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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Postprandial Period

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Disease relevance of Postprandial Period


High impact information on Postprandial Period

  • CONCLUSIONS--Recommended over-the-counter doses of famotidine and calcium carbonate tablets have different pharmacokinetic profiles when taken in the postprandial period [3].
  • METHODS: LES pressure, esophageal pressures, esophageal pH, and crural diaphragm electromyogram were recorded simultaneously in the postprandial period for 30 minutes before and two 30-minute periods after the injection of atropine [4].
  • BACKGROUND & AIMS: EM523, a motilin agonist, is intended to be used as a gastroprokinetic during the postprandial period, but the mechanism(s) by which EM523 stimulates postprandial contractions in the stomach has not been studied before [5].
  • Our data suggest that individuals who ingest moderate amounts of caffeine may develop hypoglycemic symptoms if plasma glucose levels fall into the "low-normal" range, as might occur in the late postprandial period after ingestion of a large carbohydrate load [6].
  • We hypothesized that postprandial glycemic excursions could be normalized in type 1 diabetes by suppressing glucagon with pramlintide acetate in the immediate postprandial period and supplementing glucagon in the late postprandial period [7].

Biological context of Postprandial Period


Anatomical context of Postprandial Period


Associations of Postprandial Period with chemical compounds

  • Concomitant administration of caffeine (250 mg, 30 minutes before breakfast), however, maintained the beneficial effect of dihydroergotamine during the postprandial period [18].
  • CR did not differ significantly when values in the fasting state were compared with those in the postprandial periods and was therefore unaffected by plasma C-peptide concentration [19].
  • In the dosis used cisapride was found to increase lower oesophageal sphincter pressure in the interdigestive and in the late postprandial state, but to have no effect in the early postprandial period [20].
  • Vitamin A was added to the test meal in all subjects to trace the metabolism of the chylomicron (Sf greater than 1000) and non-chylomicron (Sf less than 1000) fractions in the postprandial period [21].
  • RESULTS: During the four hour postprandial period, 5-HT concentrations were significantly higher in patients with IBS than in healthy volunteers at 0.5 hours (p < 0.05), 2 hours (p < 0.05) and 2.5 hours (p < 0.05) [22].

Gene context of Postprandial Period

  • Furthermore, in type IIB subjects, CETP-mediated total CE flux over the 8 h postprandial period from HDL to potentially atherogenic TRL was significantly enhanced, and notably to VLDL-1 (32-fold elevation; P < 0.005), relative to control subjects [23].
  • Furthermore, there was a positive correlation between changes in EGG-3 cpm amplitude and those in serum immunoreactive hPP levels during the postprandial periods (r = 0.55, p < 0.001) [24].
  • Circulating levels of glucose, insulin, glucagon, glucose insulinotrophic peptide (GIP) and GLP-1 were measured over a 9-h postprandial period [25].
  • It is concluded that in dumpers pancreatic glucagon is augmented in the early postprandial period, probably through stimulation by catecholamines [26].
  • Our study demonstrates that, during the postprandial period, motilin antral receptors can be stimulated only with doses of motilin exceeding the physiological plasma concentrations, and that the motor effect obtained did not mimic the usual postprandial motility pattern [27].

Analytical, diagnostic and therapeutic context of Postprandial Period


  1. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.P., Colette, C. JAMA (2006) [Pubmed]
  2. Diagnostic value of serum bile acids. Javitt, N.B. Clinics in gastroenterology. (1977) [Pubmed]
  3. Comparison of the effects of over-the-counter famotidine and calcium carbonate antacid on postprandial gastric acid. A randomized controlled trial. Feldman, M. JAMA (1996) [Pubmed]
  4. Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects. Mittal, R.K., Holloway, R., Dent, J. Gastroenterology (1995) [Pubmed]
  5. Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs. Shiba, Y., Mizumoto, A., Inatomi, N., Haga, N., Yamamoto, O., Itoh, Z. Gastroenterology (1995) [Pubmed]
  6. Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Kerr, D., Sherwin, R.S., Pavalkis, F., Fayad, P.B., Sikorski, L., Rife, F., Tamborlane, W.V., During, M.J. Ann. Intern. Med. (1993) [Pubmed]
  7. The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes. Heptulla, R.A., Rodriguez, L.M., Bomgaars, L., Haymond, M.W. Diabetes (2005) [Pubmed]
  8. Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes. Ceriello, A., Piconi, L., Quagliaro, L., Wang, Y., Schnabel, C.A., Ruggles, J.A., Gloster, M.A., Maggs, D.G., Weyer, C. Diabetes Care (2005) [Pubmed]
  9. Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy. al-Shoumer, K.A., Cox, K.H., Hughes, C.L., Richmond, W., Johnston, D.G. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  10. Pramlintide for the treatment of insulin-requiring diabetes mellitus: rationale and review of clinical data. Kruger, D.F., Gloster, M.A. Drugs (2004) [Pubmed]
  11. Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period. Saleh, J., Summers, L.K., Cianflone, K., Fielding, B.A., Sniderman, A.D., Frayn, K.N. J. Lipid Res. (1998) [Pubmed]
  12. Postprandial sympatho-adrenal activity: its relation to metabolic and cardiovascular events and to changes in meal frequency. Vaz, M., Turner, A., Kingwell, B., Chin, J., Koff, E., Cox, H., Jennings, G., Esler, M. Clin. Sci. (1995) [Pubmed]
  13. Postprandial plasma concentrations of glycine and taurine conjugated bile acids in healthy subjects. Linnet, K. Gut (1983) [Pubmed]
  14. Ethanol suppresses smooth muscle cell proliferation in the postprandial state: a new antiatherosclerotic mechanism of ethanol? Locher, R., Suter, P.M., Vetter, W. Am. J. Clin. Nutr. (1998) [Pubmed]
  15. Leucine excess under conditions of low or compensated aminoacidemia does not change skeletal muscle and whole-body protein synthesis in suckling lambs during postprandial period. Papet, I., Glomot, F., Grizard, J., Arnal, M. J. Nutr. (1992) [Pubmed]
  16. Tegaserod does not alter fasting or meal-induced biliary tract motility. Fisher, R.S., Thistle, J., Lembo, A., Novick, J., O'Kane, P., Chey, W.D., Beglinger, C., Rueegg, P., Shi, V., Dogra, A., Luo, D., Earnest, D.L. Am. J. Gastroenterol. (2004) [Pubmed]
  17. Investigation of drug absorption from the gastrointestinal tract of man. V. Effect of the beta-adrenoceptor antagonist, metoprolol, on postprandial gastric function. Jobin, G., Cortot, A., Danquechin-Dorval, E., Godbillon, J., Schoeller, J.P., Bernier, J.J., Hirtz, J. British journal of clinical pharmacology. (1985) [Pubmed]
  18. Treatment of orthostatic hypotension with dihydroergotamine and caffeine. Hoeldtke, R.D., Cavanaugh, S.T., Hughes, J.D., Polansky, M. Ann. Intern. Med. (1986) [Pubmed]
  19. Estimation of the secretion rate of insulin from the urinary excretion rate of C-peptide. Study in obese and diabetic subjects. Meistas, M.T., Rendell, M., Margolis, S., Kowarski, A.A. Diabetes (1982) [Pubmed]
  20. Effects of cisapride, a new gastrointestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man. Smout, A.J., Bogaard, J.W., Grade, A.C., ten Thije, O.J., Akkermans, L.M., Wittebol, P. Gut (1985) [Pubmed]
  21. Postprandial triglyceride response in type 1 (insulin-dependent) diabetes mellitus is not altered by short-term deterioration in glycaemic control or level of postprandial insulin replacement. Lewis, G.F., O'Meara, N.M., Cabana, V.G., Blackman, J.D., Pugh, W.L., Druetzler, A.F., Lukens, J.R., Getz, G.S., Polonsky, K.S. Diabetologia (1991) [Pubmed]
  22. Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Bearcroft, C.P., Perrett, D., Farthing, M.J. Gut (1998) [Pubmed]
  23. Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state. Guerin, M., Egger, P., Soudant, C., Le Goff, W., van Tol, A., Dupuis, R., Chapman, M.J. J. Lipid Res. (2002) [Pubmed]
  24. Possibility of postprandial electrogastrography for evaluating vagal/nonvagal cholinergic activity in humans, through simultaneous analysis of postprandial heart rate variability and serum immunoreactive hormone levels. Kaneko, H., Sakakibara, M., Mitsuma, T., Morise, K. Am. J. Gastroenterol. (1995) [Pubmed]
  25. The influence of the colon on postprandial glucagon-like peptide 1 (7-36) amide concentration in man. Robertson, M.D., Livesey, G., Morgan, L.M., Hampton, S.M., Mathers, J.C. J. Endocrinol. (1999) [Pubmed]
  26. Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. Gebhard, B., Holst, J.J., Biegelmayer, C., Miholic, J. Dig. Dis. Sci. (2001) [Pubmed]
  27. Motilin and the postprandial motility of the antrum. Boivin, M., Riberdy, M., Raymond, M.C., Trudel, L., Poitras, P. Can. J. Physiol. Pharmacol. (1992) [Pubmed]
  28. Temporal pattern of de novo lipogenesis in the postprandial state in healthy men. Timlin, M.T., Parks, E.J. Am. J. Clin. Nutr. (2005) [Pubmed]
  29. Effectiveness of positioning therapy for gastroesophageal reflux. Meyers, W.F., Herbst, J.J. Pediatrics (1982) [Pubmed]
  30. Somatostatin induces ectopic activity fronts via a local intestinal mechanism during fed state or pentagastrin. Schippers, E., Janssens, J., Vantrappen, G., Vandeweerd, M., Peeters, T.L. Am. J. Physiol. (1986) [Pubmed]
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