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Gene Review

RXRA  -  retinoid X receptor, alpha

Homo sapiens

Synonyms: NR2B1, Nuclear receptor subfamily 2 group B member 1, Retinoic acid receptor RXR-alpha, Retinoid X receptor alpha
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Disease relevance of RXRA


High impact information on RXRA


Chemical compound and disease context of RXRA


Biological context of RXRA


Anatomical context of RXRA


Associations of RXRA with chemical compounds


Physical interactions of RXRA


Enzymatic interactions of RXRA


Co-localisations of RXRA


Regulatory relationships of RXRA


Other interactions of RXRA


Analytical, diagnostic and therapeutic context of RXRA


  1. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Tontonoz, P., Singer, S., Forman, B.M., Sarraf, P., Fletcher, J.A., Fletcher, C.D., Brun, R.P., Mueller, E., Altiok, S., Oppenheim, H., Evans, R.M., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. Li, Y., Hashimoto, Y., Agadir, A., Kagechika, H., Zhang, X. J. Biol. Chem. (1999) [Pubmed]
  3. Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha. Ishimoto, K., Tachibana, K., Sumitomo, M., Omote, S., Hanano, I., Yamasaki, D., Watanabe, Y., Tanaka, T., Hamakubo, T., Sakai, J., Kodama, T., Doi, T. FEBS Lett. (2006) [Pubmed]
  4. Positive and negative regulations of albumin gene expression by retinoids in human hepatoma cell lines. Yamada, Y., Shidoji, Y., Fukutomi, Y., Ishikawa, T., Kaneko, T., Nakagama, H., Imawari, M., Moriwaki, H., Muto, Y. Mol. Carcinog. (1994) [Pubmed]
  5. Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. Tsujie, M., Nakamori, S., Okami, J., Takahashi, Y., Hayashi, N., Nagano, H., Dono, K., Umeshita, K., Sakon, M., Monden, M. Int. J. Oncol. (2003) [Pubmed]
  6. Accumulation of retinoid X receptor-alpha in uterine leiomyomas is associated with a delayed ligand-dependent proteasome-mediated degradation and an alteration of its transcriptional activity. Lattuada, D., Viganó, P., Mangioni, S., Sassone, J., Di Francesco, S., Vignali, M., Di Blasio, A.M. Mol. Endocrinol. (2007) [Pubmed]
  7. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Collins, J.L., Moore, L.B., Willson, T.M., Moore, J.T. Mol. Cell (2004) [Pubmed]
  8. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. Mann, K.K., Padovani, A.M., Guo, Q., Colosimo, A.L., Lee, H.Y., Kurie, J.M., Miller, W.H. J. Clin. Invest. (2005) [Pubmed]
  9. Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. Tsujie, M., Nakamori, S., Okami, J., Hayashi, N., Hiraoka, N., Nagano, H., Dono, K., Umeshita, K., Sakon, M., Monden, M. Exp. Cell Res. (2003) [Pubmed]
  10. Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells. Wu, Q., Lin, X.F., Ye, X.F., Zhang, B., Xie, Z., Su, W.J. J. Mol. Endocrinol. (2004) [Pubmed]
  11. Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34. Jones, K.A., Fitzgibbon, J., Woodward, K.J., Goudie, D., Ferguson-Smith, M.A., Povey, S., Wolfe, J., Solomon, E. Ann. Hum. Genet. (1993) [Pubmed]
  12. RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. Bugge, T.H., Pohl, J., Lonnoy, O., Stunnenberg, H.G. EMBO J. (1992) [Pubmed]
  13. Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5. Dwivedi, P.P., Hii, C.S., Ferrante, A., Tan, J., Der, C.J., Omdahl, J.L., Morris, H.A., May, B.K. J. Biol. Chem. (2002) [Pubmed]
  14. Acceleration of thrombomodulin gene transcription by retinoic acid: retinoic acid receptors and Sp1 regulate the promoter activity through interactions with two different sequences in the 5'-flanking region of human gene. Horie, S., Ishii, H., Matsumoto, F., Kusano, M., Kizaki, K., Matsuda, J., Kazama, M. J. Biol. Chem. (2001) [Pubmed]
  15. Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. Noreault, T.L., Kostrubsky, V.E., Wood, S.G., Nichols, R.C., Strom, S.C., Trask, H.W., Wrighton, S.A., Evans, R.M., Jacobs, J.M., Sinclair, P.R., Sinclair, J.F. Drug Metab. Dispos. (2005) [Pubmed]
  16. Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes. Boudjelal, M., Wang, Z., Voorhees, J.J., Fisher, G.J. Cancer Res. (2000) [Pubmed]
  17. Accumulation of RXR alpha during activation of cycling human T lymphocytes: modulation of RXRE transactivation function by mitogen-activated protein kinase pathways. Ishaq, M., Fan, M., Natarajan, V. J. Immunol. (2000) [Pubmed]
  18. The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity. Takano, Y., Adachi, S., Okuno, M., Muto, Y., Yoshioka, T., Matsushima-Nishiwaki, R., Tsurumi, H., Ito, K., Friedman, S.L., Moriwaki, H., Kojima, S., Okano, Y. J. Biol. Chem. (2004) [Pubmed]
  19. Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Goodwin, B., Moore, L.B., Stoltz, C.M., McKee, D.D., Kliewer, S.A. Mol. Pharmacol. (2001) [Pubmed]
  20. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Auerbach, S.S., Stoner, M.A., Su, S., Omiecinski, C.J. Mol. Pharmacol. (2005) [Pubmed]
  21. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Pascussi, J.M., Drocourt, L., Fabre, J.M., Maurel, P., Vilarem, M.J. Mol. Pharmacol. (2000) [Pubmed]
  22. Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands. Macoritto, M., Nguyen-Yamamoto, L., Huang, D.C., Samuel, S., Yang, X.F., Wang, T.T., White, J.H., Kremer, R. J. Biol. Chem. (2008) [Pubmed]
  23. Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Lu, D., Cottam, H.B., Corr, M., Carson, D.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  24. 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. Singh, R.R., Gururaj, A.E., Vadlamudi, R.K., Kumar, R. J. Biol. Chem. (2006) [Pubmed]
  25. Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. Lengqvist, J., Mata de Urquiza, A., Perlmann, T., Sjövall, J., Griffiths, W.J. Journal of mass spectrometry : JMS. (2005) [Pubmed]
  26. Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. Solomon, C., White, J.H., Kremer, R. J. Clin. Invest. (1999) [Pubmed]
  27. MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth. Zhang, S., He, Q., Peng, H., Tedeschi-Blok, N., Triche, T.J., Wu, L. Cancer Res. (2004) [Pubmed]
  28. 9-Cis retinoic acid inhibits growth of breast cancer cells and down-regulates estrogen receptor RNA and protein. Rubin, M., Fenig, E., Rosenauer, A., Menendez-Botet, C., Achkar, C., Bentel, J.M., Yahalom, J., Mendelsohn, J., Miller, W.H. Cancer Res. (1994) [Pubmed]
  29. Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity. Salbert, G., Fanjul, A., Piedrafita, F.J., Lu, X.P., Kim, S.J., Tran, P., Pfahl, M. Mol. Endocrinol. (1993) [Pubmed]
  30. A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha. Claret, F.X., Antakly, T., Karin, M., Saatcioglu, F. Mol. Cell. Biol. (1996) [Pubmed]
  31. Replication of the wild type and a natural hepatitis B virus nucleocapsid promoter variant is differentially regulated by nuclear hormone receptors in cell culture. Tang, H., Raney, A.K., McLachlan, A. J. Virol. (2001) [Pubmed]
  32. Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Kwon, H.S., Huang, B., Ho Jeoung, N., Wu, P., Steussy, C.N., Harris, R.A. Biochim. Biophys. Acta (2006) [Pubmed]
  33. Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha. Miyata, K.S., McCaw, S.E., Meertens, L.M., Patel, H.V., Rachubinski, R.A., Capone, J.P. Mol. Cell. Endocrinol. (1998) [Pubmed]
  34. RXRA and HSPA5 map to the telomeric end of dog chromosome 9. Werner, P., Raducha, M.G., Prociuk, U., Lyons, L.A., Kehler, J.S., Henthorn, P.S., Patterson, D.F. Anim. Genet. (1998) [Pubmed]
  35. A 5'-distal element mediates vitamin D-inducibility of PDGF-A gene transcription. Pedigo, N., Zhang, H., Koszewski, N.J., Kaetzel, D.M. Growth Factors (2003) [Pubmed]
  36. Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Sérée, E., Villard, P.H., Pascussi, J.M., Pineau, T., Maurel, P., Nguyen, Q.B., Fallone, F., Martin, P.M., Champion, S., Lacarelle, B., Savouret, J.F., Barra, Y. Gastroenterology (2004) [Pubmed]
  37. The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. Yamaguchi, K., Groopman, J.E., Byrn, R.A. AIDS (1994) [Pubmed]
  38. Decreased retinoid X receptor-alpha protein expression in basal cells occurs in the early stage of human prostate cancer development. Mao, G.E., Reuter, V.E., Cordon-Cardo, C., Dalbagni, G., Scher, H.I., DeKernion, J.B., Zhang, Z.F., Rao, J. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
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