Disease relevance of methocarbamol

• Intravenous methocarbamol in the treatment of stiff-man syndrome [1].
• A double-blind trial of methocarbamol versus placebo in painful muscle spasm [2].
• Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals [3].
• Therapeutic trial of methocarbamol (Robinax) in tetanus neonatorum [4].

Psychiatry related information on methocarbamol

• The effects of orally administered placebo, diphenhydramine, lorazepam, methocarbamol and placebo were studied in volunteers with histories of recreational substance abuse including sedative/hypnotics [5].

High impact information on methocarbamol

• Northern blot and in situ hybridization revealed neuraxin mRNA to be expressed throughout the rodent central nervous system (CNS) [6].
• The gene encoding neuraxin appears to be unique in the haploid rat genome and conserved in higher vertebrates [6].
• Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5 [6].
• Codanin-1 has a 150-residue amino-terminal domain with sequence similarity to collagens and two shorter segments that show weak similarities to the microtubule-associated proteins, MAP1B (neuraxin) and synapsin [7].
• CA I appeared to bind carbamate esters more tightly than CA II, an unusual 1000-fold selectivity being seen in the case of methocarbamol [8].

Biological context of methocarbamol

• From cloned DNA, neuraxin has been identified as a tubulin binding protein of predicted molecular weight of 94 kDa [9].
• These data are consistent with neuraxin corresponding to a C-terminal fragment of MAP5 that contains a low-affinity tubulin binding site [9].
• The assay was used to study the pharmacokinetics of methocarbamol enantiomers in a rat following intravenous administration of a 120 mg/kg dose of racemic methocarbamol and to evaluate plasma and urine concentrations in a human volunteer after oral administration of a 1000-mg dose of the racemate [10].
• Analysis of the concentration-time profiles reveals that base-catalyzed methocarbamol hydrolysis proceeded mainly through the formation of its isomer [11].
• The kinetics of the hydrolysis of methocarbamol to the corresponding diol guaifenesin in aqueous solution was studied [11].

Anatomical context of methocarbamol

• Parafon Forte versus Robaxisal in skeletal muscle disorders: a double-blind study [12].

Associations of methocarbamol with other chemical compounds

• Placebo, diphenhydramine (100, 200 and 400 mg), lorazepam (1 and 4 mg) and methocarbamol (2.25 and 9 g) were tested in a randomized, double-blind crossover study using 14 subjects [5].
• A comparison of calcium gluconate and methocarbamol (Robaxin) in the treatment of Latrodectism (black widow spider envenomation) [13].
• The rotarod test was used to compare the muscle relaxant activity of racemic methocarbamol and pure enantiomers after intraperitoneal administration of the enantiomers to mice [14].
• The application of the ratio spectra derivative spectrophotometry and high-performance liquid chromatography (HPLC) to the simultaneous determination of paracetamol (PAR) and methocarbamol (MET) in combined pharmaceutical tablets is presented [15].
• In contrast to other published series, the postoperative analgesia after MIRPE in this series consisted of narcotics, ketorolac, and methocarbamol [16].

Gene context of methocarbamol

• Serum haptoglobin levels fell after both high-dose methocarbamol and vehicle during the 3-day period of treatment [17].
• Here, we show that different neuraxin antibodies recognize MAP5, but fail to detect a protein of 94 kDa, in subcellular and microtubular fractions of the rat central nervous system [9].

Analytical, diagnostic and therapeutic context of methocarbamol

• Sequence analysis identified a novel type of neuron-specific protein (named neuraxin) which is characterized by an unusual amino acid composition, 12 central heptadecarepeats and putative protein and/or membrane interaction sites [6].
• Significant increases in plasma hemoglobin were detected 30 min after intravenous injection of methocarbamol or its vehicle alone [17].
• A new HPLC technique for the separation of methocarbamol enantiomers [18].
• We have developed a stereoselective high-performance liquid chromatography technique for analytical separation of methocarbamol enantiomers [18].
• 1. Permethylation and g.l.c.-mass spectrometric analysis of bile from an isolated rat liver perfusion to which methocarmol was added showed seven components not present in control bile: methocarbamol, glucuronides of methocarbamol and desmethyl-methocarbamol, and four glucuronides of hydroxylated methocarbamol metabolites [19].

References