Disease relevance of KNTC1

• The finding in Rod Bay libraries of high percentage of DNA clones apparently affiliated with beta-Proteobacteria typical for activated sludges and well water could be explained by the presence of a sewage depuration system at this site [1].
• BACKGROUND: Rod-cone retinal degenerations (retinitis pigmentosa) are typified by initial rod loss followed by secondary cone death [2].
• Influence of vestibular and cerebellar dysfunction on the performance of alcoholics on the Rod-and-Frame Test [3].
• The anaesthetic management of patients requiring surgical correction of idiopathic scoliosis using the Harrington Rod Instrumentation Technique is discussed [4].
• The development of the U-shaped Unit Rod for posterior spinal arthrodesis is a recent advance in the treatment of spinal deformity in patients with cerebral palsy [5].

Psychiatry related information on KNTC1

• Linking impulse response functions to reaction time: Rod and cone reaction time data and a computational model [6].
• 38 right-handed children in sixth grade (17 boys and 21 girls) were administered the WISC Block Design to reflect activity of the right hemisphere of the brain and two versions (verbal and nonverbal) of the Rod-and-frame Test, a measure of field dependence/independence [7].
• All subjects underwent a battery of psychological tests which included a test of psychological differentiation (the Rod-and-Frame Test), a test of psychological defenses (Meta-contrast Technique), and the Eysenck Personality Inventory [8].
• 39 visually and nonvisually perceptually impaired 8- to 11-yr.-old boys with learning disabilities were compared with a control group of 35 "normal" learners on the Rod-and-frame and Children's Embedded-figures Tests [9].
• Since there are relationships among awareness of the body, spatial orientation, and physical activity of athletes, the Portable Rod and Frame Test seems to be more applicable to the task of distinguishing between and among athletes and nonathletes [10].

High impact information on KNTC1

• Using immunodepletion from and antibody addition to Xenopus egg extracts, we show that the kinetochore-associated kinesin-like motor protein CENP-E is essential for positioning chromosomes at the metaphase plate [11].
• A major question has been whether kinetochore-associated microtubule motors play an important role in congression [11].
• These data demonstrate a role for kinetochore-associated mBub1 in regulating exit from mitosis, and suggest functional links between the mitotic checkpoint and subsequent apoptotic events in G1 [12].
• As Zw10 and Rod are not conserved in yeast, our data, combined with an accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an elaborate spindle checkpoint to monitor complex kinetochore functions [13].
• ZW10 and Rod play an essential role in this checkpoint [14].

Chemical compound and disease context of KNTC1

• 72 college students completed the Witkin Rod and Frame Test and the Group Embedded Figures Test as measures of Field Dependence/Independence, the Nowicki-Strickland Internal-External Locus of Control Scale, and the Synder Self-monitoring Scale [15].

Biological context of KNTC1

• Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging chromosomes [13].
• Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins [16].
• It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset [17].
• Using a rephosphorylation assay in Xenopus laevis extracts, we identified the kinetochore-associated Polo-like kinase Plx1 as the kinase both necessary and sufficient for this phosphorylation [18].
• We purified kinetochore-associated chromatin from human chromosomes by immunoprecipitation of CENP-A, a centromere-specific histone H3 homologue located in the inner plate of the kinetochore [6,9,10] [19].

Anatomical context of KNTC1

• Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors [13].
• RESULTS: Rod-shaped bacteria were frequently associated with the mucosa of CD patients, with both active and inactive disease, but not with controls [20].

Associations of KNTC1 with chemical compounds

• Improvement in Rod and Cone Function in Mouse Model of Fundus albipunctatus after Pharmacologic Treatment with 9-cis-Retinal [21].
• 3. Rod and cone inputs to OFF-BPs were blocked by kynurenic acid (Kyn), but the doses required were significantly higher for rod inputs: the IC50 (the concentration at which an antagonist blocks 50% of the responses) for Kyn was 0.3 mM for cone inputs and 1 mM for rod inputs [22].
• The results, obtained by means of a mini Short Rod Fracture Toughness Test specimen design, suggest that while water aging does not produce significant changes in KIC, aging in ethanol does cause significant increases in fracture toughness for three of the four dental composites studied [23].
• Application of Fluorescence Correlation Spectroscopy: A Study of Flocculation of Rigid Rod-like Biopolymer (Schizophyllan) and Colloidal Particles [24].
• General Shape Control of Colloidal CdS, CdSe, CdTe Quantum Rods and Quantum Rod Heterostructures [25].

Other interactions of KNTC1

• The gene that encodes CENPE, a kinetochore-associated motor protein that is postulated to segregate chromosomes during mitosis, maps to chromosome 4q24-->q25 [26].
• This novel localization of Plk1 suggests that substrates and/or regulators of Plks may be found among kinetochore-associated proteins with important functions in chromosome segregation and/or spindle checkpoint mechanisms [27].
• Our data demonstrate that NEK2A is a kinetochore-associated protein kinase essential for faithful chromosome segregation [28].
• Microinjection of excess importin-beta or depletion of the Ran-dependent spindle assembly factor, TPX2, blocked kinetochore-associated microtubule formation, enhanced centrosome-associated microtubule formation, but did not prevent chromosome capture by centrosomal microtubules [29].
• The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A [30].

Analytical, diagnostic and therapeutic context of KNTC1

• By immunocytochemistry we show that Rod displays a dynamic intracellular staining pattern, localizing first to kinetochores in prometaphase, but moving to kinetochore microtubules at metaphase [31].
• METHODS: Rod sources with 201Tl, 153Gd, and 99mTc were used on a triple-head gamma camera [32].
• Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure [33].
• This was a retrospective review of one surgeon's results using three different lumbosacral arthrodesis techniques: Group 1, no instrumentation; Group 2, Luque Rod and sublaminar wire technique; and Group 3, AO intrapedicular screw and plate technique [34].
• When a mean unsigned error was used as score for the Rod and Frame Test, more field-independent subjects consistently showed lower EEG coherence spectra than more field-dependent subjects [35].

References