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Gene Review

Pnlip  -  pancreatic lipase

Mus musculus

Synonyms: 1810007A24Rik, PL, PTL, Pancreatic lipase, Pancreatic triacylglycerol lipase, ...
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Disease relevance of Pnlip


High impact information on Pnlip


Biological context of Pnlip


Anatomical context of Pnlip


Associations of Pnlip with chemical compounds


Other interactions of Pnlip


Analytical, diagnostic and therapeutic context of Pnlip

  • Further dissection of c-Fos C-terminal region showed that the degradation-accelerating effect is not contributed by the whole PEST sequence but by a short PTL tripeptide which cannot be considered as a PEST motif and which can act in the absence of any PEST environment [19].
  • Gel-filtration experiments suggested that EPL did not bind strongly to pancreatic lipase, whereas orlistat did [12].
  • The present study assessed the effects of chitin-chitosan on the activity of pancreatic lipase in vitro and on the degree of fat storage induced in mice by the oral administration of a high-fat diet for nine weeks [20].
  • Our examination of PTL genomic clones isolated from a thirteen-lined ground squirrel genomic DNA library, coupled with genomic Southern blot analysis, enabled us to conclude that PTL mRNAs expressed in heart and WAT are the products of the same single-copy gene [21].


  1. Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. Huggins, K.W., Camarota, L.M., Howles, P.N., Hui, D.Y. J. Biol. Chem. (2003) [Pubmed]
  2. Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Rippe, C., Berger, K., Mei, J., Lowe, M.E., Erlanson-Albertsson, C. Pancreas (2003) [Pubmed]
  3. Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events. Bijvelds, M.J., Bronsveld, I., Havinga, R., Sinaasappel, M., de Jonge, H.R., Verkade, H.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  4. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. Weibel, E.K., Hadvary, P., Hochuli, E., Kupfer, E., Lengsfeld, H. J. Antibiot. (1987) [Pubmed]
  5. Inhibition of pancreatic lipase by poloxamer 407 may provide an adjunct treatment strategy for weight loss. Johnston, T.P., Goldberg, I.J. J. Pharm. Pharmacol. (2006) [Pubmed]
  6. Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Grusby, M.J., Nabavi, N., Wong, H., Dick, R.F., Bluestone, J.A., Schotz, M.C., Glimcher, L.H. Cell (1990) [Pubmed]
  7. Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. Warden, C.H., Davis, R.C., Yoon, M.Y., Hui, D.Y., Svenson, K., Xia, Y.R., Diep, A., He, K.Y., Lusis, A.J. J. Lipid Res. (1993) [Pubmed]
  8. Properties and function of pancreatic lipase related protein 2. Lowe, M.E. Biochimie (2000) [Pubmed]
  9. Inhibitory effects of grape seed extract on lipases. Moreno, D.A., Ilic, N., Poulev, A., Brasaemle, D.L., Fried, S.K., Raskin, I. Nutrition (Burbank, Los Angeles County, Calif.) (2003) [Pubmed]
  10. Acute hemorrhagic pancreatic necrosis in mice. Alterations of pancreatic lipase activity, pancreas lipids, and serum lipoproteins. Rao, K.N., Katyal, S.L., Iammarino, R.M., Lombardi, B. Digestion (1980) [Pubmed]
  11. Metabolism of fenbufen by cultured 3T3-L1 adipocytes: synthesis and metabolism of xenobiotic glycerolipids. Dodds, P.F., Chou, S.C., Ranasinghe, A., Coleman, R.A. J. Lipid Res. (1995) [Pubmed]
  12. Antiobesity action of epsilon-polylysine, a potent inhibitor of pancreatic lipase. Tsujita, T., Takaichi, H., Takaku, T., Aoyama, S., Hiraki, J. J. Lipid Res. (2006) [Pubmed]
  13. Hydrolysis of retinyl esters by pancreatic triglyceride lipase. van Bennekum, A.M., Fisher, E.A., Blaner, W.S., Harrison, E.H. Biochemistry (2000) [Pubmed]
  14. Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout mice. Gilham, D., Labonté, E.D., Rojas, J.C., Jandacek, R.J., Howles, P.N., Hui, D.Y. J. Biol. Chem. (2007) [Pubmed]
  15. Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. Lowe, M.E., Kaplan, M.H., Jackson-Grusby, L., D'Agostino, D., Grusby, M.J. J. Biol. Chem. (1998) [Pubmed]
  16. Combined lipase deficiency (cld/cld) in mice affects differently post-translational processing of lipoprotein lipase, hepatic lipase and pancreatic lipase. Scow, R.O., Schultz, C.J., Park, J.W., Blanchette-Mackie, E.J. Chem. Phys. Lipids (1998) [Pubmed]
  17. Long-term comparative effect of cholecystokinin and gastrin on mouse stomach, antrum, intestine, and exocrine pancreas. Balas, D., Senegas-Balas, F., Pradayrol, L., Vayssette, J., Bertrand, C., Ribet, A. Am. J. Anat. (1985) [Pubmed]
  18. Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice. Lenhard, J.M., Croom, D.K., Weiel, J.E., Spaltenstein, A., Reynolds, D.J., Furfine, E.S. J. Nutr. (2000) [Pubmed]
  19. Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition. Acquaviva, C., Brockly, F., Ferrara, P., Bossis, G., Salvat, C., Jariel-Encontre, I., Piechaczyk, M. Oncogene (2001) [Pubmed]
  20. Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Han, L.K., Kimura, Y., Okuda, H. Int. J. Obes. Relat. Metab. Disord. (1999) [Pubmed]
  21. Pancreatic triacylglycerol lipase in a hibernating mammal. I. Novel genomic organization. Squire, T.L., Andrews, M.T. Physiol. Genomics (2003) [Pubmed]
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