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Gene Review

SS18L1  -  synovial sarcoma translocation gene on...

Homo sapiens

Synonyms: CREST, Calcium-responsive transactivator, KIAA0693, LP2261, SS18-like protein 1, ...
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Disease relevance of SS18L1

  • A novel fusion gene, SS18L1/SSX1, in synovial sarcoma [1].
  • BACKGROUND/AIM: The purpose of the present investigation was to compare manual (Crest Complete) and powered toothbrushing (Braun Oral-B 3D Plaque Remover) for their ability to affect clinical parameters of periodontal diseases [2].
  • This study demonstrated the efficacy of the IntelliClean System from Sonicare and Crest in significantly reducing gingivitis and bleeding relative to baseline after 4 weeks of use according to the manufacturer's instructions [3].
  • After a thorough dental prophylaxis, the subjects were instructed to brush their teeth twice daily with either Prevent, Crest Tartar Control Formula (TCF), or Colgate TCF [4].

High impact information on SS18L1

  • Immunolabeling with Crest autoimmune sera, which recognizes centromere proteins, and with MPM-2 monoclonal antibody, which recognizes mitotic phosphoproteins, indicated that the centromeres of the chromosomes assembled a normal metaphase array in the presence of ICRF-187 and ICRF-159 [5].
  • It was observed that the Experimental dentifrice and Crest dentifrice with Sr-polyacrylate exhibited low salivary fluoride availability relative to the Colgate Winterfresh Gel [6].
  • The purpose of this in vitro study was to determine the gloss changes of three different tooth color restorative materials: Flowable composite (Filtek Flow/3M), packable composite (Filtek P60/3M) and ormocer (Definite/DEGUSSA) after two different bleaching regimens (Vivastyle/VIVADENT) and (Crest Professional Whitestrips/PROCTER and GAMBLE) [7].
  • The present in vitro study using engineered oral mucosa confirms that dentifrices (Aquafresh and Crest) contribute to tissue desquamation [8].
  • Through in silico methods with sequence information contained in the public databases, we did the same for the human SS18 gene and two human SS18 homologous genes, SS18L1 and SS18L2 [9].

Chemical compound and disease context of SS18L1

  • The effects of a stabilized 0.454% stannous fluoride dentifrice, currently marketed as Crest Gum Care, on supragingival plaque, gingivitis, gingival bleeding and oral soft tissue condition were studied in 328 adult male and female subjects who completed a six-month, double blind clinical study [10].
  • The Colgate Total (formerly Colgate Precision) was evaluated along with the New Improved Crest Complete, Reach Advanced Design and Oral-B Advantage toothbrushes to compare six-week and three-month effects on plaque and gingivitis [11].
  • PURPOSE: To evaluate the effects of a novel mouthrinse containing 0.07% high bioavailable cetylpyridinium chloride (Crest Pro-Health Rinse) on the development of gingivitis and plaque versus a placebo control over a period of 6 months [12].

Biological context of SS18L1

  • The human SS18L1 gene, which is also made up of 11 exons with similar intron-exon boundaries, was mapped to chromosome 20 band q13 [9].
  • Eighteen adult subjects with at least one site of early enamel caries with an electrical resistance between 1.0 M omega and 20.00 M omega were randomly assigned to either Enamelon, Crest, or a non-fluoride placebo toothpaste and asked to brush twice daily [13].
  • RESULTS: Post-surgical wound healing was statistically significantly improved at day 7 with the trend continuing to day 14 when Mentadent dentifrice was used as compared to Crest dentifrice [14].
  • A Plaque Glycolysis and Regrowth Method (PGRM) has been used to evaluate the in vivo antimicrobial activity of a new stabilized stannous fluoride dentifrice in comparison to a control dentifrice (Regular Crest, containing NaF) and a second commercial dentifrice containing SnF2 [15].
  • A clinical trial was conducted to evaluate the peroxide degradation and dilution kinetics of Crest Whitestrips Supreme, a whitening strip carrying a low, fixed amount of a 14% hydrogen-peroxide bleaching gel [16].

Anatomical context of SS18L1

  • The dentin specimens were then immersed either in an abrasive dentifrice (Crest) slurry or a non-abrasive (water) solution, and an 8.5 minute treatment carried out [17].
  • Ninety (90) subjects with substantially complete dentition used one of the three toothbrushes: Advanced Design Reach, Crest Complete and Oral-B 40 [18].
  • At baseline, the mean levels of desquamated epithelial cells for the 4 treatments were 0.70+/-0.27, 0.63+/-0.20, 0.69+/-0.30, and 0.62+/-0.31 for the Colgate 360 degrees, Oral-B Indicator, Crest SpinBrush PRO, and Oral-B CrossAction, respectively [19].
  • Impact of Crest Night Effects bleaching gel on dental enamel, dentin and key restorative materials. In vitro studies [20].

Associations of SS18L1 with chemical compounds


Regulatory relationships of SS18L1

  • At the end of the study, total stain evaluations were significantly lower in the Platinum dentifrice group (mean 0.84) compared to both Crest Tartar Control dentifrice (1.08) and the low abrasive dentifrice (1.09) at p<0.05 by ANOVA [26].

Other interactions of SS18L1

  • Clinical examinations at baseline, and on days 3, 7, 14, and 18 (Day White), or 21 (Crest Professional Whitestrips and Nite White) included the following parameters: 1) oral tissues; 2) tooth shade by the Vitapan Classical shade guide; 3) tooth shade by a chromameter with a jig; and, 4) tooth sensitivity and gingival irritation [27].
  • With vertical brushing motion using both tooth shapes tested and at all brushing weights, the Colgate Precision toothbrush had significantly greater interproximal access efficacy (p < 0.01 by ANOVA) than the Crest Complete toothbrush [28].
  • Toothbrush types evaluated were the bi-level trim Advanced Design Reach Soft, the ripple trim Crest Complete Large Soft, the flat trim Colgate Plus Full Head Adult Soft, and the flat trim Oral-B 35 [29].
  • With Crest dentifrice, the ID2 removed significantly less (p < or = 0.05) dentin (232 cpm/g) than the ADA reference manual toothbrush (789 cpm/g) [17].

Analytical, diagnostic and therapeutic context of SS18L1

  • BACKGROUND/AIM: The purpose of the present investigation was to determine the effect of self-performed supragingival plaque removal using either manual (Crest Complete) or power (Braun 3D Plaque Remover) toothbrushing on supra and subgingival plaque composition [30].
  • The dentifrices evaluated were Arm & Hammer Dental Care, Colgate Regular, and Crest Regular [31].
  • A single-blind, cross-over design clinical study was conducted to compare the plaque removal efficacy of the Colgate Precision Full Head soft and the Crest Complete soft toothbrushes [32].
  • OBJECTIVE: This study examined the effects of peroxide tooth bleaching, including Crest Whitestrips hydrogen peroxide gel treatments, on the surface hardness and morphology of common dental restorative treatments [33].
  • Conference report: 'Controversies in critical care'. 30-31 August 1997--Carlton Crest Hotel, Sydney, NSW [34].


  1. A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. Storlazzi, C.T., Mertens, F., Mandahl, N., Gisselsson, D., Isaksson, M., Gustafson, P., Domanski, H.A., Panagopoulos, I. Genes Chromosomes Cancer (2003) [Pubmed]
  2. Efficacy of manual and powered toothbrushes (I). Effect on clinical parameters. Haffajee, A.D., Thompson, M., Torresyap, G., Guerrero, D., Socransky, S.S. Journal of clinical periodontology. (2001) [Pubmed]
  3. Effect of a novel integrated power toothbrush and toothpaste oral hygiene system on gingivitis. Barlow, A.P., Zhou, X., Roberts, J., Colgan, P. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (2004) [Pubmed]
  4. The relative clinical effectiveness of three anticalculus dentifrices. Kohut, B.E., Rubin, H., Baron, H.J. Clinical preventive dentistry. (1989) [Pubmed]
  5. Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane). Gorbsky, G.J. Cancer Res. (1994) [Pubmed]
  6. Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats. Afflitto, J., Schmid, R., Esposito, A., Toddywala, R., Gaffar, A. J. Dent. Res. (1992) [Pubmed]
  7. Effect of two different bleaching regimens on the gloss of tooth colored restorative materials. Yalcin, F., Gürgan, S. Dental materials : official publication of the Academy of Dental Materials. (2005) [Pubmed]
  8. Tissue structure, and IL-1beta, IL-8, and TNF-alpha secretions after contact by engineered human oral mucosa with dentifrices. Mostefaoui, Y., Claveau, I., Ross, G., Rouabhia, M. Journal of clinical periodontology. (2002) [Pubmed]
  9. Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. de Bruijn, D.R., Kater-Baats, E., Eleveld, M., Merkx, G., Geurts Van Kessel, A. Cytogenet. Cell Genet. (2001) [Pubmed]
  10. The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding: a six-month study. Perlich, M.A., Bacca, L.A., Bollmer, B.W., Lanzalaco, A.C., McClanahan, S.F., Sewak, L.K., Beiswanger, B.B., Eichold, W.A., Hull, J.R., Jackson, R.D. The Journal of clinical dentistry. (1995) [Pubmed]
  11. The clinical effects on plaque and gingivitis over three-month's use of four complex-design manual toothbrushes. Sharma, N.C., Galustians, J., McCool, J.J., Rustogi, K.N., Volpe, A.R. The Journal of clinical dentistry. (1994) [Pubmed]
  12. A 6-month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque. Mankodi, S., Bauroth, K., Witt, J.J., Bsoul, S., He, T., Gibb, R., Dunavent, J., Hamilton, A. American journal of dentistry. (2005) [Pubmed]
  13. An in vitro assessment and a pilot clinical study of electrical resistance of demineralized enamel. Wolinsky, L.E., Gnagne-Agnero, N.D., Chamkasem, P., Jason, S., Triol, C.W., Winston, A.E. The Journal of clinical dentistry. (1999) [Pubmed]
  14. Effect of a baking soda-peroxide dentifrice on post-surgical wound healing. Dentino, A.R., Ciancio, S.G., Bessinger, M., Mather, M.A., Cancro, L., Fischman, S. American journal of dentistry. (1995) [Pubmed]
  15. Antimicrobial effects of a stabilized stannous fluoride dentifrice in reducing plaque acid production--a single-brushing PGRM study. Liang, N., White, D.J., Cox, E., Busemeyer, B.A. The Journal of clinical dentistry. (1995) [Pubmed]
  16. In-use comparative kinetics of professional whitening strips: peroxide recovery from strips, teeth, gingiva, and saliva. Gerlach, R.W., Barker, M.L., McMillan, D.A., Sagel, P.A., Walden, G.L. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (2004) [Pubmed]
  17. Hard tissue abrasivity of an automatic interdental plaque remover. Schemehorn, B.R., Zwart, A.C. The Journal of clinical dentistry. (1996) [Pubmed]
  18. Clinical plaque removal efficacy of three toothbrushes. Benson, B.J., Henyon, G., Grossman, E. The Journal of clinical dentistry. (1993) [Pubmed]
  19. Clinical efficacy of Colgate 360 degrees and three commercially available toothbrushes on the removal of desquamated epithelial cells. Williams, M.I., Vazquez, J., Cummins, D. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (2004) [Pubmed]
  20. Impact of Crest Night Effects bleaching gel on dental enamel, dentin and key restorative materials. In vitro studies. White, D.J., Kozak, K.M., Zoladz, J.R., Duschner, H.J., Goetz, H. American journal of dentistry. (2003) [Pubmed]
  21. The choice of controls in toothpaste studies. The effect of a number of commercially available toothpastes compared to water on 4-day plaque regrowth. Binney, A., Addy, M., McKeown, S., Everatt, L. Journal of clinical periodontology. (1996) [Pubmed]
  22. Effect of an anticalculus dentifrice on lesion progression under pH cycling conditions in vitro. Featherstone, J.D., Shariati, M., Brugler, S., Fu, J., White, D.J. Caries Res. (1988) [Pubmed]
  23. Clinical evaluation of anticalculus dentifrices. Kazmierczak, M., Mather, M., Ciancio, S., Fischman, S., Cancro, L. Clinical preventive dentistry. (1990) [Pubmed]
  24. A new approach to strip-based tooth whitening: 14% hydrogen peroxide delivered via controlled low dose. Sagel, P.A., Landrigan, W.F. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (2004) [Pubmed]
  25. Effects of nine weeks' use of a new stabilized stannous fluoride dentifrice on intrinsic plaque virulence expressed as acidogenicity and regrowth: a modified PGRM study. Kasturi, R., White, D.J., Lanzalaco, A.C., Macksood, D., Cox, E.R., Bacca, L., Liang, N., Baker, R. The Journal of clinical dentistry. (1995) [Pubmed]
  26. Clinical study to assess the stain removal efficacy of two tartar control dentifrices and a low abrasive dentifrice. Yankell, S.L., Emling, R.C., Prencipe, M., Rustogi, K., Volpe, A.R. The Journal of clinical dentistry. (1994) [Pubmed]
  27. Comparison of clinical efficacy and safety of three professional at-home tooth whitening systems. Li, Y., Lee, S.S., Cartwright, S.L., Wilson, A.C. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (2003) [Pubmed]
  28. Comparison of the laboratory interproximal access efficacy of the Colgate precision toothbrush and the Crest complete toothbrush. Battista, G.W., Petrone, D.M. The Journal of clinical dentistry. (1993) [Pubmed]
  29. Laboratory evaluations of toothbrush interproximal penetration ratios. Yost, K.G., Miluszewski, K.F., Chen, A.C. The Journal of clinical dentistry. (1994) [Pubmed]
  30. Efficacy of manual and powered toothbrushes (II). Effect on microbiological parameters. Haffajee, A.D., Smith, C., Torresyap, G., Thompson, M., Guerrero, D., Socransky, S.S. Journal of clinical periodontology. (2001) [Pubmed]
  31. Laboratory evaluations of three dentifrices with polishing or brushing. Yankell, S.L., Shi, X., Emling, R.C., Nelson, B.J., Triol, C.W. The Journal of clinical dentistry. (1998) [Pubmed]
  32. Clinical plaque removal performance of two manual toothbrushes. Singh, S.M., Deasy, M.J. The Journal of clinical dentistry. (1993) [Pubmed]
  33. Effects of hydrogen peroxide bleaching strip gels on dental restorative materials in vitro: surface microhardness and surface morphology. Duschner, H., Götz, H., White, D.J., Kozak, K.M., Zoladz, J.R. The Journal of clinical dentistry. (2004) [Pubmed]
  34. Conference report: 'Controversies in critical care'. 30-31 August 1997--Carlton Crest Hotel, Sydney, NSW. Elliott, M. Australian critical care : official journal of the Confederation of Australian Critical Care Nurses. (1997) [Pubmed]
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