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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Systems Analysis

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Disease relevance of Systems Analysis


High impact information on Systems Analysis

  • To gain insight concerning key intracellular signals governing these behavioral responses, we employ a multivariate systems analysis of proteomic data generated from combinatorial stimulation of mouse embryonic stem cells by fibronectin, laminin, leukemia-inhibitory factor, and fibroblast growth factor 4 [4].
  • Levels of pRB and PCNA expression were quantified using the CAS 200 system (Cell Analysis Systems, Elmhurst, IL) following immunohistochemical staining [5].
  • The fractal dimension may be measured using image analysis systems and the box-counting, divider (perimeter-stepping) and pixel dilation methods have all been described in the published literature [6].
  • The widespread interest in micro total analysis systems has resulted in efforts to develop devices in cheaper polymer materials such as polydimethylsiloxane (PDMS) as an alternative to expensive glass and silicon devices [7].
  • Cross-linked polyacrylamide gel electrophoresis of single-stranded DNA for microfabricated genomic analysis systems [8].

Biological context of Systems Analysis

  • Morphometric analysis using a digital filar micrometer (LaSICO 1602N-10 and 5-4A) measured the mean size of the 10 largest nucleoli, and Feulgen staining and image cytometry (CAS 200 Cell Analysis Systems) analyzed the nuclear DNA ploidy in the lesions [9].
  • After determining intraoperative measurements of serum and ovarian cystic levels of methotrexate, we compared demonstrated pharmacokinetics to those expected by using pharmacokinetic systems analysis software [10].
  • Based on the different analysis systems, we determined the haplotype at the APC locus in 11 at-risk individuals of the three families, six of whom were found to carry the disease-linked allele [11].
  • RESULTS: Behavioral optometry had its origins in strabismus orthoptics and in case analysis systems developed to resolve asthenopic complaints in nonstrabismic individuals [12].
  • In this study, a systems analysis approach was used to study glucose homeostasis which is considered as the dynamic balance between glucose release by the liver and its uptake by the peripheral tissues as regulated by insulin and glucagon [13].

Associations of Systems Analysis with chemical compounds

  • Eight compact analysis systems evaluated for measuring total cholesterol [14].
  • The "Magnesium Liquid Stable Reagent Set" from Medical Analysis Systems, Inc., is evaluated [15].
  • Proliferating cell nuclear antigen (PCNA), a protein associated with DNA polymerase that is expressed only in the nuclei of cells actively synthesizing DNA, was quantitated in 46 formalin-fixed, paraffin-embedded samples of various types of NHL using the Cell Analysis Systems 200 image analyzer [16].
  • Each interview was analysed by three content analysis systems: two computer-supported content analysis of emotional words, the Harvard Third Psychosocial Dictionary and the Martindale Regressive Imagery Dictionary and an observer rating system of utterances emotional depth level, the Cancer Research Campaign Workshop Evaluation Manual [17].
  • Frozen sections immunostained for PgR with a monoclonal antibody (Abbott PgR-ICA, Chicago, IL) and the peroxidase-antiperoxidase technique were scored semiquantitatively histologic score by microscopy and quantitatively (percentage nuclear area immunopositivity [PNA] using the CAS 200 image analyzer (Cell Analysis Systems, Elmhurst, IL) [18].

Gene context of Systems Analysis

  • Then we established three novel quantitative analysis systems for CTGF [19].
  • In this study, the authors investigated whether static cytometric analysis with the CAS 200 Image Analyzer (Cell Analysis Systems, Inc., Elmhurst, IL) with a software program designed for quantitation of nuclear DNA content in tissue sections can be used to classify moles [20].
  • Quality control of proliferation marker (MIB-1) in image analysis systems utilizing cell culture-based control materials [21].
  • For this, C18 cartridges were used because of the strong capacity of this material for the extraction and preconcentration of such vitamins, its ease in handling and the possibility of coupling it with automatic analysis systems [22].
  • Proc Genmod, SAS version 6.14 (Statistical Analysis Systems, Inc, Cary, NC), was used to perform a Wilcoxon test for a nonparametric analysis of covariance and significance adjusted for age and body size [23].

Analytical, diagnostic and therapeutic context of Systems Analysis


  1. Effects of tenotomy surgery on congenital nystagmus waveforms in adult patients. Part II. Dynamical systems analysis. Miura, K., Hertle, R.W., FitzGibbon, E.J., Optican, L.M. Vision Res. (2003) [Pubmed]
  2. Cholesterol in fingerstick capillary specimens can be equivalent to conventional venous measurements. Warnick, G.R., Leary, E.T., Ammirati, E.B., Allen, M.P. Arch. Pathol. Lab. Med. (1994) [Pubmed]
  3. Application of quantitative analysis to biologic profile evaluation in breast cancer. Querzoli, P., Ferretti, S., Albonico, G., Magri, E., Scapoli, D., Indelli, M., Nenci, I. Cancer (1995) [Pubmed]
  4. Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. Prudhomme, W., Daley, G.Q., Zandstra, P., Lauffenburger, D.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Retinoblastoma protein and proliferating-cell nuclear antigen expression as predictors of recurrence in well-differentiated papillary thyroid carcinoma. Omura, K., Nagasato, A., Kanehira, E., Kinsen, H., Amaya, S., Kimura, K., Kajita, T., Nozaki, Y., Mizukami, Y., Nonomura, A., Watanabe, Y. J. Clin. Oncol. (1997) [Pubmed]
  6. Fractals in pathology. Cross, S.S. J. Pathol. (1997) [Pubmed]
  7. Surface characterization using chemical force microscopy and the flow performance of modified polydimethylsiloxane for microfluidic device applications. Wang, B., Abdulali-Kanji, Z., Dodwell, E., Horton, J.H., Oleschuk, R.D. Electrophoresis (2003) [Pubmed]
  8. Cross-linked polyacrylamide gel electrophoresis of single-stranded DNA for microfabricated genomic analysis systems. Ugaz, V.M., Brahmasandra, S.N., Burke, D.T., Burns, M.A. Electrophoresis (2002) [Pubmed]
  9. Histopathology, morphometry, and nuclear DNA content of iris melanocytic lesions. Grossniklaus, H.E., Oakman, J.H., Cohen, C., Calhoun, F.P., DeRose, P.B., Drews-Botsch, C. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  10. Methotrexate sequestration in an ovarian cyst. Jolin, J.A., Hutson, P.R., Schink, J.C. Gynecol. Oncol. (1999) [Pubmed]
  11. The use of DNA markers in the pre-clinical diagnosis of familial adenomatous polyposis. Amikam, D., Niv, D., Lachter, J., Eidelman, S., Ben-Ishai, Z. Isr. J. Med. Sci. (1997) [Pubmed]
  12. Behavioral optometry: a historical perspective. Birnbaum, M.H. Journal of the American Optometric Association. (1994) [Pubmed]
  13. Theoretical analysis of the mechanisms of chronic hyperinsulinemia. Summers, R.L., Montani, J.P., Woodward, L.H., Coleman, T.G., Hall, J.E. Comput. Biol. Med. (1997) [Pubmed]
  14. Eight compact analysis systems evaluated for measuring total cholesterol. Gregory, L.C., Duh, S.H., Christenson, R.H. Clin. Chem. (1994) [Pubmed]
  15. Studies on measurement of plasma magnesium: application of the Magon dye method to the "Monarch" centrifugal analyzer. Barbour, H.M., Davidson, W. Clin. Chem. (1988) [Pubmed]
  16. Proliferative activity in non-Hodgkin's lymphomas. A comparison of the bromodeoxyuridine labeling index with PCNA immunostaining and quantitative image analysis. Sebo, T.J., Roche, P.C., Witzig, T.E., Kurtin, P.J. Am. J. Clin. Pathol. (1993) [Pubmed]
  17. Does training increase the use of more emotionally laden words by nurses when talking with cancer patients? A randomised study. Razavi, D., Delvaux, N., Marchal, S., Durieux, J.F., Farvacques, C., Dubus, L., Hogenraad, R. Br. J. Cancer (2002) [Pubmed]
  18. Immunohistochemical progesterone receptor assay. Measurement by image analysis. el-Badawy, N., Cohen, C., Derose, P.B., Check, I.J., Sgoutas, D. Am. J. Clin. Pathol. (1991) [Pubmed]
  19. Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line. Kawaki, H., Kubota, S., Minato, M., Moritani, N.H., Hattori, T., Hanagata, H., Kubota, M., Miyauchi, A., Nakanishi, T., Takigawa, M. DNA Cell Biol. (2003) [Pubmed]
  20. DNA analysis (ploidy) of molar pregnancies with image analysis on paraffin tissue sections. Barclay, I.D., Dabbagh, L., Babiak, J., Poppema, S. Am. J. Clin. Pathol. (1993) [Pubmed]
  21. Quality control of proliferation marker (MIB-1) in image analysis systems utilizing cell culture-based control materials. Ruby, S.G., McNally, A.C. Am. J. Clin. Pathol. (1996) [Pubmed]
  22. Directly coupled sample treatment-high-performance liquid chromatography for on-line automatic determination of liposoluble vitamins in milk. Delgado-Zamarreño, M.M., Sanchez-Perez, A., Gomez-Perez, M.C., Hernandez-Mendez, J. Journal of chromatography. A. (1995) [Pubmed]
  23. Bone mineral density in grand multiparous women with extended lactation. Henderson, P.H., Sowers, M., Kutzko, K.E., Jannausch, M.L. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  24. Microfabricated PDMS multichannel emitter for electrospray ionization mass spectrometry. Kim, J.S., Knapp, D.R. J. Am. Soc. Mass Spectrom. (2001) [Pubmed]
  25. Results of the multicenter evaluation of the CEDIA Theophylline assay. Klein, G., Castiñeiras, M.J., Collinsworth, W., Courbe, A., Delavenne, M., Hänseler, E., Hannak, D., Kaspar, P., Kattermann, R., Knoke, A. Wiener klinische Wochenschrift. Supplementum. (1992) [Pubmed]
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