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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of H-Reflex


Psychiatry related information on H-Reflex


High impact information on H-Reflex

  • Other abnormalities included long-latency responses in the extremities in 2 patients, release of H-reflexes from flexor hallucis brevis muscle in 2 patients, and an Hmax/Mmax ratio of 98% in 2 patients [8].
  • In the former cases, the size of the H' reflex evoked by the same conditioning H1 discharge was further depressed after L-acetylcarnitine, pointing to a potentiating effect of the drug on Renshaw cells; in the latter cases no such effect was seen [9].
  • Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture [10].
  • In one patient, we repeated the H-reflex tests twice after withdrawal of levodopa [11].
  • Baclofen abolished the concomitantly recorded H-reflex and markedly suppressed the P wave amplitude and area [12].

Chemical compound and disease context of H-Reflex


Biological context of H-Reflex


Anatomical context of H-Reflex


Associations of H-Reflex with chemical compounds

  • After smoking the nicotine-containing cigarettes, the subjects showed a reduction of the H reflex recovery cycle [28].
  • 2. Distinct differences were observed between the modifications of the test reflex and those of the reference H-reflex during both tonic and phasic voluntary contractions [29].
  • 3. Injections of lobeline at doses sufficient to evoke respiratory discomfort lasting 25-32 s (37-73 microgram kg-1) increased the size of the H reflex in soleus with an onset latency of about 10 s and lasting about 20 s [30].
  • The effects of subarachnoid injection of Conray (methylglucamine iothalamate) and its dimer (methylglucamine locarmate) in various concentrations were compared using electrophysiological monitors of the cortical evoked response (CER) and the H-reflex [31].
  • Effects of propofol on H-reflex in humans [32].

Gene context of H-Reflex

  • Abnormalities in CMCT may be the third electrophysiological diagnostic criterion in FA, after reduced amplitude of nerve action potentials and absent H reflex [33].
  • Dopa-responsive dystonia and normalization of soleus H-reflex test results with treatment [11].
  • As hypothesised, slopes of linear regressions fitted to H-reflex versus EMG data were independent of gravity for walking and running (ANOVA, P > 0.8) [34].
  • However, abolition of the H reflex and F waves during REM sleep has also been reported [35].
  • 1. H reflexes were elicited in the small muscles of the foot in the canine and human during passive locomotor-like rotation of the shank about the ipsilateral knee [36].

Analytical, diagnostic and therapeutic context of H-Reflex


  1. H-reflex recovery curve and reciprocal inhibition of H-reflex in different kinds of dystonia. Panizza, M., Lelli, S., Nilsson, J., Hallett, M. Neurology (1990) [Pubmed]
  2. Reciprocal inhibition between forearm muscles in spastic hemiplegia. Artieda, J., Quesada, P., Obeso, J.A. Neurology (1991) [Pubmed]
  3. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Hiersemenzel, L.P., Curt, A., Dietz, V. Neurology (2000) [Pubmed]
  4. Effect of spinal cord injury severity on alterations of the H-reflex. Lee, J.K., Emch, G.S., Johnson, C.S., Wrathall, J.R. Exp. Neurol. (2005) [Pubmed]
  5. Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders. Metz, J.T., Holcomb, H.H., Meltzer, H.Y. Biol. Psychiatry (1988) [Pubmed]
  6. Evidence favouring presynaptic inhibition between antagonist muscle afferents in the human forearm. Berardelli, A., Day, B.L., Marsden, C.D., Rothwell, J.C. J. Physiol. (Lond.) (1987) [Pubmed]
  7. Changes in spinal excitability during choice reaction time: the H reflex as a probe of information transmission. Hasbroucq, T., Akamatsu, M., Burle, B., Bonnet, M., Possamaï, C.A. Psychophysiology. (2000) [Pubmed]
  8. Periodic leg movements of sleep (nocturnal myoclonus): an electrophysiological study. Wechsler, L.R., Stakes, J.W., Shahani, B.T., Busis, N.A. Ann. Neurol. (1986) [Pubmed]
  9. Involvement of spinal recurrent inhibition in spasticity. Further insight into the regulation of Renshaw cell activity. Mazzocchio, R., Rossi, A. Brain (1997) [Pubmed]
  10. Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. Koelman, J.H., Hilgevoord, A.A., Bour, L.J., Speelman, J.D., Ongerboer de Visser, B.W. Neurology (1999) [Pubmed]
  11. Dopa-responsive dystonia and normalization of soleus H-reflex test results with treatment. Koelman, J.H., Speelman, J.D., Hilgevoord, A.A., Bour, L.J., Ongerboer de Visser, B.W. Neurology (1995) [Pubmed]
  12. Effects of intrathecal baclofen on lumbosacral and cortical somatosensory evoked potentials. Kofler, M., Donovan, W.H., Loubser, P.G., Berić, A. Neurology (1992) [Pubmed]
  13. Conditioning of the H reflex by stimulation of the posterior tibial nerve in Parkinson's disease. Martinelli, P., Montagna, P. J. Neurol. Neurosurg. Psychiatr. (1979) [Pubmed]
  14. Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain. Chabal, C., Jacobson, L., Little, J. Anesthesiology (1989) [Pubmed]
  15. Nitrous oxide depresses the H-reflex in children with cerebral palsy. Soriano, S.G., Logigian, E.L., Scott, R.M., Prahl, P.A., Madsen, J.R. Anesth. Analg. (1995) [Pubmed]
  16. Electrophysiological assessment of the effect of intrathecal baclofen in spastic children. Dachy, B., Dan, B. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2002) [Pubmed]
  17. Pre-synaptic modulation of quadriceps arthrogenic muscle inhibition. Palmieri, R.M., Weltman, A., Edwards, J.E., Tom, J.A., Saliba, E.N., Mistry, D.J., Ingersoll, C.D. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. (2005) [Pubmed]
  18. Effects of intrathecal fentanyl and lidocaine on somatosensory-evoked potentials, the H-reflex, and clinical responses. Chabal, C., Jacobson, L., Little, J. Anesth. Analg. (1988) [Pubmed]
  19. Surface recording of the H-reflex of the flexor carpi radialis. Jabre, J.F. Muscle Nerve (1981) [Pubmed]
  20. Trial-to-trial fluctuations in H-reflexes and motor evoked potentials in human wrist flexor. Funase, K., Miles, T.S., Gooden, B.R. Neurosci. Lett. (1999) [Pubmed]
  21. Methodological implications of the post activation depression of the soleus H-reflex in man. Crone, C., Nielsen, J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1989) [Pubmed]
  22. GAA trinucleotide repeat expansion in variant Friedreich's ataxia families. Cruz-Martínez, A., Anciones, B., Palau, F. Muscle Nerve (1997) [Pubmed]
  23. Involuntary movements and abnormal spontaneous EMG activity in syringomyelia and syringobulbia. Nogués, M.A., Leiguarda, R.C., Rivero, A.D., Salvat, F., Manes, F. Neurology (1999) [Pubmed]
  24. H-reflex in nonhomonymous muscles in the human forearm. Panizza, M., Lelli, S., Hallett, M. Neurology (1989) [Pubmed]
  25. Reciprocal inhibition between the muscles of the human forearm. Day, B.L., Marsden, C.D., Obeso, J.A., Rothwell, J.C. J. Physiol. (Lond.) (1984) [Pubmed]
  26. Modulation of spinal excitability during observation of hand actions in humans. Baldissera, F., Cavallari, P., Craighero, L., Fadiga, L. Eur. J. Neurosci. (2001) [Pubmed]
  27. Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action. Azouvi, P., Roby-Brami, A., Biraben, A., Thiebaut, J.B., Thurel, C., Bussel, B. J. Neurol. Neurosurg. Psychiatr. (1993) [Pubmed]
  28. Effects of tobacco smoking on the Hoffmann reflex. Kadoya, C., Matsuoka, S., Domino, E.F. Neuropsychopharmacology (1993) [Pubmed]
  29. Changes in recurrent inhibition during voluntary soleus contractions in man studied by an H-reflex technique. Hultborn, H., Pierrot-Deseilligny, E. J. Physiol. (Lond.) (1979) [Pubmed]
  30. Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres. Gandevia, S.C., Butler, J.E., Taylor, J.L., Crawford, M.R. J. Physiol. (Lond.) (1998) [Pubmed]
  31. Evaluation of the neurotoxicity of water-soluble myelographic contrast agents by electrophysiological monitors. Allen, W.E., VanGilder, J.C., Collins, W.F. Radiology. (1976) [Pubmed]
  32. Effects of propofol on H-reflex in humans. Kerz, T., Hennes, H.J., Fève, A., Decq, P., Filipetti, P., Duvaldestin, P. Anesthesiology (2001) [Pubmed]
  33. Central motor conduction to upper and lower limbs after magnetic stimulation of the brain and peripheral nerve abnormalities in 20 patients with Friedreich's ataxia. Cruz Martínez, A., Anciones, B. Acta neurologica Scandinavica. (1992) [Pubmed]
  34. Soleus H-reflex gain in humans walking and running under simulated reduced gravity. Ferris, D.P., Aagaard, P., Simonsen, E.B., Farley, C.T., Dyhre-Poulsen, P. J. Physiol. (Lond.) (2001) [Pubmed]
  35. Effects of sleep on spinal nociceptive reflexes in humans. Sandrini, G., Milanov, I., Rossi, B., Murri, L., Alfonsi, E., Moglia, A., Nappi, G. Sleep. (2001) [Pubmed]
  36. Inhibition of canine H reflexes during locomotor-like rotation about the knee arises from muscle mechanoreceptors in quadriceps. Misiaszek, J.E., Barclay, J.K., Brooke, J.D. J. Neurophysiol. (1995) [Pubmed]
  37. The evidence for nitric oxide synthase immunopositivity in the monosynaptic Ia-motoneuron pathway of the dog. Marsala, J., Lukácová, N., Sulla, I., Wohlfahrt, P., Marsala, M. Exp. Neurol. (2005) [Pubmed]
  38. Pentamidine, an inhibitor of spinal flexor reflexes in rats, is a potent N-methyl-D-aspartate (NMDA) antagonist in vivo. Block, F., Schmitt, T., Schwarz, M. Neurosci. Lett. (1993) [Pubmed]
  39. F response and H reflex for monitoring nerve block during epidural analgesia with ropivacaine. Zaric, D., Larsson, P., Axelsson, K., Nydahl, P.A., Philipson, L., Leissner, P. Anesth. Analg. (1994) [Pubmed]
  40. H-reflex latency and nerve root tension sign correlation in fluoroscopically guided, contrast-confirmed, translaminar lumbar epidural steroid-bupivacaine injections. Stretanski, M.F. Archives of physical medicine and rehabilitation. (2004) [Pubmed]
  41. Cervical root compression monitoring by flexor carpi radialis H-reflex in healthy subjects. Sabbahi, M., Abdulwahab, S. Spine. (1999) [Pubmed]
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