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MeSH Review

Kidney Tubules, Distal

 
 
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Disease relevance of Kidney Tubules, Distal

 

High impact information on Kidney Tubules, Distal

  • Nox4 is an NADP(H) oxidase that generates signaling levels of superoxide and is found in greatest abundance in the distal renal tubules [5].
  • Synthetic parathyroid hormone fragments shortened at the amino terminus stimulate glucose-6-phosphate dehydrogenase activity in the distal renal tubule [6].
  • In addition, crystals were selectively retained in distal renal tubules containing cells with hyaluronan and osteopontin at their luminal surface [7].
  • OBJECTIVE: The thiazide-sensitive Na-Cl cotransporter (TSC) is located in the distal renal tubules [8].
  • Recent work suggests that a nicotinamide adenine dinucleotide (NAD+)-dependent 11 beta-OHSD isoform is expressed in distal renal tubule, in contrast with the hepatic isoform which is NAD(+)-phosphate (NADP+)-dependent [9].
  • Studies on frog skin, a model tissue with sodium transport properties resembling those of distal renal tubule, increases an cytosolic calcium caused a closure of apical sodium, channels, opening of basolateral chloride channels, and an overall decrese in sodium absorption [10]
 

Anatomical context of Kidney Tubules, Distal

 

Associations of Kidney Tubules, Distal with chemical compounds

 

Gene context of Kidney Tubules, Distal

 

Analytical, diagnostic and therapeutic context of Kidney Tubules, Distal

 

References

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  8. G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women. Matsuo, A., Katsuya, T., Ishikawa, K., Sugimoto, K., Iwashima, Y., Yamamoto, K., Ohishi, M., Rakugi, H., Ogihara, T. J. Hypertens. (2004) [Pubmed]
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  14. Mechanism of aldosterone-induced increase of K+ conductance in early distal renal tubule cells of the frog. Wang, W.H., Henderson, R.M., Geibel, J., White, S., Giebisch, G. J. Membr. Biol. (1989) [Pubmed]
  15. NMDA receptor antagonists to characterize rat renal organic cation transporter function. Fourie, J., Escobar, M.R., Sitar, D.S. Eur. J. Pharmacol. (2002) [Pubmed]
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  18. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Li, S.A., Watanabe, M., Yamada, H., Nagai, A., Kinuta, M., Takei, K. Cell Struct. Funct. (2004) [Pubmed]
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  20. Thrombospondin-1 mediates distal tubule hypertrophy induced by glycated albumin. Yang, Y.L., Chuang, L.Y., Guh, J.Y., Liu, S.F., Hung, M.Y., Liao, T.N., Huang, Y.L. Biochem. J. (2004) [Pubmed]
  21. Increased levels of calbindin-D in serum and urine from patients treated by extracorporeal shock wave lithotripsy. Hasegawa, S., Kato, K., Takashi, M., Zhu, Y., Obata, K., Kinukawa, T., Miyake, K. J. Urol. (1993) [Pubmed]
  22. Calcitriol upregulates expression and activity of the 1b isoform of the plasma membrane calcium pump in immortalized distal kidney tubular cells. Glendenning, P., Ratajczak, T., Dick, I.M., Prince, R.L. Arch. Biochem. Biophys. (2000) [Pubmed]
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