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MeSH Review

Needlestick Injuries

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Disease relevance of Needlestick Injuries


Psychiatry related information on Needlestick Injuries


High impact information on Needlestick Injuries

  • Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure [8].
  • Failed prophylactic zidovudine after needlestick injury [9].
  • To assess the risk to hospital personnel of acquiring an hepatitis C virus (HCV) infection as a result of occupational exposure to needle-stick injuries, 81 employees who had parenteral exposure to an anti-HCV-positive source were followed for 12 months [10].
  • In samples from the IV line there was a linear increase in IL-6 levels in both conditions, whereas the amount of IL-6 detected in the needle stick sample at the end did not differ from baseline [11].
  • This finding raises the possibility that treatment with low-dose IFN following an accidental needlestick may be beneficial, even when it is started after the clinical onset of hepatitis [12].

Chemical compound and disease context of Needlestick Injuries

  • OBJECTIVE: To determine whether pretreatment of skin with erbium:YAG (Er:YAG) laser-assisted delivery facilitates the penetration of lidocaine cream to provide anesthesia suitable for needlesticks after just 5 minutes [13].
  • Accidental needlesticks in the phlebotomy service of the Department of Laboratory Medicine and Pathology at Mayo Clinic Rochester [14].
  • Four injections of 1 mL epinephrine 1:10000 at 1 mm from the spurting artery (n = 7) were compared to four injections of normal saline solution 1 to 5 mL (n = 12) and to four dry needle sticks (n = 9) [15].
  • Re-use of injection materials without sterilization, accidental needle-stick injuries among health care workers, and injection-related abscesses in patients were common in countries in the WHO African Region [16].
  • Analysis of events leading to needlestick-related exposures revealed that the heparin lock intermittent intravenous procedure was involved in 26%; recapping accounted for 17%; improper disposal, 15%; manipulating equipment, 14%; phlebotomy, 12%; and other needlestick events, 16% [17].

Biological context of Needlestick Injuries


Anatomical context of Needlestick Injuries


Gene context of Needlestick Injuries

  • Control levels of IL-6, TNF-alpha and sTNF-R p75 measured in plasma obtained by needle stick after 10 h did not differ from baseline, and those of sTNF-R p55 were even higher [22].
  • A 25-year-old male physician with acute hepatitis C after needle-stick injury was treated with combination therapy including twice-a-day interferon-beta (IFN-beta) and standard interferon-alpha (IFN-alpha) [23].
  • In contrast, sequences from the needle-stick case showed only 67% and 80% amino acid identity in env and gag, respectively, and were separated on a phylogenetic tree [24].
  • These data indicate a significant increase in plasma PRL and HVA in children following needle stick which gradually decreases over a 1.5-2-h period [25].
  • These results were remarkably increased by using the second generation assay (92% in post-transfusion AH, 72% in sporadic AH, 100% in needlestick exposed AH, 96% in CH, 96% in LC and 97% in HCC) [5].

Analytical, diagnostic and therapeutic context of Needlestick Injuries

  • METHODS: Sixty subjects evaluated the effectiveness of a lidocaine-containing bioadhesive patch, or L-BP, to alleviate pain caused by needlesticks, or Ns, with or without injection, and with scaling and root planing, or Sc/RP, instrumentation [26].


  1. Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood. The CDC Cooperative Needlestick Surveillance Group. Tokars, J.I., Marcus, R., Culver, D.H., Schable, C.A., McKibben, P.S., Bandea, C.I., Bell, D.M. Ann. Intern. Med. (1993) [Pubmed]
  2. Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis virus infection. Okamoto, H., Tsuda, F., Machida, A., Munekata, E., Akahane, Y., Sugai, Y., Mashiko, K., Mitsui, T., Tanaka, T., Miyakawa, Y. Hepatology (1992) [Pubmed]
  3. Transmission routes and clinical courses in sporadic acute hepatitis C. Sata, M., Hashimoto, O., Noguchi, S., Uchimura, Y., Akiyoshi, F., Matsukuma, N., Fukushima, H., Suzuki, H., Kage, M., Kojiro, M., Tanikawa, K. J. Viral Hepat. (1997) [Pubmed]
  4. Transmission of scrub typhus by needlestick from a patient receiving pefloxacin. Jee, H.G., Chung, M.H., Lee, S.G., Kim, I.S., Chang, W.H. Scand. J. Infect. Dis. (1996) [Pubmed]
  5. Clinical evaluation of a newly established anti-HCV assay for the diagnosis of hepatitis C in Japan. Ishiguro, N., Tomimatsu, M., Nagahara, H., Obata, H. J. Gastroenterol. Hepatol. (1992) [Pubmed]
  6. Should surgical patients be screened for human immunodeficiency virus infection? Shanson, D.C. J. Hosp. Infect. (1991) [Pubmed]
  7. Preventive health behaviour among general practitioners in Victoria. McCall, L., Maher, T., Piterman, L. Australian family physician. (1999) [Pubmed]
  8. Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure. Alter, H.J., Seeff, L.B., Kaplan, P.M., McAuliffe, V.J., Wright, E.C., Gerin, J.L., Purcell, R.H., Holland, P.V., Zimmerman, H.J. N. Engl. J. Med. (1976) [Pubmed]
  9. Failed prophylactic zidovudine after needlestick injury. Looke, D.F., Grove, D.I. Lancet (1990) [Pubmed]
  10. Risk of needle-stick injuries in the transmission of hepatitis C virus in hospital personnel. Hernandez, M.E., Bruguera, M., Puyuelo, T., Barrera, J.M., Sanchez Tapias, J.M., Rodés, J. J. Hepatol. (1992) [Pubmed]
  11. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures. Haack, M., Kraus, T., Schuld, A., Dalal, M., Koethe, D., Pollmächer, T. Psychoneuroendocrinology (2002) [Pubmed]
  12. Early therapy with interferon for acute hepatitis C acquired through a needlestick. Noguchi, S., Sata, M., Suzuki, H., Ohba, K., Mizokami, M., Tanikawa, K. Clin. Infect. Dis. (1997) [Pubmed]
  13. Laser-assisted penetration of topical anesthetic in adults. Baron, E.D., Harris, L., Redpath, W.S., Shapiro, H., Hetzel, F., Morley, G., Bar-Or, D., Stevens, S.R. Archives of dermatology. (2003) [Pubmed]
  14. Accidental needlesticks in the phlebotomy service of the Department of Laboratory Medicine and Pathology at Mayo Clinic Rochester. Dale, J.C., Pruett, S.K., Maker, M.D. Mayo Clin. Proc. (1998) [Pubmed]
  15. Prolonged evaluation of epinephrine and normal saline solution injections in an acute ulcer model with a single bleeding artery. Pinkas, H., McAllister, E., Norman, J., Robinson, B., Brady, P.G., Dawson, P.J. Gastrointest. Endosc. (1995) [Pubmed]
  16. Safety of immunization injections in Africa: not simply a problem of logistics. Dicko, M., Oni, A.Q., Ganivet, S., Kone, S., Pierre, L., Jacquet, B. Bull. World Health Organ. (2000) [Pubmed]
  17. Determinants of blood and body fluid exposure in a large teaching hospital: hazards of the intermittent intravenous procedure. Yassi, A., McGill, M. American journal of infection control. (1991) [Pubmed]
  18. Pre-synaptic modulation of quadriceps arthrogenic muscle inhibition. Palmieri, R.M., Weltman, A., Edwards, J.E., Tom, J.A., Saliba, E.N., Mistry, D.J., Ingersoll, C.D. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. (2005) [Pubmed]
  19. Needlestick injuries among female veterinarians: frequency, syringe contents and side-effects. Wilkins, J.R., Bowman, M.E. Occupational medicine (Oxford, England) (1997) [Pubmed]
  20. Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine. Abu Al-Melh, M., Andersson, L., Behbehani, E. The Journal of clinical dentistry. (2005) [Pubmed]
  21. New vascular sheath for subcutaneous drug administration: design, animal testing, and clinical application for pain prevention after angioplasty. Lambert, C.R., Bikkina, M., Shakoor, A., Korzun, W.J. Catheterization and cardiovascular diagnosis. (1996) [Pubmed]
  22. Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men. Haack, M., Reichenberg, A., Kraus, T., Schuld, A., Yirmiya, R., Pollmächer, T. Cytokine (2000) [Pubmed]
  23. Complete response to twice-a-day interferon-beta with standard interferon-alpha therapy in acute hepatitis C after a needle-stick. Oketani, M., Higashi, T., Yamasaki, N., Shinmyozu, K., Osame, M., Arima, T. J. Clin. Gastroenterol. (1999) [Pubmed]
  24. Molecular investigation of two possible cases of accidental HIV-1 transmission in South Africa. Bredell, H., Crookes, R.L., du P Heynes, A., Schoub, B.D., Morris, L. AIDS Res. Hum. Retroviruses (2003) [Pubmed]
  25. Changes in plasma prolactin and catecholamine metabolite levels following acute needle stick in children. Grayson, R.H., Halperin, J.M., Sharma, V., Schwartz, S.T., Koda, V.H., Newcorn, J.H. Psychiatry research. (1997) [Pubmed]
  26. Evaluation of a transoral delivery system for topical anesthesia. Carr, M.P., Horton, J.E. Journal of the American Dental Association (1939) (2001) [Pubmed]
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