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Gene Review

PPP1R14B  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: PHI-1, PLCB3N, PNG, Phospholipase C-beta-3 neighbouring gene protein, Protein phosphatase 1 regulatory subunit 14B, ...


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Disease relevance of PPP1R14B

  • It was shown from the present MD simulations that the torsion angles phi1 and phi4 of the C3 side chain showed the most dramatic change when compared with the ground-state receptor-bound conformation, indicating that rotation around these torsion angles is responsible for releasing the ligand strain energy [1].
  • A library of cDNA clones expressing proteins of the asexual blood stages of a Papua New Guinean isolate of Plasmodium falciparum (isolate FCQ27/PNG (FC27] was constructed in the bacteriophage vector lambda gt11-Amp3 [2].
  • We describe the isolation and expression of a murine homologue of the Phospholipase C beta3 Neighboring Gene (PNG), located in the MEN1 region on chromosome 11q13 [3].
  • A new O antibody titre of > or = 160 was recommended as a diagnostic titre for typhoid fever in PNG [4].
  • Mefloquine resistant P. vivax malaria in PNG [5].
  • PHI-1 gene copy number and expression are both decreased in colorectal carcinoma  [6] [7]

Psychiatry related information on PPP1R14B

  • 2) What are the existing programmes for the prevention and management of problems related to alcohol abuse in PNG [8]?
  • The second group consisted of mental health nurses and general nurses working in the capitals of the nineteen provinces and the National Capital District of PNG [8].

High impact information on PPP1R14B

  • The Ser/Thr phosphorylation of several signaling, cytoskeletal and focal-adhesion proteins was unchanged in PHI-1-depleted cells, so the target of PHI-1 inhibited protein-phosphatase 1 remains unidentified [9].
  • Immunostaining of brain sections for the specific inhibitor of type-1 protein Ser/Thr phosphatase called PHI-1 showed high expression levels in smooth muscle and especially in vascular endothelial cells [9].
  • Knockdown of PHI-1 using small interfering RNAs reduced by 45% the rate of HeLa cell migration in a wound-healing assay [9].
  • Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site [10].
  • Immunoblotting showed that PHI-1 was expressed in most animal tissues and several cell lines, and a second larger protein called PHI-2 was present in different muscles, especially cardiac muscle [11].

Chemical compound and disease context of PPP1R14B

  • The minimal model method was used to assess insulin sensitivity, S(I), and first-phase (phi1) and second-phase (phi2) beta-cell sensitivity from plasma glucose, insulin, and C-peptide concentrations measured during an intravenous glucose tolerance test ([IVGTT] 0.33 g/kg body weight) [12].

Biological context of PPP1R14B

  • We describe the isolation, characterization, and genomic structure of a gene, Phospholipase C beta 3 Neighboring gene (PNG), located on chromosome 11q13 [13].
  • LPH-catalyzed PNG hydrolysis in vitro is competitively inhibited by lactose [14].
  • Pyridoxine-5'-beta-D-glucoside (PNG) is a major form of vitamin B-6 in plant foods that exhibits partial bioavailability as vitamin B-6 in humans [15].
  • To assess the metabolic utilization of PNG during pregnancy and the availability to the fetus, [3H]PNG and [14C]pyridoxine (PN) were orally administered to 15-d pregnant rats for direct assessment of the intestinal absorption, tissue distribution, and urinary excretion of the radioisotopes [16].
  • To define whether the glycosylation was important process for its secretion, endoglycosidase H (Endo H) and PNGase F (PNG F) were employed to evaluate the effect of glycosylation types on secretion of hPAP21 [17].

Anatomical context of PPP1R14B


Associations of PPP1R14B with chemical compounds

  • The computer-assisted analysis of glucose, insulin, and C-peptide profiles obtained from frequently sampled intravenous glucose tolerance tests allows to achieve an integrated view of factors controlling glucose tolerance, i.e., insulin sensitivity (SI), first and second phase insulin secretion (phi1 and phi2) [19].
  • Intracellular PNG concentration was not significantly reduced in the presence of lactose, but the concentration of PL declined in proportion to extracellular lactose (P = 0.01) [14].
  • Pyridoxine-5'-beta-D-glucoside (PNG), which is abundant in various plant-derived food products, has been shown to be poorly utilized in male rats and adult men [16].
  • An important dietary source of vitamin B-6, pyridoxine-5'-beta-D-glucoside (PNG), exhibits only partial bioavailability, which is limited by the extent of enzymatic cleavage of the beta-glucosidic bond to release metabolically available pyridoxine (PN) [14].
  • Increasing PNG concentration in the medium did not change intracellular concentrations of PN, pyridoxamine (PM), pyridoxamine 5'-phosphate (PMP), or pyridoxal 5'-phosphate (PLP); however, intracellular pyridoxal (PL) concentration increased [14].

Other interactions of PPP1R14B


Analytical, diagnostic and therapeutic context of PPP1R14B

  • A preliminary survey for the natural occurrence of Fusarium mycotoxins--nivalenol (NIV), deoxynivalenol (DON) and zearalenone (ZEN)--in cereals imported mostly from Australia to Papua, New Guinea (PNG) in 1991 was carried out by TLC, GLC, and HPLC analysis [22].
  • It is concluded that use of this heat-stable vaccine is possible with existing cold chain facilities in PNG and that infants can be vaccinated from the age of 9 months [23].


  1. Steric trigger as a mechanism for CB1 cannabinoid receptor activation. Shim, J.Y., Howlett, A.C. Journal of chemical information and computer sciences. (2004) [Pubmed]
  2. The expression of Plasmodium falciparum bloodstage antigens in Escherichia coli. Brown, G.V., Anders, R.F., Coppel, R.L., Saint, R.B., Cowman, A.F., Stahl, H.D., Lingelbach, K.R., Mitchell, G.F., Alpers, M.P., Kemp, D.J. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1984) [Pubmed]
  3. Sequence and expression of the mouse homologue to human phospholipase C beta3 neighboring gene. Lagercrantz, J., Kedra, D., Carson, E., Nordenskjöld, M., Dumanski, J.P., Weber, G., Piehl, F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  4. Re-evaluation of the Widal agglutination test in response to the changing pattern of typhoid fever in the highlands of Papua New Guinea. Clegg, A., Passey, M., Omena, M., Karigifa, K., Suve, N. Acta Trop. (1994) [Pubmed]
  5. Mefloquine resistant P. vivax malaria in PNG. Amor, D., Richards, M. Med. J. Aust. (1992) [Pubmed]
  6. Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma. Kurashina, K., Yamashita, Y., Ueno, T., Koinuma, K., Ohashi, J., Horie, H., Miyakura, Y., Hamada, T., Haruta, H., Hatanaka, H., Soda, M., Choi, Y.L., Takada, S., Yasuda, Y., Nagai, H., Mano, H. Cancer. Sci. (2008) [Pubmed]
  7. Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. Gaedcke, J., Grade, M., Jung, K., Camps, J., Jo, P., Emons, G., Gehoff, A., Sax, U., Schirmer, M., Becker, H., Beissbarth, T., Ried, T., Ghadimi, B.M. Genes. Chromosomes. Cancer. (2010) [Pubmed]
  8. Prevention and management of problems related to alcohol abuse in Papua New Guinea through primary health care. Johnson, F.Y. Medicine and law. (1989) [Pubmed]
  9. Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. Tountas, N.A., Brautigan, D.L. J. Cell. Sci. (2004) [Pubmed]
  10. Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. Blay, W.M., Gnanakaran, S., Foley, B., Doria-Rose, N.A., Korber, B.T., Haigwood, N.L. J. Virol. (2006) [Pubmed]
  11. A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. Eto, M., Karginov, A., Brautigan, D.L. Biochemistry (1999) [Pubmed]
  12. Visceral adipose tissue impairs insulin secretion and insulin sensitivity but not energy expenditure in obesity. Macor, C., Ruggeri, A., Mazzonetto, P., Federspil, G., Cobelli, C., Vettor, R. Metab. Clin. Exp. (1997) [Pubmed]
  13. Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. Lagercrantz, J., Carson, E., Larsson, C., Nordenskjöld, M., Weber, G. Genomics (1996) [Pubmed]
  14. Uptake, hydrolysis, and metabolism of pyridoxine-5'-beta-D-glucoside in Caco-2 cells. Mackey, A.D., McMahon, R.J., Townsend, J.H., Gregory, J.F. J. Nutr. (2004) [Pubmed]
  15. Intestinal brush border membrane catalyzes hydrolysis of pyridoxine-5'-beta-D-glucoside and exhibits parallel developmental changes of hydrolytic activities toward pyridoxine-5'-beta-D-glucoside and lactose in rats. Armada, L.J., Mackey, A.D., Gregory, J.F. J. Nutr. (2002) [Pubmed]
  16. Pyridoxine-5'-beta-D-glucoside: metabolic utilization in rats during pregnancy and availability to the fetus. Cheng, S., Trumbo, P.R. J. Nutr. (1993) [Pubmed]
  17. N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21. Zhou, Y.B., Liu, F., Zhu, Z.D., Zhu, H., Zhang, X., Wang, Z.Q., Liu, J.H., Han, Z.G. FEBS Lett. (2004) [Pubmed]
  18. Amino acid sequences recognized by T cells: studies on a merozoite surface antigen from the FCQ-27/PNG isolate of Plasmodium falciparum. Rzepczyk, C.M., Csurhes, P.A., Baxter, E.P., Doran, T.J., Irving, D.O., Kere, N. Immunol. Lett. (1990) [Pubmed]
  19. Major influence of liver function itself but not of immunosuppression determines glucose tolerance after living-donor liver transplantation. Stockmann, M., Konrad, T., Nolting, S., Hünerbein, D., Wernecke, K.D., Döbling, H., Steinmüller, T., Neuhaus, P. Liver Transpl. (2006) [Pubmed]
  20. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. MacDonald, J.A., Eto, M., Borman, M.A., Brautigan, D.L., Haystead, T.A. FEBS Lett. (2001) [Pubmed]
  21. PHI-1 interacts with the catalytic subunit of myosin light chain phosphatase to produce a Ca(2+) independent increase in MLC(20) phosphorylation and force in avian smooth muscle. El-Toukhy, A., Given, A.M., Ogut, O., Brozovich, F.V. FEBS Lett. (2006) [Pubmed]
  22. Occurrence of nivalenol, deoxynivalenol, and zearalenone in imported cereals in Papua, New Guinea. Yuwai, K.E., Rao, K.S., Singh, K., Tanaka, T., Ueno, Y. Nat. Toxins (1994) [Pubmed]
  23. Field trial of a heat-stable measles vaccine in Papua New Guinea. Climie, A., André, F.E. The Journal of tropical medicine and hygiene. (1984) [Pubmed]
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