The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Aphakia


High impact information on Aphakia

  • These lines of evidence suggest that the abnormal ocular development in the aphakia mouse is due to the deletion upstream of the Pitx3 gene [6].
  • Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19 [7].
  • Therefore, our study provides the first direct evidence that the aphakia allele of Pitx3 is a hypomorph and that Pitx3 is required for the regulation of TH expression in midbrain dopaminergic neurons as well as the generation and/or maintenance of these cells [1].
  • In the aphakia strain, ECM components were observed intercellularly in the presumptive neural retina and lens rudiment of some specimens [8].
  • Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease [9].

Chemical compound and disease context of Aphakia

  • We now show that only a subset of MesDA neurons express Pitx3 and that in Pitx3-deficient aphakia mice, this subset is progressively lost by apoptosis during fetal (substantia nigra, SN) and postnatal (ventral tegmental area) development, resulting in very low striatal DA and akinesia [10].
  • Both polysulfones and hydrogel materials can be used to correct aphakia in clinical situations where other modalities are less appropriate [11].
  • In the 25 patients who received the subconjunctival dose, cefotaxime or its metabolite could be only detected in patients with aphakia or in those who previously underwent vitreal surgery [12].
  • Comparison of fluorine-surface-modified and unmodified lenses for implantation in pediatric aphakia [13].
  • CONCLUSION: Fluorine modification of PMMA IOLs is an effective and safe method to reduce the cicatricial response when IOL implantation is used to correct pediatric aphakia [13].

Biological context of Aphakia


Anatomical context of Aphakia

  • The use of hydrogel lenses could potentially eliminate many of the negative aspects of the use of human donor corneas for the surgical correction of aphakia [17].
  • BACKGROUND: Congenital aphakia is a rare condition that has been classified as primary when no lens induction of the surface ectoderm occurs and secondary when lens development takes place but later is resorbed or expelled in utero [18].

Gene context of Aphakia

  • The mGluR1-signaling downstream-effector phospholipase C beta 4 was identified in a suppression subtractive hybridization screen comparing wild-type and Pit x 3-deficient Aphakia midbrain dopaminergic neurons [19].
  • Keratomileusis for myopia and aphakia [20].
  • Fifty patients with aphakia and strabismus were studied [21].
  • Localization of keratin in the cells of the cornea in aphakia and normal mouse embryos [22].
  • When confronted with pre-existing aphakia (particularly unilateral) the visual and psychological results of secondary Mark VIII implantation are excellent over a wide spectrum of indications and ocular states [23].

Analytical, diagnostic and therapeutic context of Aphakia


  1. Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Maxwell, S.L., Ho, H.Y., Kuehner, E., Zhao, S., Li, M. Dev. Biol. (2005) [Pubmed]
  2. The Teller acuity card procedure. Three testers in a clinical setting. Quinn, G.E., Berlin, J.A., James, M. Ophthalmology (1993) [Pubmed]
  3. Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial. Arcieri, E.S., Santana, A., Rocha, F.N., Guapo, G.L., Costa, V.P. Arch. Ophthalmol. (2005) [Pubmed]
  4. Breakdown of the blood-retinal barriers and cystoid macular edema. Cunha-Vaz, J.G., Travassos, A. Survey of ophthalmology. (1984) [Pubmed]
  5. Combined intraocular lens and strabismus surgery. Maltzman, B.A., Caputo, A.R., Cinotti, D.J. Journal of cataract and refractive surgery. (1986) [Pubmed]
  6. Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice. Semina, E.V., Murray, J.C., Reiter, R., Hrstka, R.F., Graw, J. Hum. Mol. Genet. (2000) [Pubmed]
  7. Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19. Semina, E.V., Reiter, R.S., Murray, J.C. Hum. Mol. Genet. (1997) [Pubmed]
  8. Histochemical analysis of extracellular matrix material during embryonic mouse lens morphogenesis in an aphakic strain of mice. Zwaan, J., Webster, E.H. Dev. Biol. (1984) [Pubmed]
  9. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease. van den Munckhof, P., Gilbert, F., Chamberland, M., Lévesque, D., Drouin, J. J. Neurochem. (2006) [Pubmed]
  10. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. van den Munckhof, P., Luk, K.C., Ste-Marie, L., Montgomery, J., Blanchet, P.J., Sadikot, A.F., Drouin, J. Development (2003) [Pubmed]
  11. Synthetic keratophakia for the correction of aphakia. Werblin, T.P., Peiffer, R.L., Patel, A.S. Ophthalmology (1987) [Pubmed]
  12. The intravitreal penetration of cefotaxime in man following systemic and subconjunctival administrations. Rubinstein, E., Triester, G., Avni, I., Schwartzkopf, R. Ophthalmology (1987) [Pubmed]
  13. Comparison of fluorine-surface-modified and unmodified lenses for implantation in pediatric aphakia. Thouvenin, D., Arne, J.L., Lesueur, L. Journal of cataract and refractive surgery. (1996) [Pubmed]
  14. Corneal ulcers associated with extended-wear soft contact lenses. Weissman, B.A., Mondino, B.J., Pettit, T.H., Hofbauer, J.D. Am. J. Ophthalmol. (1984) [Pubmed]
  15. Hard contact lenses. Medical aspects. O'Riordan, M. Transactions of the ophthalmological societies of the United Kingdom. (1977) [Pubmed]
  16. Juvenile retinal detachment. Winslow, R., Tasman, W.S. International ophthalmology clinics. (1976) [Pubmed]
  17. Hydrogel keratophakia in non-human primates. Binder, P.S., Deg, J.K., Zavala, E.Y., Grossman, K.R. Curr. Eye Res. (1981) [Pubmed]
  18. Congenital aphakia: a clinicopathologic report of three cases. Johnson, B.L., Cheng, K.P. Journal of pediatric ophthalmology and strabismus. (1997) [Pubmed]
  19. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Smits, S.M., van der Nobelen, S., Hornman, K.J., von Oerthel, L., Burbach, J.P., Smidt, M.P. Neuroscience (2005) [Pubmed]
  20. Keratomileusis for myopia and aphakia. Barraquer, J.I. Ophthalmology (1981) [Pubmed]
  21. Strabismus in the aphakic patient. Cohen, R.L., Moore, S. Ophthalmology (1979) [Pubmed]
  22. Localization of keratin in the cells of the cornea in aphakia and normal mouse embryos. Zwaan, J., Webster, E.H. Exp. Eye Res. (1985) [Pubmed]
  23. The Choyce Mark VIII anterior chamber implant: primary and secondary implantation compared. Choyce, D.P. Ophthalmic surgery. (1977) [Pubmed]
  24. Epikeratophakia for aphakia, keratoconus, and myopia. Halliday, B.L. The British journal of ophthalmology. (1990) [Pubmed]
  25. Keratocyte repopulation in epikeratoplasty specimens. Yoon, Y.D., Waring, G.O., Stulting, R.D., Edelhauser, H.F., Grossniklaus, H.E. Cornea (1998) [Pubmed]
  26. Rigid gas-permeable contact lenses are a safe and effective means of treating refractive abnormalities in the pediatric population. Shaughnessy, M.P., Ellis, F.J., Jeffery, A.R., Szczotka, L. The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc. (2001) [Pubmed]
  27. External buckling without drainage. O'Connor, P.R. International ophthalmology clinics. (1976) [Pubmed]
  28. A comparison of grating visual acuity, strabismus, and reoperation outcomes among children with aphakia and pseudophakia after unilateral cataract surgery during the first six months of life. Lambert, S.R., Lynn, M., Drews-Botsch, C., Loupe, D., Plager, D.A., Medow, N.B., Wilson, M.E., Buckley, E.G., Drack, A.V., Fawcett, S.L. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. (2001) [Pubmed]
WikiGenes - Universities