The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ulex

  • Carcinoma-specific Ulex europaeus agglutinin-I binding glycoproteins of human colorectal carcinoma and its relation to carcinoembryonic antigen [1].
  • Previous immuno- and lectin-histochemical studies using mAbs and Ulex europaeus lectin I, which recognize various fucose-containing blood group antigens, have shown an increased expression of Lewis and H blood group antigens in endometrial carcinoma [2].
  • A Ulex europeus agglutinin I (UEAI)-reactive glycoprotein(s) with molecular weight higher than 300,000 was detected by direct binding of 125I-labeled UEAI to lysates of rectal or sigmoid colon cancer tissues separated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate [3].
  • Seven mouse monoclonal antibodies and the lectin Ulex europaeus, detecting blood group related antigens of the ABH and Lewis systems, have been used to determine the immunophenotype of human renal cell carcinomas [4].
  • In human tumors, Ulex europaeus agglutinin I (UEA I) showed no binding; whereas concanavalin A (Con A), Ricinus communis agglutinin I (RCA I), wheat germ agglutinin (WGA), soybean agglutinin (SBA), and Dolichos biflorus agglutinin (DBA) bound equally to primaries and metastases [5].

High impact information on Ulex

  • Tissue from the proximal and distal colon of each animal was incubated with Triticum vulgaris, Arachis hypogaea, Glycine max, or Ulex europeus agglutinin I [6].
  • We conclude that Ulex europeus agglutinin binding is a consistent feature of premalignant colonic mucosa in dimethylhydrazine-treated rats [7].
  • The specimens were stained with periodic acid-Schiff to detect neutral mucins, high-iron diamine alcian blue to detect sialylated and sulfated mucins, fluoresceinated peanut agglutinin, and fluoresceinated Ulex europeus agglutinin [7].
  • These villi can be rapidly identified in fixed whole-mount preparations of intestine using the alpha-L-fucose-specific Ulex europaeus agglutinin type I (UEA-I) lectin [8].
  • Furthermore, the fucose-specific lectin Ulex europeus agglutinin I bound both to the isolated HMGs and to monomer nucleosomes containing HMGs released from "active chromatin" by micrococcal nuclease digestion [9].

Chemical compound and disease context of Ulex

  • Formalin-fixed and paraffin-embedded specimens of 24 human gliomas were examined histochemically with five lectins; concanavalin A (Con A), wheat germ agglutinin (WGA), Ricinus communis agglutinin 1 (RCA-1), peanut agglutinin (PNA), and Ulex europaeus agglutinin 1 (UEA-1) [10].
  • Localization of binding sites of Ulex europaeus I, Helix pomatia and Griffonia simplicifolia I-B4 lectins and analysis of their backbone structures by several glycosidases and poly-N-acetyllactosamine-specific lectins in human breast carcinomas [11].
  • The architectural expression of an anastomosing vascular pattern in areas of tumor, combined with the positive staining for Factor VIII-related antigen (FVIIIRAg) and Ulex europaeus agglutinin-1 (UEA1) enabled us to make a diagnosis of angiosarcoma [12].
  • Formaldehyde-fixed, paraffin-embedded sections from eight angiosarcomas were studied using the antibodies anti-factor VIII-related antigen (FVIII-RA), Ulex europaeus I agglutinin, anti-CD34 (QBEND/10) and anti-CD31 (JC70) [13].

Biological context of Ulex

  • In 10 cases, immunohistochemical staining for factor VIII-related antigen, CD34, CD31, or Ulex europaeus agglutinin I was performed on the cytology or histology specimen [14].
  • We investigated the expression of the SH2 antigen, along with the endothelial markers factor VIII-related antigen and Ulex europaeus I (UEA-I) lectin during specific developmental periods in human dermal embryogenesis and in the postnatal period through aged adults [15].
  • In surgical pathology the most frequently applied markers are anti-Factor VIII-related antigen (anti-FVIII-R:AG) and Ulex europeus I agglutinin (UEA I) because of their ability to work on routinely formalin-fixed paraffin-embedded tissue [16].
  • The plant lectin Ulex europus agglutinin, Type I (UEA) binds fucosylated oligosaccharides, while UEA-reactive substances have a tissue distribution similar to carcinoembryonic antigen (CEA) [17].
  • Almost all GFP-positive cells were positive for major histocompatibility complex (MHC) class II antigen staining and were positive for both cytokeratin and Ulex Europaeus Agglutinin I, markers of medullary thymic epithelial cells, but were negative for CD11c, Gr-1, and CD45, markers of dendritic cells, macrophages, and B-lymphocytes, respectively [18].

Anatomical context of Ulex


Associations of Ulex with chemical compounds

  • However, Ulex europeus agglutinin, which bound to only 3% of control biopsy specimens throughout the course of the study, bound to increasing numbers of biopsy specimens in the dimethylhydrazine-treated animals, reaching a maximum of 90% positivity by 13-16 wk [7].
  • These TC consistently lacked surface L-fucose residues, as shown by lack of Ulex europaeus agglutinin binding [24].
  • They use seven markers to characterize endothelial cells: three antigens (Factor VIII-related antigen, HLA-DR/Ia, macrophage/endothelial antigens), three enzymes (5'-nucleotidase, ATPase, alkaline phosphatase), and lectin binding (Ulex europaeus I) [25].
  • The inability of the receptor to bind to concanavalin A, Dolichus biflorus agglutinin, Ulex europeaus I, and Jacalin lectin affinity columns suggests that high mannose, N-acetylgalactosamine, fucose, and O-linked carbohydrates are not associated with receptor [26].
  • SMEC were isolated, primarily, by the use of lectin-coated (Ulex europaeus agglutinin type I), magnetizable polystyrene beads [27].

Gene context of Ulex

  • Phenotypic analysis of the cells within the adherent population reveals that the majority display endothelial features, including the expression of KDR, Tie-2, Ulex europaeus agglutinin-1, and von Willebrand factor [28].
  • Immunohistochemically, all cases tested were positive for at least one endothelial marker (CD31, CD34, factor VIII, Ulex europaeus), six of 23 (26%) were positive for cytokeratin, and five of 11 (45%) were positive for alpha-smooth muscle actin [29].
  • Using the M cell specific lectin Ulex europaeus agglutinin 1 (UEA-1), PGRP-S expression was nearly exclusively co-localized with UEA-1+ M cells [30].
  • The AS-M cells manifested endothelial characteristics, such as active uptake of acetylated low-density lipoprotein labeled with 1,1'-dioctadecyl 3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil-Ac-LDL), capacity to bind the Ulex europeaus agglutin-I (UEA-I), and expression of von Willebrand factor (vWF) and CD31 [31].
  • Morphological examinations involved the application of routine histological stains and immunohistochemical reactions with antibodies against human albumin, GFAP, macrophage antigen CD 68 and lectins (Ulex europaeus, Wheat Germ agglutinin and Bandeirea simplicifolia) [32].

Analytical, diagnostic and therapeutic context of Ulex

  • Two hundred and one primary and restenotic coronary atherectomy specimens were analyzed for the presence of microvessels and proliferation as reflected by positive immunolabeling for Ulex agglutinin and the proliferating cell nuclear antigen, respectively [33].
  • The fractions were characterized by light microscopy, by indirect immunofluorescence using specific lectins (Bandeirea simplicifolia and Ulex europaeus) and an antibody against the spinous 67-kDa keratin polypeptides, and by electrophoretic analysis of the keratin polypeptide patterns [34].
  • Positive lectin histochemistry (Ulex Europeus I) and positive immunohistochemistry for factor-VIII-related antigen, actin, and vimentin also gave strong support for the endothelial differentiation of the tumor cells [35].
  • Many lectins display blood group activity, and extracts from Dolichos biflorus (anti-A1), Ulex europaeus (anti-H), and Vicia graminea (anti-N) seeds provide an alternative to human sera as a source of blood-typing reagents [36].
  • Several proteins, present in the 0.4 M NaCl nuclear extract, with M(r) ranging from 35,000 to 115,000 were identified on Western blots as fucosylated glycoproteins owing to their binding to the fucose-specific lectin, Ulex europeus agglutinin I [37].


  1. Carcinoma-specific Ulex europaeus agglutinin-I binding glycoproteins of human colorectal carcinoma and its relation to carcinoembryonic antigen. Matsushita, Y., Yonezawa, S., Nakamura, T., Shimizu, S., Ozawa, M., Muramatsu, T., Sato, E. J. Natl. Cancer Inst. (1985) [Pubmed]
  2. Fucosyltransferase and alpha-L-fucosidase activities and fucose levels in normal and malignant endometrial tissue. Wang, J.W., Ambros, R.A., Weber, P.B., Rosano, T.G. Cancer Res. (1995) [Pubmed]
  3. Ulex europeus agglutinin I-reactive high molecular weight glycoproteins of adenocarcinoma of distal colon and rectum and their possible relationship with metastatic potential. Irimura, T., Ota, D.M., Cleary, K.R. Cancer Res. (1987) [Pubmed]
  4. Blood group-related antigens in human kidney: modulation of Lewis determinants in renal cell carcinoma. Cordon-Cardo, C., Reuter, V.E., Finstad, C.L., Sheinfeld, J., Lloyd, K.O., Fair, W.R., Melamed, M.R. Cancer Res. (1989) [Pubmed]
  5. Differences in lectin binding in tissue sections of human and murine malignant tumors and their metastases. Kahn, H.J., Baumal, R. Am. J. Pathol. (1985) [Pubmed]
  6. Lectin binding patterns in developing rat colon. Colony, P.C., Steely, J. Gastroenterology (1987) [Pubmed]
  7. Serial observations of colonic carcinogenesis in the rat. Premalignant mucosa binds Ulex europeus agglutinin. Shioda, Y., Brown, W.R., Ahnen, D.J. Gastroenterology (1987) [Pubmed]
  8. Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated. Hermiston, M.L., Green, R.P., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Carbohydrate modifications of the high mobility group proteins. Reeves, R., Chang, D., Chung, S.C. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  10. Lectin histochemistry of human gliomas. Wang, X.C., Kochi, N., Tani, E., Kaba, K., Matsumoto, T., Shindo, H. Acta Neuropathol. (1989) [Pubmed]
  11. Localization of binding sites of Ulex europaeus I, Helix pomatia and Griffonia simplicifolia I-B4 lectins and analysis of their backbone structures by several glycosidases and poly-N-acetyllactosamine-specific lectins in human breast carcinomas. Ito, N., Imai, S., Haga, S., Nagaike, C., Morimura, Y., Hatake, K. Histochem. Cell Biol. (1996) [Pubmed]
  12. Cutaneous granular cell angiosarcoma. Hitchcock, M.G., Hurt, M.A., Santa Cruz, D.J. J. Cutan. Pathol. (1994) [Pubmed]
  13. Different immunoreactivity of endothelial markers in well and poorly differentiated areas of angiosarcomas. Poblet, E., Gonzalez-Palacios, F., Jimenez, F.J. Virchows Arch. (1996) [Pubmed]
  14. Cytology of angiosarcoma. Findings in fourteen fine-needle aspiration biopsy specimens and one pleural fluid specimen. Boucher, L.D., Swanson, P.E., Stanley, M.W., Silverman, J.F., Raab, S.S., Geisinger, K.R. Am. J. Clin. Pathol. (2000) [Pubmed]
  15. Monoclonal antibody against adult marrow-derived mesenchymal stem cells recognizes developing vasculature in embryonic human skin. Fleming, J.E., Haynesworth, S.E., Cassiede, P., Baber, M.A., Caplan, A.I. Dev. Dyn. (1998) [Pubmed]
  16. Immunocytochemistry of angiosarcomas. A study of 19 cases with special emphasis on the applicability of endothelial cell specific markers to routinely prepared tissues. Alles, J.U., Bosslet, K. Am. J. Clin. Pathol. (1988) [Pubmed]
  17. Ulex europeus type I agglutinin detects carcinoembryonic antigen in extracts of human colorectal carcinoma. Jessup, J.M., Qi, K.F., Kanellopoulos, K., Cleary, K., Hickey, C., Reading, C.L. J. Cell. Biochem. (1988) [Pubmed]
  18. Antigen-presenting cells expressing glutamate decarboxylase 67 were identified as epithelial cells in glutamate decarboxylase 67-GFP knock-in mouse thymus. Maemura, K., Yanagawa, Y., Obata, K., Dohi, T., Egashira, Y., Shibayama, Y., Watanabe, M. Tissue Antigens (2006) [Pubmed]
  19. Development of human peribiliary capillary plexus: a lectin-histochemical and immunohistochemical study. Terada, T., Nakanuma, Y. Hepatology (1993) [Pubmed]
  20. Culture and properties of cells derived from Kaposi sarcoma. Corbeil, J., Evans, L.A., Vasak, E., Cooper, D.A., Penny, R. J. Immunol. (1991) [Pubmed]
  21. Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Kure, K., Lyman, W.D., Weidenheim, K.M., Dickson, D.W. Am. J. Pathol. (1990) [Pubmed]
  22. A cytochemical study of lectin receptors on isolated chick neural retina neurons in vitro. Bee, J.A. J. Cell. Sci. (1982) [Pubmed]
  23. The binding of peroxidase-labelled lectins to human breast epithelium. I--Normal, hyperplastic and lactating breast. Walker, R.A. J. Pathol. (1984) [Pubmed]
  24. Human leukemia-derived cell lines and clones as models for mechanistic analysis of natural killer cell-mediated cytotoxicity. Zarcone, D., Tilden, A.B., Friedman, H.M., Grossi, C.E. Cancer Res. (1987) [Pubmed]
  25. Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium. Beckstead, J.H., Wood, G.S., Fletcher, V. Am. J. Pathol. (1985) [Pubmed]
  26. Structural analysis and functional role of the carbohydrate component of somatostatin receptors. Rens-Domiano, S., Reisine, T. J. Biol. Chem. (1991) [Pubmed]
  27. Isolation and culture of synovial microvascular endothelial cells. Characterization and assessment of adhesion molecule expression. Abbot, S.E., Kaul, A., Stevens, C.R., Blake, D.R. Arthritis Rheum. (1992) [Pubmed]
  28. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Gehling, U.M., Ergün, S., Schumacher, U., Wagener, C., Pantel, K., Otte, M., Schuch, G., Schafhausen, P., Mende, T., Kilic, N., Kluge, K., Schäfer, B., Hossfeld, D.K., Fiedler, W. Blood (2000) [Pubmed]
  29. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Mentzel, T., Beham, A., Calonje, E., Katenkamp, D., Fletcher, C.D. Am. J. Surg. Pathol. (1997) [Pubmed]
  30. Peptidoglycan recognition protein expression in mouse Peyer's Patch follicle associated epithelium suggests functional specialization. Lo, D., Tynan, W., Dickerson, J., Mendy, J., Chang, H.W., Scharf, M., Byrne, D., Brayden, D., Higgins, L., Evans, C., O'Mahony, D.J. Cell. Immunol. (2003) [Pubmed]
  31. Establishment and characterization of an angiosarcoma-derived cell line, AS-M. Krump-Konvalinkova, V., Bittinger, F., Olert, J., Bräuninger, W., Brunner, J., Kirkpatrick, C.J. Endothelium (2003) [Pubmed]
  32. Remote morphological changes in the white matter after ischaemic stroke. Dziewulska, D., Rafałowska, J., Podlecka, A., Szumanska, G. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (2004) [Pubmed]
  33. Angiogenesis in human coronary atherosclerotic plaques. O'Brien, E.R., Garvin, M.R., Dev, R., Stewart, D.K., Hinohara, T., Simpson, J.B., Schwartz, S.M. Am. J. Pathol. (1994) [Pubmed]
  34. Isolation, characterization, and in vitro cultivation of keratinocyte subfractions from adult NMRI mouse epidermis: epidermal target cells for phorbol esters. Gross, M., Fürstenberger, G., Marks, F. Exp. Cell Res. (1987) [Pubmed]
  35. Atypical hemangioendothelioma of venous origin. A clinicopathologic, angiographic, immunohistochemical, and ultrastructural study of two endothelial tumors within the concept of histiocytoid hemangioma. Angervall, L., Kindblom, L.G., Karlsson, K., Stener, B. Am. J. Surg. Pathol. (1985) [Pubmed]
  36. The role of lectins in blood group serology. Judd, W.J. Critical reviews in clinical laboratory sciences. (1980) [Pubmed]
  37. Evidence for the presence of complex high-molecular mass N-linked oligosaccharides in intranuclear glycoproteins from HeLa cells. Codogno, P., Bauvy, C., Sève, A.P., Hubert, M., Ogier-Denis, E., Aubery, M., Hubert, J. J. Cell. Biochem. (1992) [Pubmed]
WikiGenes - Universities