High impact information on Pacinian Corpuscles

• Pacinian corpuscles sited in the hindfeet of intoxicated cats were much less vulnerable to MBK than to acrylamide [1].
• AR was found located also in the flat fibroblast-like cells of Pacinian corpuscles [2].
• 1. Single axons innervating Pacinian corpuscles and rapidly adapting mechanoreceptors of the foot and toe pads were injected with horseradish peroxidase near their entrance to the lumbosacral spinal cord in cats anaesthetized with chloralose and paralysed with gallamine triethiodide [3].
• Thus, Pacinian corpuscles do not form, and their afferents do not survive, in the absence of ER81 [4].
• Our results suggest that multiple neurotrophins, in particular NT3, regulate the density of crural Pacinian corpuscles, most likely by regulating the survival of sensory neurons [5].

Anatomical context of Pacinian Corpuscles

• Small-diameter nerve fibers further expressed alpha 1, alpha 2, and alpha v. Meissner's corpuscles and inner cores of Pacinian corpuscles shared the integrin repertoire of small-diameter nerve fibers with additional expression of alpha 3; outer cores of Pacinian corpuscles were beta 1+, alpha 3+, alpha 6+, and beta 4+ [6].
• In the fetus, autonomic ganglia occur in association with noradrenaline rich paraganglia and surprisingly, with sensory nerve endings resembling pacinian corpuscles [7].
• Other intermediate filament proteins such as vimentin are localized in the lamellar cells of Meissner corpuscles, and in the inner core, outer core and capsule of Pacinian corpuscles [8].
• Light microscope immunohistochemistry showed beta APP immunoreactivity (IR) in: (a) dermal nerves; (b) lamellar cells of Meissner, as well as inner-core, outer-core and capsule of Pacinian corpuscles; and (c) dermal blood vessels, sweat glands and, occasionally, epidermis [9].
• The results suggest that the extracellular matrix of rat Pacinian corpuscles may contain molecules that are produced by Schwann cells and fibroblasts during maturation of the multilamellar auxiliary structures [10].

Associations of Pacinian Corpuscles with chemical compounds

• Intensity and frequency characteristics of pacinian corpuscles. I. Action potentials [11].
• Pacinian corpuscles in rats with carbon disulphide neuropathy [12].
• Effect of morphine and leucine-enkephalin on the electrophysiological responses of Pacinian corpuscles of the cat [13].
• Depression with 240-Hz stimulation was attenuated by administration of caffeine (60 mg/kg i.v.) suggesting that the depressant and biphasic-1 responses may be mediated by afferents from Pacinian corpuscles [14].
• The interosseal Pacinian corpuscles of the rat were fixed either in 2% formaldehyde and 1.5% glutaraldehyde, with the addition of one of these cationic dyes or, in Zamboni's fixative, with tannic acid added [15].

Gene context of Pacinian Corpuscles

• In the pacinian corpuscles, S100P IR was restricted to the inner-core cells whereas CB and PV IR were found labelling the axon, inner core, outer core and capsule [16].
• Regarding Pacinian corpuscles, the mutation in the trkB gene does not alter either the immunohistochemical or the ultrastructural characteristics [17].
• TGF-beta1, 2 and Smad 4 were also observed in inner core lamellar cells of intact and denervated cat Pacinian corpuscles [18].
• Immunocytochemical demonstration of protein kinase C (PKC) subspecies (alpha, beta, gamma) was carried out in Pacinian corpuscles of rat hind feet using monoclonal or polyclonal antibodies against each of these subspecies [19].
• Meissner's and Pacinian corpuscles as studied by immunohistochemistry for S-100 protein, neuron-specific enolase and neurofilament protein [20].

Analytical, diagnostic and therapeutic context of Pacinian Corpuscles

• Perineurial-derived lamellar cells of Pacinian corpuscles exhibited a strong Glut-1-like immunoreactivity in response to denervation and during development [21].

References