The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

LYNX1  -  Ly6/neurotoxin 1

Homo sapiens

Synonyms: Ly-6/neurotoxin-like protein 1, SLURP-2, SLURP2, Secreted Ly-6/uPAR domain-containing protein 2, Secreted Ly-6/uPAR-related protein 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of LYNX1

  • Previous studies demonstrated that SLURP-1 activates the alpha7 subtype of keratinocyte nicotinic acetylcholine receptors (nAChRs) and facilitates keratinization and programmed cell death, and that the level of SLURP-2 was found to be upregulated several fold in the hyperproliferative skin of patients with psoriasis [1].
  • Borna disease in a free-ranging lynx (Lynx lynx) [2].
  • DESIGN--A locally maintained population-based mortality register and all insulin-treated diabetes mellitus cases notified to the Leicestershire diabetes register (n = 4680) were linked using record linkage software developed in-house (Lynx) [3].
  • Similar material collected from an eastern bobcat (Lynx rufus rufus) carrying an experimentally infected Cytauxzoon felis parasitemia was inoculated into domestic cats [4].
  • Seroprevalence of Bartonella infection in American free-ranging and captive pumas (Felis concolor) and bobcats (Lynx rufus) [5].
 

High impact information on LYNX1

  • Consistent with reports that mutations resulting in hyperactivation of nAChRs can lead to neurodegeneration, aging lynx1 null mutant mice exhibit a vacuolating degeneration that is exacerbated by nicotine and ameliorated by null mutations in nAChRs [6].
  • The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo [6].
  • Nicotinic acetylcholine receptors (nAChRs) affect a wide array of biological processes, including learning and memory, attention, and addiction. lynx1, the founding member of a family of mammalian prototoxins, modulates nAChR function in vitro by altering agonist sensitivity and desensitization kinetics [6].
  • Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1 [7].
  • In cerebellar neurons, lynx1 protein is localized to a specific subdomain including the soma and proximal dendrites. lynx1 binding to brain sections correlates with the distribution of nAChRs, and application of lynx1 to Xenopus oocytes expressing nAChRs results in an increase in acetylcholine-evoked macroscopic currents [8].
 

Biological context of LYNX1

 

Anatomical context of LYNX1

 

Associations of LYNX1 with chemical compounds

  • The aim of the present study was to identify relevant fecal testosterone metabolites in the Eurasian lynx (Lynx lynx) using HPLC analysis and to evaluate the specificity of two testosterone immunoassays against these fecal metabolites [12].
  • Air entrainment samples of volatiles from panicles of intact wheat, Triticum aestivum, cultivar 'Lynx' were collected at the ear emergence/early anthesis growth stage [13].
  • In the period 1985-2003, Trichinella larvae were detected in the muscles of 81/1800 (4.5%) red foxes (Vulpes vulpes), 1/6 (16.7%) arctic fox (Alopex lagopus), 1/7 (14.3%) wolf (Canis lupus), 10/200 (5.0%) lynxes (Lynx lynx), 4/8000 (0.05%) wild boars (Sus scrofa), and 27/66 x 10(6) (0.000041%) domestic pigs [14].
  • Plague as a Mortality Factor in Canada Lynx (Lynx canadensis) Reintroduced to Colorado [15].
 

Analytical, diagnostic and therapeutic context of LYNX1

  • Comparison of the expression of this gene among the psoriatic lesional and nonlesional skin of patients and the normal skin of healthy individuals detected by quantitative real-time RT-PCR analysis disclosed that SLURP-2 was up-regulated threefold in psoriatic lesional skin [9].
  • Embryo transfer and embryonic capsules in the bobcat (Lynx rufus) [16].
  • It was used an electromyography Lynx with 6 channels [17].

References

  1. SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium. Arredondo, J., Chernyavsky, A.I., Jolkovsky, D.L., Webber, R.J., Grando, S.A. J. Cell. Physiol. (2006) [Pubmed]
  2. Borna disease in a free-ranging lynx (Lynx lynx). Degiorgis, M.P., Berg, A.L., Hârd Af Segerstad, C., Mörner, T., Johansson, M., Berg, M. J. Clin. Microbiol. (2000) [Pubmed]
  3. Insulin treated diabetes mellitus: causes of death determined from record linkage of population based registers in Leicestershire, UK. Raymond, N.T., Langley, J.D., Goyder, E., Botha, J.L., Burden, A.C., Hearnshaw, J.R. Journal of epidemiology and community health. (1995) [Pubmed]
  4. Experimental transmission of Cytauxzoon felis from bobcats (Lynx rufus) to domestic cats (Felis domesticus). Kier, A.B., Wagner, J.E., Morehouse, L.G. Am. J. Vet. Res. (1982) [Pubmed]
  5. Seroprevalence of Bartonella infection in American free-ranging and captive pumas (Felis concolor) and bobcats (Lynx rufus). Chomel, B.B., Kikuchi, Y., Martenson, J.S., Roelke-Parker, M.E., Chang, C.C., Kasten, R.W., Foley, J.E., Laudre, J., Murphy, K., Swift, P.K., Kramer, V.L., O'brien, S.J. Vet. Res. (2004) [Pubmed]
  6. The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo. Miwa, J.M., Stevens, T.R., King, S.L., Caldarone, B.J., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R.M., Pavlides, C., Lester, H.A., Picciotto, M.R., Heintz, N. Neuron (2006) [Pubmed]
  7. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Ibañez-Tallon, I., Miwa, J.M., Wang, H.L., Adams, N.C., Crabtree, G.W., Sine, S.M., Heintz, N. Neuron (2002) [Pubmed]
  8. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Miwa, J.M., Ibanez-Tallon, I., Crabtree, G.W., Sánchez, R., Sali, A., Role, L.W., Heintz, N. Neuron (1999) [Pubmed]
  9. SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgaris. Tsuji, H., Okamoto, K., Matsuzaka, Y., Iizuka, H., Tamiya, G., Inoko, H. Genomics (2003) [Pubmed]
  10. Landscape location affects genetic variation of Canada lynx (Lynx canadensis). Schwartz, M.K., Mills, L.S., Ortega, Y., Ruggiero, L.F., Allendorf, F.W. Mol. Ecol. (2003) [Pubmed]
  11. Molecular mapping of Fusarium head blight resistance in the winter wheat population Dream/Lynx. Schmolke, M., Zimmermann, G., Buerstmayr, H., Schweizer, G., Miedaner, T., Korzun, V., Ebmeyer, E., Hartl, L. Theor. Appl. Genet. (2005) [Pubmed]
  12. Monitoring testicular activity of male Eurasian (Lynx lynx) and Iberian (Lynx pardinus) lynx by fecal testosterone metabolite measurement. Jewgenow, K., Naidenko, S.V., Goeritz, F., Vargas, A., Dehnhard, M. Gen. Comp. Endocrinol. (2006) [Pubmed]
  13. Responses of female orange wheat Blossom midge, Sitodiplosis mosellana, to wheat panicle volatiles. Birkett, M.A., Bruce, T.J., Martin, J.L., Smart, L.E., Oakley, J., Wadhams, L.J. J. Chem. Ecol. (2004) [Pubmed]
  14. Trichinella pseudospiralis foci in Sweden. Pozio, E., Christensson, D., Stéen, M., Marucci, G., La Rosa, G., Bröjer, C., Mörner, T., Uhlhorn, H., Agren, E., Hall, M. Vet. Parasitol. (2004) [Pubmed]
  15. Plague as a Mortality Factor in Canada Lynx (Lynx canadensis) Reintroduced to Colorado. Wild, M.A., Shenk, T.M., Spraker, T.R. J. Wildl. Dis. (2006) [Pubmed]
  16. Embryo transfer and embryonic capsules in the bobcat (Lynx rufus). Miller, D.L., Waldhalm, S.J., Leopold, B.D., Estill, C. Anatomia, histologia, embryologia. (2002) [Pubmed]
  17. Electromyographical study of the pectoralis major (sternocostal part) and deltoid muscles (middle fibers) in volleyball sequential actions. Bankoff, A.D., Fonseca Neto, D.R., Zago, L.C., Moraes, A.C. Electromyography and clinical neurophysiology. (2006) [Pubmed]
 
WikiGenes - Universities