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Disease relevance of Thermodilution


High impact information on Thermodilution

  • Arterial and femoral venous blood gas data were obtained and coupled with simultaneous measurements of femoral venous blood flow (Qleg) by thermodilution to obtain O2 delivery and oxygen uptake (VO2) [6].
  • INTERVENTIONS: Invasive hemodynamic measurements were done (using a balloon-tipped thermodilution catheter) before and for 3 hours after a single oral dose of 50 mg of encainide [7].
  • In protocol 1, cardiac output (CO) and stroke volume (SV) were measured by MRI and thermodilution (TD) in 15 mice (3 L1, 4 L2, 8 LC) [8].
  • Central hemodynamic measurements, leg blood flow determined by thermodilution, and systemic and leg metabolic parameters were measured during maximal treadmill exercise before and 2 hours after clonidine 2 micrograms/kg IV (n = 15) or 0.9% normal saline (n = 5) [9].
  • ET-1 and big ET-1 reduced coronary sinus blood flow, measured with thermodilution by a maximum of 25 +/- 4% and 28 +/- 8% and increased coronary vascular resistance by 50 +/- 9% and 107 +/- 26%, respectively [10].

Chemical compound and disease context of Thermodilution


Biological context of Thermodilution


Anatomical context of Thermodilution


Associations of Thermodilution with chemical compounds

  • In 10 of the 13 patients, coronary sinus blood flow was measured by coronary sinus thermodilution technique at rest and after dipyridamole infusion (0.5 mg/kg in 15 minutes) 10 +/- 5 days after quantitative coronary arteriography [23].
  • In 18 patients (13 men and five women, 30 to 76 years old), coronary sinus blood flow (by thermodilution) was measured before and during intracoronary administration of nitroglycerin, 25 micrograms, both before and 5 min after a 15 min intravenous infusion of (1) 5% dextrose in water (n = 8, control) or (2) 100 mg/kg N-acetylcysteine (n = 10) [24].
  • The changes in coronary blood flow in response to intracoronary injection of 3 ml of 76% Renografin were studied in 47 patients using the thermodilution technique for continuous measurement of coronary sinus blood flow [25].
  • To determine whether hydralazine improves O2 transport to working muscle, we examined the effect of intravenous hydralazine on blood flow (measured by thermodilution) and metabolism in the leg during maximal upright bicycle exercise in 10 patients with chronic heart failure [26].
  • LBF was determined by thermodilution: LGU = arteriovenous glucose difference (AVGdelta) x LBF [27].

Gene context of Thermodilution

  • 1. Cardiac index (CI) calculated by the conventional method and thermodilution (TD) showed acceptable correlation (r = 0.90, CITD = 1.20 CIPWD + 357; r = 0.86, CITD = 0.90 CICWD + 262) for pulsed (PWD) and continuous wave (CWD) Doppler, respectively, but with systematic underestimation (-28 +/- 13%, p < 0.01) by pulsed wave Doppler [28].
  • METHODS: We prospectively assessed long-term follow-up and predictors of survival in 62 consecutive patients referred from 1990 to 1992 for evaluation of idiopathic dilated cardiomyopathy, including haemodynamic evaluation, thermodilution right ventricular ejection fraction and volume measurements [29].
  • The Arrow "Hands-Off" thermodilution catheter (AHO) is completely shielded during balloon testing, preparation, and insertion [30].
  • Cardiac output was simultaneously measured by thermodilution to calculate whole body extraction of ANP [31].
  • OBJECTIVE: To evaluate the accuracy and precision of continuous thermodilution (CCO) by using a validated bolus thermodilution (BCO) reference technique as criterion standard [32].

Analytical, diagnostic and therapeutic context of Thermodilution


  1. Acute haemodynamic effects of ibopamine in patients with severe congestive heart failure. Ghirardi, P., Brusoni, B., Mangiavacchi, M., Bianco, L., Col, J., Metra, M., Dei Cas, L. British journal of clinical pharmacology. (1985) [Pubmed]
  2. A comparative evaluation of thermodilution and partial CO2 rebreathing techniques for cardiac output assessment in critically ill patients during assisted ventilation. Rocco, M., Spadetta, G., Morelli, A., Dell'Utri, D., Porzi, P., Conti, G., Pietropaoli, P. Intensive care medicine. (2004) [Pubmed]
  3. Right ventricular volumes determined by computerized thermodilution in ischaemic heart disease: effect of exercise and nitroglycerin. Burger, W., Allroggen, H., Kober, G. International journal of cardiology. (1991) [Pubmed]
  4. Transthoracic bioimpedance can measure extravascular lung water in acute lung injury. Nierman, D.M., Eisen, D.I., Fein, E.D., Hannon, E., Mechanick, J.I., Benjamin, E. J. Surg. Res. (1996) [Pubmed]
  5. A clinical comparative study between crystalloid and blood-based St Thomas' hospital cardioplegic solution. Ibrahim, M.F., Venn, G.E., Young, C.P., Chambers, D.J. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (1999) [Pubmed]
  6. Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure. Marrades, R.M., Roca, J., Campistol, J.M., Diaz, O., Barberá, J.A., Torregrosa, J.V., Masclans, J.R., Cobos, A., Rodríguez-Roisin, R., Wagner, P.D. J. Clin. Invest. (1996) [Pubmed]
  7. Adverse hemodynamic and clinical effects of encainide in severe chronic heart failure. Gottlieb, S.S., Kukin, M.L., Yushak, M., Medina, N., Packer, M. Ann. Intern. Med. (1989) [Pubmed]
  8. Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Franco, F., Thomas, G.D., Giroir, B., Bryant, D., Bullock, M.C., Chwialkowski, M.C., Victor, R.G., Peshock, R.M. Circulation (1999) [Pubmed]
  9. Effect of sympathoinhibition on exercise performance in patients with heart failure. Lang, C.C., Rayos, G.H., Chomsky, D.B., Wood, A.J., Wilson, J.R. Circulation (1997) [Pubmed]
  10. Comparable potent coronary constrictor effects of endothelin-1 and big endothelin-1 in humans. Pernow, J., Kaijser, L., Lundberg, J.M., Ahlborg, G. Circulation (1996) [Pubmed]
  11. Evidence of myocardial ischaemia in patients with chest pain syndromes and normal coronary angiograms. Virtanen, K.S. Acta Med. Scand. Suppl. (1985) [Pubmed]
  12. Type of lung injury influences the thermal-dye estimation of extravascular lung water. Carlile, P.V., Gray, B.A. Journal of applied physiology: respiratory, environmental and exercise physiology. (1984) [Pubmed]
  13. A new method to calculate aortic valve area without left heart catheterization. Warth, D.C., Stewart, W.J., Block, P.C., Weyman, A.E. Circulation (1984) [Pubmed]
  14. Effects of verapamil on left ventricular systolic and diastolic function in patients with hypertrophic cardiomyopathy: pressure-volume analysis with a nonimaging scintillation probe. Bonow, R.O., Ostrow, H.G., Rosing, D.R., Cannon, R.O., Lipson, L.C., Maron, B.J., Kent, K.M., Bacharach, S.L., Green, M.V. Circulation (1983) [Pubmed]
  15. Simple and accurate assessment of forward cardiac output by use of 1-(11)C-acetate PET verified in a pig model. Sörensen, J., Ståhle, E., Långström, B., Frostfeldt, G., Wikström, G., Hedenstierna, G. J. Nucl. Med. (2003) [Pubmed]
  16. Hemodynamic and echocardiographic assessment of the effects of diltiazem during transient occlusion of the left anterior descending coronary artery during percutaneous transluminal coronary angioplasty. Kern, M.J., Pearson, A., Woodruff, R., Deligonul, U., Vandormael, M., Labovitz, A. Am. J. Cardiol. (1989) [Pubmed]
  17. Beta blockers induce different intrarenal effects in humans: demonstration by selective infusion of tertatolol and propranolol. Nitenberg, A., Chemla, D., Blanchet, F., Guery, O., Prost, J.F., Dutray-Dupagne, C. Journal of clinical pharmacology. (1990) [Pubmed]
  18. Contrasting peripheral short-term and long-term effects of converting enzyme inhibition in patients with congestive heart failure. A double-blind, placebo-controlled trial. Drexler, H., Banhardt, U., Meinertz, T., Wollschläger, H., Lehmann, M., Just, H. Circulation (1989) [Pubmed]
  19. Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects. Kingwell, B.A., Formosa, M., Muhlmann, M., Bradley, S.J., McConell, G.K. Diabetes (2002) [Pubmed]
  20. Kinetics of insulin-mediated and non-insulin-mediated glucose uptake in humans. Edelman, S.V., Laakso, M., Wallace, P., Brechtel, G., Olefsky, J.M., Baron, A.D. Diabetes (1990) [Pubmed]
  21. Calf flow reserve with H(2)(15)O PET as a quantifiable index of lower extremity flow. Schmidt, M.A., Chakrabarti, A., Shamim-Uzzaman, Q., Kaciroti, N., Koeppe, R.A., Rajagopalan, S. J. Nucl. Med. (2003) [Pubmed]
  22. Selective infusion of tertatolol into the renal artery induces a local vasodilator effect in humans. Demonstration by the continuous thermodilution method. Nitenberg, A., Prost, J.F., Joussen, J.M., Blanchet, F., Dutray-Dupagne, C. Am. J. Hypertens. (1989) [Pubmed]
  23. Abnormal coronary vasomotion during exercise in patients with normal coronary arteries and reduced coronary flow reserve. Bortone, A.S., Hess, O.M., Eberli, F.R., Nonogi, H., Marolf, A.P., Grimm, J., Krayenbuehl, H.P. Circulation (1989) [Pubmed]
  24. Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine. Winniford, M.D., Kennedy, P.L., Wells, P.J., Hillis, L.D. Circulation (1986) [Pubmed]
  25. The effect of intracoronary injection of contrast medium upon coronary blood flow. Bassan, M., Ganz, W., Marcus, H.S., Swan, H.J. Circulation (1975) [Pubmed]
  26. Effect of hydralazine on perfusion and metabolism in the leg during upright bicycle exercise in patients with heart failure. Wilson, J.R., Martin, J.L., Ferraro, N., Weber, K.T. Circulation (1983) [Pubmed]
  27. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Baron, A.D., Tarshoby, M., Hook, G., Lazaridis, E.N., Cronin, J., Johnson, A., Steinberg, H.O. Diabetes (2000) [Pubmed]
  28. Cardiac index quantification by Doppler ultrasound in patients without left ventricular outflow tract abnormalities. Evangelista, A., Garcia-Dorado, D., Garcia del Castillo, H., Gonzalez-Alujas, T., Soler-Soler, J. J. Am. Coll. Cardiol. (1995) [Pubmed]
  29. Additional predictive value of both left and right ventricular ejection fractions on long-term survival in idiopathic dilated cardiomyopathy. Juillière, Y., Barbier, G., Feldmann, L., Grentzinger, A., Danchin, N., Cherrier, F. Eur. Heart J. (1997) [Pubmed]
  30. The "hands-off" catheter and the prevention of systemic infections associated with pulmonary artery catheter: a prospective study. Cohen, Y., Fosse, J.P., Karoubi, P., Reboul-Marty, J., Dreyfuss, D., Hoang, P., Cupa, M. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  31. Evidence that atrial natriuretic peptide tissue extraction is not changed by large increases in its plasma levels induced by pacing in humans. Iervasi, G., Clerico, A., Pilo, A., Vitek, F., Berti, S., Palmieri, C., Ravani, M., Sabatino, L., Manfredi, C., Del Chicca, M.G., Biagini, A., Donato, L. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  32. Continuous thermodilution cardiac output: clinical validation against a reference technique of known accuracy. Schmid, E.R., Schmidlin, D., Tornic, M., Seifert, B. Intensive care medicine. (1999) [Pubmed]
  33. Cardiopulmonary hemodynamics in systemic sclerosis and response to nifedipine and captopril. Sfikakis, P.P., Kyriakidis, M.K., Vergos, C.G., Vyssoulis, G.P., Psarros, T.K., Kyriakidis, C.A., Mavrikakis, M.E., Sfikakis, P.P., Toutouzas, P.K. Am. J. Med. (1991) [Pubmed]
  34. Relationship between amrinone plasma concentration and cardiac index. Edelson, J., LeJemtel, T.H., Alousi, A.A., Biddlecome, C.E., Maskin, C.S., Sonnenblick, E.H. Clin. Pharmacol. Ther. (1981) [Pubmed]
  35. Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. Maltais, F., Jobin, J., Sullivan, M.J., Bernard, S., Whittom, F., Killian, K.J., Desmeules, M., Bélanger, M., LeBlanc, P. J. Appl. Physiol. (1998) [Pubmed]
  36. Contribution of excising legs to the slow component of oxygen uptake kinetics in humans. Poole, D.C., Schaffartzik, W., Knight, D.R., Derion, T., Kennedy, B., Guy, H.J., Prediletto, R., Wagner, P.D. J. Appl. Physiol. (1991) [Pubmed]
  37. Systemic and pulmonary hemodynamic effects of indapamide in patients with mild arterial hypertension. Magrini, F., Buzzetti, G., De Giovanni, F., Cerati, D., Macchi, G., Mondadori, C. J. Cardiovasc. Pharmacol. (1985) [Pubmed]
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