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Gene Review

PAPSS2  -  3'-phosphoadenosine 5'-phosphosulfate...

Homo sapiens

Synonyms: ATPSK2, BCYM4, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, PAPS synthase 2, PAPSS 2, ...
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Disease relevance of PAPSS2


Psychiatry related information on PAPSS2


High impact information on PAPSS2

  • A. borkumensis SK2 has a streamlined genome with a paucity of mobile genetic elements and energy generation-related genes, but with a plethora of genes accounting for its wide hydrocarbon substrate range and efficient oil-degradation capabilities [6].
  • This activation is direct and appears to extend to other xenobiotic sulfotransferases as well as to 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2), an enzyme that generates the donor cofactor for the reaction [7].
  • We found that PAPSS2, which localizes to the cytoplasm when ectopically expressed in mammalian cells, is relocated to the nucleus when coexpressed with PAPSS1 [8].
  • We have determined the order of human BAC clones at the hPTEN locus and that the locus contains hPAPSS2 and hMINPP1 genes oriented as are their Fugu orthologs [9].
  • Furthermore, differential expression was detected for FLJ11218 and PAPSS2 [10].

Biological context of PAPSS2


Anatomical context of PAPSS2

  • After optimal PAPSS assay conditions had been established, substrate kinetic studies were performed with cytosol preparations from human liver and cerebral cortex, two tissues with very different expression patterns for PAPSS1 and PAPSS2 mRNA [13].
  • In brain and skin PAPSS1 is the major expressed isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression predominates and in various other tissues the proportions of the isoform expressions is purported to vary [2].
  • Using a highly selective and sensitive LC-MS/MS approach, here we show that SK1 overexpression, but not SK2, in different primary cells and cultured cell lines results in predominant upregulation of the synthesis of dihydrosphingosine-1-phosphate (DHS1P) compared to S1P [14].
  • Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb) [15].

Associations of PAPSS2 with chemical compounds


Other interactions of PAPSS2


Analytical, diagnostic and therapeutic context of PAPSS2


  1. Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis. Ford-Hutchinson, A.F., Ali, Z., Seerattan, R.A., Cooper, D.M., Hallgrímsson, B., Salo, P.T., Jirik, F.R. Osteoarthr. Cartil. (2005) [Pubmed]
  2. Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency. Venkatachalam, K.V. IUBMB Life (2003) [Pubmed]
  3. Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis. Ikeda, T., Mabuchi, A., Fukuda, A., Hiraoka, H., Kawakami, A., Yamamoto, S., Machida, H., Takatori, Y., Kawaguchi, H., Nakamura, K., Ikegawa, S. J. Hum. Genet. (2001) [Pubmed]
  4. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes. Xu, Z.H., Freimuth, R.R., Eckloff, B., Wieben, E., Weinshilboum, R.M. Pharmacogenetics (2002) [Pubmed]
  5. Exclusion of the dymeclin and PAPSS2 genes in a novel form of spondyloepimetaphyseal dysplasia and mental retardation. Geneviève, D., Héron, D., El Ghouzzi, V., Prost-Squarcioni, C., Le Merrer, M., Jacquette, A., Sanlaville, D., Pinton, F., Villeneuve, N., Kalifa, G., Munnich, A., Cormier-Daire, V. Eur. J. Hum. Genet. (2005) [Pubmed]
  6. Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis. Schneiker, S., Martins dos Santos, V.A., Bartels, D., Bekel, T., Brecht, M., Buhrmester, J., Chernikova, T.N., Denaro, R., Ferrer, M., Gertler, C., Goesmann, A., Golyshina, O.V., Kaminski, F., Khachane, A.N., Lang, S., Linke, B., McHardy, A.C., Meyer, F., Nechitaylo, T., Pühler, A., Regenhardt, D., Rupp, O., Sabirova, J.S., Selbitschka, W., Yakimov, M.M., Timmis, K.N., Vorhölter, F.J., Weidner, S., Kaiser, O., Golyshin, P.N. Nat. Biotechnol. (2006) [Pubmed]
  7. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Sonoda, J., Xie, W., Rosenfeld, J.M., Barwick, J.L., Guzelian, P.S., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. Besset, S., Vincourt, J.B., Amalric, F., Girard, J.P. FASEB J. (2000) [Pubmed]
  9. Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function. Yu, W.P., Pallen, C.J., Tay, A., Jirik, F.R., Brenner, S., Tan, Y.H., Venkatesh, B. Oncogene (2001) [Pubmed]
  10. Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines. Hermans, K.G., van Alewijk, D.C., Veltman, J.A., van Weerden, W., van Kessel, A.G., Trapman, J. Genes Chromosomes Cancer (2004) [Pubmed]
  11. Molecular cloning of a novel human PAPS synthetase which is differentially expressed in metastatic and non-metastatic colon carcinoma cells. Franzon, V.L., Gibson, M.A., Hatzinikolas, G., Woollatt, E., Sutherland, G.R., Cleary, E.G. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  12. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. Xu, Z.H., Otterness, D.M., Freimuth, R.R., Carlini, E.J., Wood, T.C., Mitchell, S., Moon, E., Kim, U.J., Xu, J.P., Siciliano, M.J., Weinshilboum, R.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase: radiochemical enzymatic assay, biochemical properties, and hepatic variation. Xu, Z., Wood, T.C., Adjei, A.A., Weinshilboum, R.M. Drug Metab. Dispos. (2001) [Pubmed]
  14. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Berdyshev, E.V., Gorshkova, I.A., Usatyuk, P., Zhao, Y., Saatian, B., Hubbard, W., Natarajan, V. Cell. Signal. (2006) [Pubmed]
  15. Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L)lysine-alginate membrane. Okada, N., Miyamoto, H., Yoshioka, T., Katsume, A., Saito, H., Yorozu, K., Ueda, O., Itoh, N., Mizuguchi, H., Nakagawa, S., Ohsugi, Y., Mayumi, T. Biochim. Biophys. Acta (1997) [Pubmed]
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