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Gene Review

SNCB  -  synuclein, beta

Homo sapiens

Synonyms: Beta-synuclein
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Disease relevance of SNCB


Psychiatry related information on SNCB


High impact information on SNCB


Biological context of SNCB


Anatomical context of SNCB


Associations of SNCB with chemical compounds


Regulatory relationships of SNCB


Other interactions of SNCB


Analytical, diagnostic and therapeutic context of SNCB


  1. beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., Masliah, E. Neuron (2001) [Pubmed]
  2. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Hashimoto, M., Rockenstein, E., Mante, M., Crews, L., Bar-On, P., Gage, F.H., Marr, R., Masliah, E. Gene Ther. (2004) [Pubmed]
  3. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Fung, K.M., Rorke, L.B., Giasson, B., Lee, V.M., Trojanowski, J.Q. Acta Neuropathol. (2003) [Pubmed]
  4. Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. Hashimoto, M., Bar-On, P., Ho, G., Takenouchi, T., Rockenstein, E., Crews, L., Masliah, E. J. Biol. Chem. (2004) [Pubmed]
  5. Beta-synuclein gene alterations in dementia with Lewy bodies. Ohtake, H., Limprasert, P., Fan, Y., Onodera, O., Kakita, A., Takahashi, H., Bonner, L.T., Tsuang, D.W., Murray, I.V., Lee, V.M., Trojanowski, J.Q., Ishikawa, A., Idezuka, J., Murata, M., Toda, T., Bird, T.D., Leverenz, J.B., Tsuji, S., La Spada, A.R. Neurology (2004) [Pubmed]
  6. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Lippa, C.F., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q. Ann. Neurol. (1999) [Pubmed]
  7. Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. Kuwahara, T., Koyama, A., Gengyo-Ando, K., Masuda, M., Kowa, H., Tsunoda, M., Mitani, S., Iwatsubo, T. J. Biol. Chem. (2006) [Pubmed]
  8. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. da Costa, C.A., Masliah, E., Checler, F. J. Biol. Chem. (2003) [Pubmed]
  9. Beta-Synuclein-derived peptides with neuroprotective activity: an alternative treatment of neurodegenerative disorders? Windisch, M., Hutter-Paier, B., Schreiner, E., Wronski, R. J. Mol. Neurosci. (2004) [Pubmed]
  10. Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Park, J.Y., Lansbury, P.T. Biochemistry (2003) [Pubmed]
  11. Identification, localization and characterization of the human gamma-synuclein gene. Lavedan, C., Leroy, E., Dehejia, A., Buchholtz, S., Dutra, A., Nussbaum, R.L., Polymeropoulos, M.H. Hum. Genet. (1998) [Pubmed]
  12. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Spillantini, M.G., Divane, A., Goedert, M. Genomics (1995) [Pubmed]
  13. Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease. Rockenstein, E., Hansen, L.A., Mallory, M., Trojanowski, J.Q., Galasko, D., Masliah, E. Brain Res. (2001) [Pubmed]
  14. Forcing nonamyloidogenic beta-synuclein to fibrillate. Yamin, G., Munishkina, L.A., Karymov, M.A., Lyubchenko, Y.L., Uversky, V.N., Fink, A.L. Biochemistry (2005) [Pubmed]
  15. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Chu, Y., Kordower, J.H. Neurobiol. Dis. (2007) [Pubmed]
  16. Expression of beta-synuclein in normal human astrocytes. Tanji, K., Mori, F., Nakajo, S., Imaizumi, T., Yoshida, H., Hirabayashi, T., Yoshimoto, M., Satoh, K., Takahashi, H., Wakabayashi, K. Neuroreport (2001) [Pubmed]
  17. Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization. Nielsen, M.S., Vorum, H., Lindersson, E., Jensen, P.H. J. Biol. Chem. (2001) [Pubmed]
  18. Beta-synuclein exhibits chaperone activity more efficiently than alpha-synuclein. Lee, D., Paik, S.R., Choi, K.Y. FEBS Lett. (2004) [Pubmed]
  19. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. Snyder, H., Mensah, K., Hsu, C., Hashimoto, M., Surgucheva, I.G., Festoff, B., Surguchov, A., Masliah, E., Matouschek, A., Wolozin, B. J. Biol. Chem. (2005) [Pubmed]
  20. Possible implication of ciliary neurotrophic factor (CNTF) and beta-synuclein in the ammonia effect on cultured rat astroglial cells: A study using DNA and protein microarrays. Bodega, G., Suárez, I., López-Fernández, L.A., Almonacid, L., Zaballos, A., Fernández, B. Neurochem. Int. (2006) [Pubmed]
  21. {beta}-synuclein modulates {alpha}-synuclein neurotoxicity by reducing {alpha}-synuclein protein expression. Fan, Y., Limprasert, P., Murray, I.V., Smith, A.C., Lee, V.M., Trojanowski, J.Q., Sopher, B.L., La Spada, A.R. Hum. Mol. Genet. (2006) [Pubmed]
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