpressing triadin 1. Kirchhefer, U., Baba, H.A., Kobayashi, Y.M., Jones, L.R., Schmitz, W., Neumann, J. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  14. Structural alterations in cardiac calcium release units resulting from overexpression of junctin. Zhang, L., Franzini-Armstrong, C., Ramesh, V., Jones, L.R. J. Mol. Cell. Cardiol. (2001) [Pubmed]
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