Disease relevance of PPP1R14B

• It was shown from the present MD simulations that the torsion angles phi1 and phi4 of the C3 side chain showed the most dramatic change when compared with the ground-state receptor-bound conformation, indicating that rotation around these torsion angles is responsible for releasing the ligand strain energy [1].
• A library of cDNA clones expressing proteins of the asexual blood stages of a Papua New Guinean isolate of Plasmodium falciparum (isolate FCQ27/PNG (FC27] was constructed in the bacteriophage vector lambda gt11-Amp3 [2].
• We describe the isolation and expression of a murine homologue of the Phospholipase C beta3 Neighboring Gene (PNG), located in the MEN1 region on chromosome 11q13 [3].
• A new O antibody titre of > or = 160 was recommended as a diagnostic titre for typhoid fever in PNG [4].
• Mefloquine resistant P. vivax malaria in PNG [5].
• PHI-1 gene copy number and expression are both decreased in colorectal carcinoma  [6] [7]

Psychiatry related information on PPP1R14B

• 2) What are the existing programmes for the prevention and management of problems related to alcohol abuse in PNG [8]?
• The second group consisted of mental health nurses and general nurses working in the capitals of the nineteen provinces and the National Capital District of PNG [8].

High impact information on PPP1R14B

• The Ser/Thr phosphorylation of several signaling, cytoskeletal and focal-adhesion proteins was unchanged in PHI-1-depleted cells, so the target of PHI-1 inhibited protein-phosphatase 1 remains unidentified [9].
• Immunostaining of brain sections for the specific inhibitor of type-1 protein Ser/Thr phosphatase called PHI-1 showed high expression levels in smooth muscle and especially in vascular endothelial cells [9].
• Knockdown of PHI-1 using small interfering RNAs reduced by 45% the rate of HeLa cell migration in a wound-healing assay [9].
• Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site [10].
• Immunoblotting showed that PHI-1 was expressed in most animal tissues and several cell lines, and a second larger protein called PHI-2 was present in different muscles, especially cardiac muscle [11].

Chemical compound and disease context of PPP1R14B

• The minimal model method was used to assess insulin sensitivity, S(I), and first-phase (phi1) and second-phase (phi2) beta-cell sensitivity from plasma glucose, insulin, and C-peptide concentrations measured during an intravenous glucose tolerance test ([IVGTT] 0.33 g/kg body weight) [12].

Biological context of PPP1R14B

• We describe the isolation, characterization, and genomic structure of a gene, Phospholipase C beta 3 Neighboring gene (PNG), located on chromosome 11q13 [13].
• LPH-catalyzed PNG hydrolysis in vitro is competitively inhibited by lactose [14].
• Pyridoxine-5'-beta-D-glucoside (PNG) is a major form of vitamin B-6 in plant foods that exhibits partial bioavailability as vitamin B-6 in humans [15].
• To assess the metabolic utilization of PNG during pregnancy and the availability to the fetus, [3H]PNG and [14C]pyridoxine (PN) were orally administered to 15-d pregnant rats for direct assessment of the intestinal absorption, tissue distribution, and urinary excretion of the radioisotopes [16].
• To define whether the glycosylation was important process for its secretion, endoglycosidase H (Endo H) and PNGase F (PNG F) were employed to evaluate the effect of glycosylation types on secretion of hPAP21 [17].

Anatomical context of PPP1R14B

• Brush border activities toward PNG and lactose and were closely correlated (r = 0.84; P < 0.0001) [15].
• In vitro specific activities toward PNG and lactose were greater in brush border than cytosol, and these were greater in newborn rats than in all other age groups (P < 0.01) [15].
• Northern blots with mouse PNG probes revealed expression of a 1 kb message in multiple tissues, and an additional 2.3 kb band in testis [3].
• Amino acid sequences recognized by T cells: studies on a merozoite surface antigen from the FCQ-27/PNG isolate of Plasmodium falciparum [18].
• Twenty-six overlapping peptides, spanning the entire FCQ-27/PNG sequence of the Plasmodium falciparum antigen known as merozoite surface antigen 2 were screened for their ability to induce the proliferation of peripheral blood lymphocytes (PBL) obtained from 12 donors living in Honiara, Solomon Islands where P. falciparum is endemic [18].

Associations of PPP1R14B with chemical compounds

• The computer-assisted analysis of glucose, insulin, and C-peptide profiles obtained from frequently sampled intravenous glucose tolerance tests allows to achieve an integrated view of factors controlling glucose tolerance, i.e., insulin sensitivity (SI), first and second phase insulin secretion (phi1 and phi2) [19].
• Intracellular PNG concentration was not significantly reduced in the presence of lactose, but the concentration of PL declined in proportion to extracellular lactose (P = 0.01) [14].
• Pyridoxine-5'-beta-D-glucoside (PNG), which is abundant in various plant-derived food products, has been shown to be poorly utilized in male rats and adult men [16].
• An important dietary source of vitamin B-6, pyridoxine-5'-beta-D-glucoside (PNG), exhibits only partial bioavailability, which is limited by the extent of enzymatic cleavage of the beta-glucosidic bond to release metabolically available pyridoxine (PN) [14].
• Increasing PNG concentration in the medium did not change intracellular concentrations of PN, pyridoxamine (PM), pyridoxamine 5'-phosphate (PMP), or pyridoxal 5'-phosphate (PLP); however, intracellular pyridoxal (PL) concentration increased [14].

Other interactions of PPP1R14B

• Phosphorylation of CPI-17 and PHI-1 by the MYPT1-associated kinase (M110 kinase) was investigated [20].
• In avian smooth muscles, GTPgammaS produces a Rho kinase mediated increase in PHI-1 phosphorylation and force, but whether this correlation is causal is unknown [21].

Analytical, diagnostic and therapeutic context of PPP1R14B

• A preliminary survey for the natural occurrence of Fusarium mycotoxins--nivalenol (NIV), deoxynivalenol (DON) and zearalenone (ZEN)--in cereals imported mostly from Australia to Papua, New Guinea (PNG) in 1991 was carried out by TLC, GLC, and HPLC analysis [22].
• It is concluded that use of this heat-stable vaccine is possible with existing cold chain facilities in PNG and that infants can be vaccinated from the age of 9 months [23].

References