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Gene Review

Itgav  -  integrin alpha V

Mus musculus

Synonyms: 1110004F14Rik, 2610028E01Rik, CD51, D430040G12Rik, Integrin alpha-V, ...
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Disease relevance of Itgav


High impact information on Itgav


Chemical compound and disease context of Itgav


Biological context of Itgav


Anatomical context of Itgav


Associations of Itgav with chemical compounds


Physical interactions of Itgav


Regulatory relationships of Itgav


Other interactions of Itgav

  • We examined the expression of alpha(v)beta3 integrins (CD51/CD61) on mouse bone marrow-derived DC (BM-DC) and their susceptibility to transduction by Ad vectors [20].
  • One of these is the integrin alpha v subunit which associates with various beta chains including beta 5 [29].
  • Similar to in vitro effects, systemic administration of GM-CSF/IL-4 increased the expression of CD51 on splenic DC and rendered these cells susceptible to Ad transduction [20].
  • Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm binding to or fusion with beta1 integrin null eggs [30].
  • In addition, TNF-alpha-induced metastatic properties including adhesion to fibronectin, mRNA expression of integrin alpha v, production of matrix metalloproteinase-9 and invasion were inhibited by gefitinib without affecting cell proliferation [31].

Analytical, diagnostic and therapeutic context of Itgav


  1. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. McCarty, J.H., Monahan-Earley, R.A., Brown, L.F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H.F., Wolburg, H., Bader, B.L., Dvorak, A.M., Hynes, R.O. Mol. Cell. Biol. (2002) [Pubmed]
  2. alphaV integrin promotes in vitro and in vivo survival of cells in metastatic melanoma. Koistinen, P., Ahonen, M., Kähäri, V.M., Heino, J. Int. J. Cancer (2004) [Pubmed]
  3. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Munger, J.S., Huang, X., Kawakatsu, H., Griffiths, M.J., Dalton, S.L., Wu, J., Pittet, J.F., Kaminski, N., Garat, C., Matthay, M.A., Rifkin, D.B., Sheppard, D. Cell (1999) [Pubmed]
  4. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Reynolds, L.E., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D., Hynes, R.O., Hodivala-Dilke, K.M. Nat. Med. (2002) [Pubmed]
  5. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Bader, B.L., Rayburn, H., Crowley, D., Hynes, R.O. Cell (1998) [Pubmed]
  6. NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Dormond, O., Foletti, A., Paroz, C., Rüegg, C. Nat. Med. (2001) [Pubmed]
  7. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Arap, W., Pasqualini, R., Ruoslahti, E. Science (1998) [Pubmed]
  8. Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes. Weiss, J.M., Renkl, A.C., Maier, C.S., Kimmig, M., Liaw, L., Ahrens, T., Kon, S., Maeda, M., Hotta, H., Uede, T., Simon, J.C. J. Exp. Med. (2001) [Pubmed]
  9. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Brooks, P.C., Klemke, R.L., Schon, S., Lewis, J.M., Schwartz, M.A., Cheresh, D.A. J. Clin. Invest. (1997) [Pubmed]
  10. Effects of the novel alphav integrin antagonist SM256 and cis-platinum on growth of murine squamous cell carcinoma PAM LY8. Van Waes, C., Enamorado-Ayala, I., Hecht, D., Sulica, L., Chen, Z., Batt, D.G., Mousa, S. Int. J. Oncol. (2000) [Pubmed]
  11. CAR- or alphav integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice. Mizuguchi, H., Koizumi, N., Hosono, T., Ishii-Watabe, A., Uchida, E., Utoguchi, N., Watanabe, Y., Hayakawa, T. Gene Ther. (2002) [Pubmed]
  12. Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity. Koizumi, N., Kawabata, K., Sakurai, F., Watanabe, Y., Hayakawa, T., Mizuguchi, H. Hum. Gene Ther. (2006) [Pubmed]
  13. In vivo therapy of malignant melanoma by means of antagonists of alphav integrins. Mitjans, F., Meyer, T., Fittschen, C., Goodman, S., Jonczyk, A., Marshall, J.F., Reyes, G., Piulats, J. Int. J. Cancer (2000) [Pubmed]
  14. Amino acid mutagenesis within ligand-binding loops in alpha v confers loss-of-function or gain-of-function phenotype on integrin alpha v beta 3. Honda, S., Kashiwagi, H., Kiyoi, T., Kato, H., Kosugi, S., Shiraga, M., Kurata, Y., Tomiyama, Y. Thromb. Haemost. (2004) [Pubmed]
  15. Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alphav integrins and the participation of MMP2. Leroy-Dudal, J., Demeilliers, C., Gallet, O., Pauthe, E., Dutoit, S., Agniel, R., Gauduchon, P., Carreiras, F. Int. J. Cancer (2005) [Pubmed]
  16. Both adhesion to immobilized vitronectin and FcepsilonRI cross-linking cause enhanced focal adhesion kinase phosphorylation in murine mast cells. Bhattacharyya, S.P., Mekori, Y.A., Hoh, D., Paolini, R., Metcalfe, D.D., Bianchine, P.J. Immunology (1999) [Pubmed]
  17. Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. Felding-Habermann, B., Mueller, B.M., Romerdahl, C.A., Cheresh, D.A. J. Clin. Invest. (1992) [Pubmed]
  18. Interleukin-4 induces expression of the integrin alpha v beta 3 via transactivation of the beta 3 gene. Kitazawa, S., Ross, F.P., McHugh, K., Teitelbaum, S.L. J. Biol. Chem. (1995) [Pubmed]
  19. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. Huang, X.Z., Wu, J.F., Cass, D., Erle, D.J., Corry, D., Young, S.G., Farese, R.V., Sheppard, D. J. Cell Biol. (1996) [Pubmed]
  20. Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrins. Harui, A., Roth, M.D., Vira, D., Sanghvi, M., Mizuguchi, H., Basak, S.K. J. Leukoc. Biol. (2006) [Pubmed]
  21. Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. Nip, J., Shibata, H., Loskutoff, D.J., Cheresh, D.A., Brodt, P. J. Clin. Invest. (1992) [Pubmed]
  22. Transcriptional activation of endothelial cell integrin alpha v by protein kinase C activator 12(S)-HETE. Tang, D.G., Diglio, C.A., Bazaz, R., Honn, K.V. J. Cell. Sci. (1995) [Pubmed]
  23. Induction of expression of the alpha v beta 1 and alpha v beta 3 integrin heterodimers during retinoic acid-induced neuronal differentiation of murine embryonal carcinoma cells. Dedhar, S., Robertson, K., Gray, V. J. Biol. Chem. (1991) [Pubmed]
  24. Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. Joshi, P., Chung, C.Y., Aukhil, I., Erickson, H.P. J. Cell. Sci. (1993) [Pubmed]
  25. Specific reduction in osteopontin synthesis by antisense RNA inhibits the tumorigenicity of transformed Rat1 fibroblasts. Gardner, H.A., Berse, B., Senger, D.R. Oncogene (1994) [Pubmed]
  26. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Minamiguchi, K., Kumagai, H., Masuda, T., Kawada, M., Ishizuka, M., Takeuchi, T. Int. J. Cancer (2001) [Pubmed]
  27. Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. Tarui, T., Akakura, N., Majumdar, M., Andronicos, N., Takagi, J., Mazar, A.P., Bdeir, K., Kuo, A., Yarovoi, S.V., Cines, D.B., Takada, Y. Thromb. Haemost. (2006) [Pubmed]
  28. Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. Moro, L., Venturino, M., Bozzo, C., Silengo, L., Altruda, F., Beguinot, L., Tarone, G., Defilippi, P. EMBO J. (1998) [Pubmed]
  29. Integrins beta 5, beta 3 and alpha v are apically distributed in endometrial epithelium. Aplin, J.D., Spanswick, C., Behzad, F., Kimber, S.J., Vićovac, L. Mol. Hum. Reprod. (1996) [Pubmed]
  30. None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. He, Z.Y., Brakebusch, C., Fässler, R., Kreidberg, J.A., Primakoff, P., Myles, D.G. Dev. Biol. (2003) [Pubmed]
  31. Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib. Ueno, Y., Sakurai, H., Matsuo, M., Choo, M.K., Koizumi, K., Saiki, I. Br. J. Cancer (2005) [Pubmed]
  32. Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells. Shinohara, T., Orwig, K.E., Avarbock, M.R., Brinster, R.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  33. Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions. Einfeld, D.A., Schroeder, R., Roelvink, P.W., Lizonova, A., King, C.R., Kovesdi, I., Wickham, T.J. J. Virol. (2001) [Pubmed]
  34. Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy. Harris, T.D., Kalogeropoulos, S., Nguyen, T., Liu, S., Bartis, J., Ellars, C., Edwards, S., Onthank, D., Silva, P., Yalamanchili, P., Robinson, S., Lazewatsky, J., Barrett, J., Bozarth, J. Cancer Biother. Radiopharm. (2003) [Pubmed]
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