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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Preleukemia


High impact information on Preleukemia


Chemical compound and disease context of Preleukemia


Biological context of Preleukemia


Anatomical context of Preleukemia


Gene context of Preleukemia

  • Since the GATA1 mutations were restricted to DS-AMKL, we also investigated whether GATA1 was altered in the "preleukemia" of DS, transient myeloproliferative disorder (TMD) [20].
  • The present results indicate that murine radiation induced AML is a multiphase process involving radiation induced preleukemia that can be promoted by different treatments [21].
  • They represent the time when AML cells are replacing preleukemia cells; (2) monoclonal hemopoiesis and RA/RARS represent a variety of clinical syndromes with a common appearance but with different evolutionary potential; (3) malignant cells alter the fitness landscape enhancing their proliferative advantage [22].
  • Possible retroviral origin of prion disease: could prion disease be reconsidered as a preleukemia syndrome [23]?
  • The results suggest that PSK could be used as a prophylactic immune response modifier in preleukemia [24].


  1. Leukemia and preleukemia after adjuvant treatment of gastrointestinal cancer with semustine (methyl-CCNU). Boice, J.D., Greene, M.H., Killen, J.Y., Ellenberg, S.S., Keehn, R.J., McFadden, E., Chen, T.T., Fraumeni, J.F. N. Engl. J. Med. (1983) [Pubmed]
  2. Increased expression of p53 protein in human leukemia cells. Koeffler, H.P., Miller, C., Nicolson, M.A., Ranyard, J., Bosselman, R.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. S1 nuclease analysis of alpha-globin gene expression in preleukemic patients with acquired hemoglobin H disease after transfer to mouse erythroleukemia cells. Helder, J., Deisseroth, A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Clinical features and molecular analysis of acquired hemoglobin H disease. Higgs, D.R., Wood, W.G., Barton, C., Weatherall, D.J. Am. J. Med. (1983) [Pubmed]
  5. Steroid-induced tumor lysis syndrome in a patient with preleukemia. Yang, S.S., Chau, T., Dai, M.S., Lin, S.H. Clin. Nephrol. (2003) [Pubmed]
  6. Response of preleukemic syndromes to continuous infusion of low-dose cytarabine. Wisch, J.S., Griffin, J.D., Kufe, D.W. N. Engl. J. Med. (1983) [Pubmed]
  7. Treatment of premalignancy: prevention of lymphoma in radiation leukemia virus-inoculated mice by cyclosporin A and immunotoxin. Yefenof, E., Abboud, G., Epszteyn, S., Vitetta, E.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Increased responses to lymphokines are correlated with preleukemia in mice inoculated with Moloney leukemia virus. Lee, J.C., Ihle, J.N. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  9. Treatment of preleukemic syndromes with continuous intravenous infusion of low-dose cytosine arabinoside. Griffin, J.D., Spriggs, D., Wisch, J.S., Kufe, D.W. J. Clin. Oncol. (1985) [Pubmed]
  10. Treatment-related cancers after gynecologic malignancy. Tucker, M.A., Fraumeni, J.F. Cancer (1987) [Pubmed]
  11. Vitamin A derivatives in the prevention and treatment of human cancer. Lippman, S.M., Meyskens, F.L. Journal of the American College of Nutrition. (1988) [Pubmed]
  12. High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer. Andersson, M., Philip, P., Pedersen-Bjergaard, J. Cancer (1990) [Pubmed]
  13. Vitamin C in leukemia and preleukemia cell growth. Park, C.H. Prog. Clin. Biol. Res. (1988) [Pubmed]
  14. Cloning and characterization of human histone deacetylase 8. Van den Wyngaert, I., de Vries, W., Kremer, A., Neefs, J., Verhasselt, P., Luyten, W.H., Kass, S.U. FEBS Lett. (2000) [Pubmed]
  15. Preleukemia and leukemia with 12p- and 19q+ chromosome alterations following Alkeran therapy. Wilmoth, D., Feder, M., Finan, J., Nowell, P. Cancer Genet. Cytogenet. (1985) [Pubmed]
  16. The preleukemic syndromes (hematopoietic dysplasia) in childhood. Kleihauer, E. Eur. J. Pediatr. (1980) [Pubmed]
  17. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Kawabata, H., Nakamaki, T., Ikonomi, P., Smith, R.D., Germain, R.S., Koeffler, H.P. Blood (2001) [Pubmed]
  18. Leukemia and preleukemia in Fanconi anemia patients. A review of the literature and report of the International Fanconi Anemia Registry. Auerbach, A.D., Allen, R.G. Cancer Genet. Cytogenet. (1991) [Pubmed]
  19. Effect of thymopoietin and interleukin 2 on depressed mitogenic responsiveness and colony formation of lymphocytes from patients with preleukemia. Knox, S.J., Rosenblatt, L.S., Anderson, R.W., Greenberg, B.R. Thymus (1986) [Pubmed]
  20. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Greene, M.E., Mundschau, G., Wechsler, J., McDevitt, M., Gamis, A., Karp, J., Gurbuxani, S., Arceci, R., Crispino, J.D. Blood Cells Mol. Dis. (2003) [Pubmed]
  21. Initiation and promotion in radiation-induced myeloid leukemia. Haran-Ghera, N., Peled, A., Krautghamer, R., Resnitzky, P. Leukemia (1992) [Pubmed]
  22. Fitness landscapes and the myeloid leukemias. Preisler, H.D. Leuk. Res. (1999) [Pubmed]
  23. Possible retroviral origin of prion disease: could prion disease be reconsidered as a preleukemia syndrome? Labat, M.L. Biomed. Pharmacother. (1999) [Pubmed]
  24. Potentiation of T cell immunity against radiation-leukemia-virus-induced lymphoma by polysaccharide K. Yefenof, E., Einat, E., Klein, E. Cancer Immunol. Immunother. (1991) [Pubmed]
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