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MeSH Review

Bronchiolitis Obliterans Organizing Pneumonia

 
 
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Disease relevance of Bronchiolitis Obliterans Organizing Pneumonia

 

High impact information on Bronchiolitis Obliterans Organizing Pneumonia

  • It was shown with two different VEGF antibodies that its expression was more pronounced in the intraluminal fibromyxoid lesions in BOOP than in UIP (p<0.001 and 0.004, respectively) [6].
  • Similarly, bFGF also showed stronger espression in BOOP than in UIP (p<0.02) in these areas [6].
  • The results show that both VEGF and bFGF are widely expressed in BOOP and in UIP [6].
  • IPF-UIP cases showed predominant expression of MMP-9, whereas NSIP and BOOP cases showed predominant MMP-2 expression in BALF and in tissues [7].
  • We conclude that PDGF+ cells and CD68+ macrophages are found in greater numbers in lungs with BOOP, and an increased expression of PDGFR-beta epitopes was observed in some patients with BOOP [8].
 

Chemical compound and disease context of Bronchiolitis Obliterans Organizing Pneumonia

  • We report a case of BOOP after OLT to highlight the risk in all transplant patients as well as the protective effect of posttransplant prednisone [9].
  • BOOP associated with nitrofurantoin [10].
  • In this study, we examined matched groups of 10 patients with steroid-responsive idiopathic BOOP/COP and 9 patients with idiopathic BOOP/COP who fared poorly despite therapy [11].
  • Complete remission of BOOP was achieved by long-term treatment with low-dose methotrexate (5-20 mg/week, i.v.) [12].
  • BALF from all patients was obtained before prednisolone therapy. sFasL levels were relatively increased in IPF patients (p = 0.084), and significantly increased in CVD-IP patients (p < 0.05) and BOOP patients (p < 0.05), compared with control subjects [13].
 

Anatomical context of Bronchiolitis Obliterans Organizing Pneumonia

  • In patients with IPF, IP-SSc, and idiopathic BOOP, the TF antigen was positively stained in type II pneumocytes and in some alveolar macrophages [14].
  • PDGFR-beta immunoreactivity was present in some alveolar epithelial cells in BOOP, but was absent in control subjects [8].
  • Serial sections of lung biopsy specimens from 20 patients with BOOP and 10 control subjects were stained with antibodies against PDGF, PDGFR-beta, and the monocyte/macrophage marker CD68 [8].
  • It is concluded that the growth factors VEGF and bFGF may have an important role in the pathogenesis of BOOP and UIP; furthermore, their expression correlates with the angiogenic activity of the newly formed intraluminal fibromyxoid connective tissue in BOOP [6].
  • To determine whether mast cells are implicated in the pathogenesis of BOOP, mast cells were identified in BAL fluid and in transbronchial lung biopsy specimens from 11 patients affected by BOOP and 17 control subjects [15].
 

Gene context of Bronchiolitis Obliterans Organizing Pneumonia

  • Western blotting showed the existence of a latent form of MMP-9 and latent and active forms of MMP-2, and gelatin zymography revealed that the ratio of active/latent forms of MMP-2 in BOOP is significantly larger than that in the control lungs [3].
  • The changes in ECM and the localization of matrix metalloproteinases (MMPs) and a tissue inhibitor of metalloproteinases (TIMP) in the lung tissues of patients with bronchiolitis obliterans organizing pneumonia (BOOP) and idiopathic pulmonary fibrosis (IPF) were investigated [3].
  • In addition, BALf levels of IL10, an anti-inflammatory cytokine, were significantly higher in BOOP patients with respect to controls and UIP patients [16].
  • These results indicate that MMP-9 in IPF-UIP and MMP-2 in NSIP and BOOP may contribute to pulmonary structural remodeling through type IV collagenolytic activity [7].
  • In this study, we stained diagnostic thoracoscopic or open lung biopsy specimens of patients with BOOP (n = 9) and UIP (n = 10) with antibodies against human laminin, von Willebrand factor, and CD34 to reveal the microvasculature of intraluminal fibromyxoid lesions [4].
 

Analytical, diagnostic and therapeutic context of Bronchiolitis Obliterans Organizing Pneumonia

References

  1. Risedronate induced BOOP complicated with sarcoidosis. Arai, T., Inoue, Y., Hayashi, S., Yamamoto, S., Sakatani, M. Thorax (2005) [Pubmed]
  2. Pulmonary involvement in rheumatoid arthritis. Anaya, J.M., Diethelm, L., Ortiz, L.A., Gutierrez, M., Citera, G., Welsh, R.A., Espinoza, L.R. Semin. Arthritis Rheum. (1995) [Pubmed]
  3. Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. Fukuda, Y., Ishizaki, M., Kudoh, S., Kitaichi, M., Yamanaka, N. Lab. Invest. (1998) [Pubmed]
  4. Intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia are highly capillarized. Lappi-Blanco, E., Kaarteenaho-Wiik, R., Soini, Y., Risteli, J., Pääkkö, P. Hum. Pathol. (1999) [Pubmed]
  5. B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary fibrosis and bronchiolitis obliterans-organizing pneumonia. Kaneko, Y., Kuwano, K., Kunitake, R., Kawasaki, M., Hagimoto, N., Hara, N. Eur. Respir. J. (2000) [Pubmed]
  6. VEGF and bFGF are highly expressed in intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia. Lappi-Blanco, E., Soini, Y., Kinnula, V., Pääkkö, P. J. Pathol. (2002) [Pubmed]
  7. Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias. Suga, M., Iyonaga, K., Okamoto, T., Gushima, Y., Miyakawa, H., Akaike, T., Ando, M. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  8. Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. Aubert, J.D., Paré, P.D., Hogg, J.C., Hayashi, S. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  9. Bronchiolitis obliterans organizing pneumonia in an orthotopic liver transplant patient. DeAngelo, A.J., Ouellette, D. Transplantation (2002) [Pubmed]
  10. BOOP associated with nitrofurantoin. Fawcett, I.W., Ibrahim, N.B. Thorax (2001) [Pubmed]
  11. Idiopathic bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors. Yousem, S.A., Lohr, R.H., Colby, T.V. Mod. Pathol. (1997) [Pubmed]
  12. Successful treatment of bronchiolitis obliterans organizing pneumonia with low-dose methotrexate in a patient with Hodgkin's disease. Egerer, G., Witzens, M., Spaeth, A., Breitbart, A., Möller, P., Goldschmidt, H., Ho, A.D. Oncology (2001) [Pubmed]
  13. Soluble form of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia. Kuwano, K., Kawasaki, M., Maeyama, T., Hagimoto, N., Nakamura, N., Shirakawa, K., Hara, N. Chest (2000) [Pubmed]
  14. Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. Imokawa, S., Sato, A., Hayakawa, H., Kotani, M., Urano, T., Takada, A. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  15. Mast cells in bronchiolitis obliterans organizing pneumonia. Mast cell hyperplasia and evidence for extracellular release of tryptase. Pesci, A., Majori, M., Piccoli, M.L., Casalini, A., Curti, A., Franchini, D., Gabrielli, M. Chest (1996) [Pubmed]
  16. Cytokine profile of broncho-alveolar lavage in BOOP and UIP. Forlani, S., Ratta, L., Bulgheroni, A., Cascina, A., Paschetto, E., Cervio, G., Luinetti, O., Fietta, A.M., Meloni, F. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (2002) [Pubmed]
  17. Improvement in bronchiolitis obliterans organizing pneumonia in a child after allogeneic bone marrow transplantation by a combination of oral prednisolone and low dose erythromycin. Ishii, T., Manabe, A., Ebihara, Y., Ueda, T., Yoshino, H., Mitsui, T., Hisakawa, H., Yagasaki, H., Kikuchi, A., Yoshimasu, T., Tanaka, R., Takahashi, T., Masunaga, A., Sugita, K.I., Nakahata, T., Asano, S., Tsuji, K. Bone Marrow Transplant. (2000) [Pubmed]
  18. Bronchiolitis obliterans organizing pneumonia following chlorambucil treatment for chronic lymphocytic leukemia. Kalambokis, G., Stefanou, D., Arkoumani, E., Tsianos, E. Eur. J. Haematol. (2004) [Pubmed]
  19. Oleic acid-associated bronchiolitis obliterans-organizing pneumonia in beagle dogs. Li, X., Botts, S., Morton, D., Knickerbocker, M.J., Adler, R. Vet. Pathol. (2006) [Pubmed]
  20. Increased macrophage inflammatory protein-1alpha and -1beta in BAL fluid of bronchiolitis obliterans organizing pneumonia. Asano, T., Ogushi, F., Tani, K., Tamiya, H., Nishioka, Y., Sone, S. Respirology (2003) [Pubmed]
  21. Bronchiolitis obliterans organizing pneumonia: a late complication of stem cell transplantation. Moore, S.L. Clinical journal of oncology nursing. (2003) [Pubmed]
 
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