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Gene Review

ZBED1  -  zinc finger, BED-type containing 1

Homo sapiens

Synonyms: ALTE, DREF, KIAA0785, TRAMP, Zinc finger BED domain-containing protein 1, ...
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Disease relevance of ZBED1

  • Among infants in the ALTE group, events during the initial investigation period predicted the likelihood of events at home; 2 of the 47 infants (4%) with negative results for an investigation and no events recorded in hospital had apnea, and 4 had a bradycardic event (9%) [1].
  • The infants were allocated to one of four diagnostic categories: apparent life-threatening events (ALTE, n = 73), former premature infants with persistent apnea and bradycardia (n = 29), siblings of victims of sudden infant death syndrome (SIDS) (n = 24), and parental anxiety after a nonsignificant event (n = 21) [1].
  • CONCLUSIONS: Pyrimidine degradation defects should be included in the differential diagnosis of convulsions, (febrile) status epilepticus, psychomotor retardation and possibly also ALTE-like events [2].
  • Differences between radiologists for the minimum diameter (Dmin), the reference diameter (Dref), and the percentage of stenosis of the renal arteries were analyzed [3].
  • Respiratory and arousal responses to mild hypoxia (15% oxygen in nitrogen) were recorded in 18 healthy infants and 33 infants who had sustained severe sleep related apnoeic events (ALTE) [4].

High impact information on ZBED1

  • In the human genome, the Tramp protein may be involved in the transposition of other transposable elements, like medium reiterated frequency repeats, or it could be specialized in the acquisition of a new cellular function [5].
  • We report the cloning of a novel gene, called Tramp, in the Xp/Yp PAR region that has a functional homologue on the Y chromosome and escapes X-inactivation [5].
  • These results suggest that expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation [6].
  • Analyses using a specific antibody revealed that an hDREF/KIAA0785 binds to the promoter region of the histone H1 gene [6].
  • A human homologue (hDREF/KIAA0785) of Drosophila DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation, was identified by BLAST search [6].

Chemical compound and disease context of ZBED1

  • 6SMT was assessed in the following groups of infants: 15 infants with ALTE for whom home monitoring had been recommended, 15 infants who had had an abrupt cyanotic apneic event but did not require mouth-to-mouth resuscitation, 15 siblings of those who had died from sudden infant death syndrome (SIDS), and 35 age-matched healthy comparison infants [7].

Biological context of ZBED1


Anatomical context of ZBED1


Associations of ZBED1 with chemical compounds

  • The diurnal 6SMT rhythms in the ALTE infants were characterized by lower 24-hour mean and amplitude values, whereas the time of peak and nadir excretion rates (07:15 to 08:45 hours and 14:45 to 16:15 hours respectively) was similar in all four infant groups [7].
  • Rhythmic succinate dehydrogenase activity in the slug, Laevicaulis alte (Ferussac, 1821) [13].
  • The preferred food items of the slugs Laevicaulis alte and the snails Achatina fulica were used to prepare 'poison baits' by injecting the pesticides 'Rogor' and 'Nuvan' to kill these mollusc pests [14].
  • Acetylcholine (ACh) and acetylcholinesterase (AChE) in central nervous system (CNS) and foot muscle (FM) of Laevicaulis alte cresting at 0400 h under LD 12:12 (0600 to 1800 : 1800 to 0600 h) regimen are in phase with each other [15].

Analytical, diagnostic and therapeutic context of ZBED1

  • Crystals of glutathione-S-transferase (GST)-fused protein containing the DNA-binding domain of DNA replication-related element-binding factor, DREF, were obtained under crystallization conditions similar to those for GST [16].
  • For electron beam reference dosimetry in radiotherapy, it is shown that by choosing the reference depth as dref = 0.6R(50)-0.1 cm, where R50 is the half-value depth in centimeters, the Spencer-Attix water-to-air stopping-power ratio at dref is given by (Llp)airw = 1.2534 - 0.1487 (R50)0.2144 [17].
  • CONCLUSION: The accuracy of digital subtraction angiography in renal artery interpretations is poor because of variations in evaluating both Dmin and Dref [3].
  • We studied the clinical manifestations of patients with a cervical esophagostomy and/or blind lower esophageal stump, which ruled out TC and/or proximal esophageal GER as a mechanism for AO/ALTE [18].
  • Many infants with a repaired esophageal atresia (EA) undergo fundoplication, aortopexy, or glossopexy because the mechanisms most responsible for airway obstruction and/or apparent life-threatening event (AO/ALTE) syndrome are considered to be gastroesophageal reflux (GER), tracheal compression (TC), or obstructive apnea, respectively [18].


  1. Frequency and timing of recurrent events in infants using home cardiorespiratory monitors. Côté, A., Hum, C., Brouillette, R.T., Themens, M. J. Pediatr. (1998) [Pubmed]
  2. Beta-ureidopropionase deficiency presenting with febrile status epilepticus. Assmann, B.E., Van Kuilenburg, A.B., Distelmaier, F., Abeling, N.G., Rosenbaum, T., Schaper, J., Duran, M., Mayatepek, E. Epilepsia (2006) [Pubmed]
  3. Interobserver variability in the interpretation of renal digital subtraction angiography. Paul, J.F., Cherrak, I., Jaulent, M.C., Chatellier, G., Plouin, P.F., Degoulet, P., Gaux, J.C. AJR. American journal of roentgenology. (1999) [Pubmed]
  4. Respiratory and arousal responses to hypoxia in apnoeic infants reinvestigated. Milerad, J., Hertzberg, T., Wennergren, G., Lagercrantz, H. Eur. J. Pediatr. (1989) [Pubmed]
  5. A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases. Esposito, T., Gianfrancesco, F., Ciccodicola, A., Montanini, L., Mumm, S., D'Urso, M., Forabosco, A. Hum. Mol. Genet. (1999) [Pubmed]
  6. Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. Ohshima, N., Takahashi, M., Hirose, F. J. Biol. Chem. (2003) [Pubmed]
  7. Low melatonin production in infants with a life-threatening event. Sivan, Y., Laudon, M., Kuint, J., Zisapel, N. Developmental medicine and child neurology. (2000) [Pubmed]
  8. Parental reported apnoea, admissions to hospital and sudden infant death syndrome. Mitchell, E.A., Thompson, J.M. Acta Paediatr. (2001) [Pubmed]
  9. The effect in vivo of crustacean eyestalk extracts on some aspects of carbohydrate metabolism in the slug Laevicaulis alte. Sreenivasula Reddy, P., Ramamurthi, R. Arch. Int. Physiol. Biochim. (1982) [Pubmed]
  10. A study on the effect of central nervous system homogenate on the carbohydrate metabolism in the land slug, Laevicaulis alte. Kulkarni, A.B. Riv. Biol. (1975) [Pubmed]
  11. Urinary tract infection presenting as an ALTE: report of three cases. Edwards, K.S., Gardner, T., Altman, R.L., Brand, D.A. Clinical pediatrics. (2004) [Pubmed]
  12. Cancer of the nose and paranasal sinuses in the metal industry: a case-control study. Comba, P., Barbieri, P.G., Battista, G., Belli, S., Ponterio, F., Zanetti, D., Axelson, O. British journal of industrial medicine. (1992) [Pubmed]
  13. Rhythmic succinate dehydrogenase activity in the slug, Laevicaulis alte (Ferussac, 1821). Pavan Kumar, T., Sivarami Reddy, N., Sasira Babu, K. Acta physiologica Polonica. (1982) [Pubmed]
  14. On the safe use of pesticides in controlling the terrestrial mollusc pests. Panigrahi, A., Raut, S.K. Mem. Inst. Oswaldo Cruz (1993) [Pubmed]
  15. Rhythm in acetylcholine-acetylcholinesterase system in the slug, Laevicaulis alte (Ferussac, 1821). Pavan Kumar, T., Murali Mohan, P., Sasira Babu, K. Acta physiologica Polonica. (1982) [Pubmed]
  16. Use of a fusion protein to obtain crystals suitable for X-ray analysis: crystallization of a GST-fused protein containing the DNA-binding domain of DNA replication-related element-binding factor, DREF. Kuge, M., Fujii, Y., Shimizu, T., Hirose, F., Matsukage, A., Hakoshima, T. Protein Sci. (1997) [Pubmed]
  17. R50 as a beam quality specifier for selecting stopping-power ratios and reference depths for electron dosimetry. Burns, D.T., Ding, G.X., Rogers, D.W. Medical physics. (1996) [Pubmed]
  18. Pathogenesis of apparent life-threatening events in infants with esophageal atresia. Cozzi, D.A., Zani, A., Conforti, A., Colarizi, P., Moretti, C., Cozzi, F. Pediatr. Pulmonol. (2006) [Pubmed]
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