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Gene Review

SESTD1  -  SEC14 and spectrin domains 1

Homo sapiens

Synonyms: DKFZp434O0515, Huntingtin-interacting protein-like protein, Protein Solo, SEC14 domain and spectrin repeat-containing protein 1, SOLO, ...
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Disease relevance of SESTD1

  • OBJECTIVES: We examined the feasibility and efficacy of using a single-pass, dual-electrode (Solo) lead for atrial fibrillation (AF) detection and defibrillation [1].
  • In both myoblasts and neuroblastoma cells, the Solo protein is concentrated around the nucleus [2].
  • We reviewed peritonitis (P) experience of four UK units using single use Y (Freeline T.M., Baxter UK)(F) and Twinbag (Solo T.M., Baxter UK) (S) disconnect systems, which incorporate the 'Flush Before Fill' principle [3].
  • PARTICIPANTS: Patients with external otitis treated by otolaryngologists in Project Solo, a nonprofit, grassroots organization of independent physicians united for quality, patient advocacy, and cost containment [4].

Psychiatry related information on SESTD1

  • Project Solo: an independent practitioner initiative for confidential self-assessment of quality [5].

High impact information on SESTD1

  • Moreover, primary cultured neurons transfected with Solo/Trio8 showed increased neurite elongation that was dependent on these domains [6].
  • Omeprazole 10 mg or 20 mg once daily in the prevention of recurrence of reflux oesophagitis. Solo Investigator Group [7].
  • Acid-etched human dentin treated with 2 oxalate desensitizers (BisBlock and Super Seal) was bonded with 4 simplified total-etch adhesives: One-Step (OS), Single Bond (SB), OptiBond Solo Plus (OB), and Prime&Bond NT (PB) [8].
  • The Solo mRNA is ubiquitously expressed but enriched in brain, its expression peaks perinatally and it undergoes extensive alternative splicing [2].
  • These domains of Solo shared significant amino acid sequence identities with those of mammalian Trio and Karilin [9].

Biological context of SESTD1

  • Genetic diversity among cultivars derived from the same or similar gene pools was smaller, such as Hawaiian Solo hermaphrodite cultivars and Australian dioecious cultivars with genetic similarity at 0.921 and 0.912, respectively [10].
  • Slight but significant increase in the number of chromatid breaks was observed after 24-h elution period, for adhesives Adper(TR) Single Bond 2, Excite((R)), and OptiBond((R)) Solo Plus(TR) at dilutions of 1:10(6) and 1:10(5), and for other two only at dilution of 1:10(5) [11].
  • Contributions of regimen steps and rinse volumes to disinfection abilities of OPTI-FREE EXPRESS, Solo-care Plus (Ciba Vision), Complete (Allergan), and ReNu MultiPlus (Bausch & Lomb) multi-purpose solutions were examined [12].
  • PURPOSE: As adhesives containing hydrophilic/acidic resin components are vulnerable to water movement after polymerization, this study tested the hypothesis that coupling of a single-bottle adhesive (OptiBond Solo Plus) to self/dual-cured composites is compromised by adhesive permeability, even with the adjunctive use of chemical co-initiators [13].

Anatomical context of SESTD1

  • Ninety-six extracted non-carious human molars were randomly assigned to eight groups (n=12) and restored with different adhesive systems: Optibond Solo Plus, iBond, Adper Prompt L-Pop, Xeno III, Simplicity, Nano-Bond, Adper Scotchbond Multi-Purpose and Touch & Bond [14].
  • In the in-depth dye penetration investigation the mean dye penetration ranged from 0.2 +/- 0.2 mm (Point 4/Revolution/Optibond Solo Plus) to 1.7 +/- 0.2 mm (Pertac II/Prompt L-Pop) at the cementum margins [15].
  • METHODS: Restorations were prepared on the dentin surface of 80 bovine incisors using four adhesive systems: two fluoride-free (Single Bond and Clearfil SE Bond) and two fluoride containing (Optibond Solo Plus and Clearfil Protect Bond) [16].
  • Eighty extracted human premolar and molar teeth were randomly assigned to four groups for bonding: the 5th generation bonding system (Optibond Solo), the 6th generation bonding system (Prompt-L-Pop) and the 7th generation bonding system (iBond), and a control group that was used with no dentinal bonding system [17].
  • In this report, human periodontal ligament (PDL) cells were exposed for 1 h to culture medium, milk, Hanks Balanced Salt Solution (HBSS), Soft Wear, Opti Free, and Solo Care contact lens solutions, Gatorade, and tap water, at room temperature and on ice [18].

Associations of SESTD1 with chemical compounds

  • With the use of the products Ariston Liner, Etch & Prime 3.0, Optibond Solo, Prime & Bond NT, Scotchbond 1, and Syntac Sprint, test specimens were prepared according to the manufacturers' instructions and transferred into a culture medium [19].
  • The microtensile bond strength of the conventional adhesive Optibond Solo Plus was significantly greater than that of the self-etching adhesives Tyrian SPE and Prompt L-Pop [20].
  • METHODS: The following adhesives were used: Prime and Bond 2.1 (Dentsply); Single Bond (3M); PrimaBond 97' (BJM); Syntac Sprint (Vivadent); Optibond Solo (Kerr) and Syntac Single Component (Vivadent) [21].
  • Two adhesives and flowable resins were used: Tetric Ceram, Tetric Flow, Excite (Vivadent, Schaan, Liechtenstein) vs. Prodigy Condensable, Revolution, Optibond Solo (Kerr Co., Orange, CA, USA) [22].
  • Fluoride-releasing resins (OptiBond Solo/Protect Bond) did not show reduced biofilm formation [23].

Analytical, diagnostic and therapeutic context of SESTD1

  • With DNA microarrays, we identified a gene, termed Solo, that is downregulated in the cerebellum of Purkinje cell degeneration mutant mice [6].
  • METHODS: We studied the use of the Solo lead for AF detection and defibrillation in 17 patients who underwent cardioversion of chronic AF [1].
  • Before adding the composite Herculite, either Optibond Solo (Kerr), Solobond M (Voco) bonding agent or no bonding agent (control group) was applied [24].
  • MATERIALS AND METHODS: The resin-dentin interface produced by the three-step OptiBond Dual-Cure (Kerr) and its simplified two-step successor OptiBond Solo (Kerr) was ultramorphologically examined using transmission electron microscopy (TEM) and AFM [25].
  • This paper presents a comparison of three children's electric wheelchairs, the Bec, Solo, and Everest and Jennings [26].


  1. Implantable atrial defibrillator with a single-pass dual-electrode lead. Tse, H.F., Lau, C.P., Yomtov, B.M., Ayers, G.M. J. Am. Coll. Cardiol. (1999) [Pubmed]
  2. Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain. Tse, S.W., Broderick, J.A., Wei, M.L., Luo, M.H., Smith, D., McCaffery, P., Stamm, S., Andreadis, A. Gene (2005) [Pubmed]
  3. CAPD disconnect systems: UK peritonitis experience. Lewis, J., Abbott, J., Crompton, K., Fowler, I., Smith, B. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. (1992) [Pubmed]
  4. Problems and pitfalls in community-based outcomes research. Isenberg, S.F., Rosenfeld, R.M. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1997) [Pubmed]
  5. Project Solo: an independent practitioner initiative for confidential self-assessment of quality. Isenberg, S.F., Davis, C., Keaton, S. American journal of medical quality : the official journal of the American College of Medical Quality. (1996) [Pubmed]
  6. Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation. Sun, Y.J., Nishikawa, K., Yuda, H., Wang, Y.L., Osaka, H., Fukazawa, N., Naito, A., Kudo, Y., Wada, K., Aoki, S. Mol. Cell. Biol. (2006) [Pubmed]
  7. Omeprazole 10 mg or 20 mg once daily in the prevention of recurrence of reflux oesophagitis. Solo Investigator Group. Bate, C.M., Booth, S.N., Crowe, J.P., Mountford, R.A., Keeling, P.W., Hepworth-Jones, B., Taylor, M.D., Richardson, P.D. Gut (1995) [Pubmed]
  8. Incompatibility of Oxalate Desensitizers with Acidic, Fluoride-containing Total-etch Adhesives. Yiu, C.K., King, N.M., Suh, B.I., Sharp, L.J., Carvalho, R.M., Pashley, D.H., Tay, F.R. J. Dent. Res. (2005) [Pubmed]
  9. Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. Sato, T., Mishina, M. Genomics (2003) [Pubmed]
  10. Genetic diversity of Carica papaya as revealed by AFLP markers. Kim, M.S., Moore, P.H., Zee, F., Fitch, M.M., Steiger, D.L., Manshardt, R.M., Paull, R.E., Drew, R.A., Sekioka, T., Ming, R. Genome (2002) [Pubmed]
  11. Genotoxicity evaluation of five different dentin bonding agents by chromosomal aberration analysis. Prica, D., Galić, N., Zeljezić, D., Prica, A. Journal of oral rehabilitation. (2006) [Pubmed]
  12. Contribution of regimen steps to disinfection of hydrophilic contact lenses. Rosenthal, R.A., Henry, C.L., Schlech, B.A. Contact lens & anterior eye : the journal of the British Contact Lens Association. (2004) [Pubmed]
  13. Factors contributing to the incompatibility between simplified-step adhesives and self-cured or dual-cured composites. Part II. Single-bottle, total-etch adhesive. Tay, F.R., Suh, B.I., Pashley, D.H., Prati, C., Chuang, S.F., Li, F. The journal of adhesive dentistry. (2003) [Pubmed]
  14. Marginal permeability of self-etch and total-etch adhesive systems. Owens, B.M., Johnson, W.W., Harris, E.F. Operative dentistry. (2006) [Pubmed]
  15. Marginal integrity of different resin-based composites for posterior teeth: an in vitro dye-penetration study on eight resin-composite and compomer-/adhesive combinations with a particular look at the additional use of flow-composites. Ernst, C.P., Cortain, G., Spohn, M., Rippin, G., Willershausen, B. Dental materials : official publication of the Academy of Dental Materials. (2002) [Pubmed]
  16. Adhesive systems and secondary caries formation: Assessment of dentin bond strength, caries lesions depth and fluoride release. Peris, A.R., Mitsui, F.H., Lobo, M.M., Bedran-Russo, A.K., Marchi, G.M. Dental materials : official publication of the Academy of Dental Materials (2007) [Pubmed]
  17. An in vitro evaluation of microleakage in class I preparations using 5th, 6th and 7th generation composite bonding agents. Kallenos, T.N., Al-Badawi, E., White, G.E. The Journal of clinical pediatric dentistry. (2005) [Pubmed]
  18. Survival of human periodontal ligament cells in media proposed for transport of avulsed teeth. Sigalas, E., Regan, J.D., Kramer, P.R., Witherspoon, D.E., Opperman, L.A. Dental traumatology : official publication of International Association for Dental Traumatology. (2004) [Pubmed]
  19. Cytotoxicity of modern dentin adhesives--in vitro testing on gingival fibroblasts. Szep, S., Kunkel, A., Ronge, K., Heidemann, D. J. Biomed. Mater. Res. (2002) [Pubmed]
  20. Microtensile bond strengths of one-step and self-etching adhesive systems. Kerby, R.E., Knobloch, L.A., Clelland, N., Lilley, H., Seghi, R. Operative dentistry. (2005) [Pubmed]
  21. Evaporation of solvent in one-bottle adhesives. Abate, P.F., Rodriguez, V.I., Macchi, R.L. Journal of dentistry. (2000) [Pubmed]
  22. Marginal and internal adaptation of extended class I restorations lined with flowable composites. Haak, R., Wicht, M.J., Noack, M.J. Journal of dentistry. (2003) [Pubmed]
  23. In vitro biofilm formation on the surface of resin-based dentine adhesives. Rolland, S.L., McCabe, J.F., Robinson, C., Walls, A.W. Eur. J. Oral Sci. (2006) [Pubmed]
  24. The effect of air abrasion with two new bonding agents on composite repair. Oztas, N., Alaçam, A., Bardakçy, Y. Operative dentistry. (2003) [Pubmed]
  25. Hybridization effectiveness of a two-step versus a three-step smear layer removing adhesive system examined correlatively by TEM and AFM. Van Meerbeek, B., Yoshida, Y., Snauwaert, J., Hellemans, L., Lambrechts, P., Vanherle, G., Wakasa, K., Pashley, D.H. The journal of adhesive dentistry. (1999) [Pubmed]
  26. A comparison of children's electric wheelchairs. Hines, J., Law, M., Usher, P. Canadian journal of occupational therapy. Revue canadienne d'ergothérapie. (1980) [Pubmed]
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