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Gene Review

NOVA1  -  neuro-oncological ventral antigen 1

Homo sapiens

Synonyms: Neuro-oncological ventral antigen 1, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, RNA-binding protein Nova-1, Ventral neuron-specific protein 1
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Disease relevance of NOVA1


Psychiatry related information on NOVA1

  • PURPOSE: This study examined the average time spent in moderate or more intense physical activities according to weight status in randomly selected Nova Scotia students [6].
  • A boy from New York traveling in Nova Scotia had olfactory hallucinations and other signs of temporal lobe involvement, leading to a diagnosis of herpes simplex encephalitis [7].
  • In addition, we will present recent findings on other neural RNA-binding proteins: the ribonucleoprotein K homology (KH)-domain proteins, Fragile X mental retardation protein (FMRP), quakinguiable protein (QKI), and Nova-1 [8].
  • Data were collected from three community mental health centres over a 6-year period (n = 7,220) in a semi-rural region of Nova Scotia, Canada. V-code patients represented approximately one-third of the psychiatric out-patient admission in these centres [9].
  • Alcohol, tobacco and cannabis use among Nova Scotia adolescents: implications for prevention and harm reduction [10].

High impact information on NOVA1

  • Mammalian Nova antigens (1 and 2) constitute an important family of regulators of RNA metabolism in neurons, first identified using sera from cancer patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) [3].
  • Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA [11].
  • During the life cycle of the hypotrichous ciliate Oxytricha nova, a macronucleus containing short, gene-sized DNA molecules is produced from a copy of the chromosomal micronuclear genome [12].
  • We have used the presence of conserved sequence elements in the promoter and template regions to amplify by PCR the telomerase RNA genes from six different hypotrichous ciliates: Oxytricha nova, Oxytricha trifallax, Stylonychia mytilis, Stylonychia lemnae, Euplotes aediculatus, and Euplotes eurystomus [13].
  • The results suggest that multiple, but closely spaced, chromosome fragmentation sites are used by Oxytricha nova [14].

Chemical compound and disease context of NOVA1

  • Despite slight worsening of glucose tolerance, Diane Nova is an efficient treatment for women with hyperandrogenism and hirsutism [15].
  • Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada [16].
  • MICs of two new carbapenems, meropenem and L-627, and imipenem were determined against 98 strains of the Nocardia asteroides group (i.e. N. asteroides sensu stricto, Nocardia farcinica and Nocardia nova), 46 strains of Nocardia brasiliensis and 17 strains of Nocardia otitidiscaviarum [17].
  • The susceptibility of 113 strains of pathogenic Nocardia, N. asteroides, N. farcinica, N. nova, N. brasiliensis and N. otitidiscaviarum to a new oxacephem antibiotic flomoxef was determined by an agar dilution method in comparison with those of 13 other cephalosporins [18].
  • Moreover, for all Nocardia nova isolates tested, ampicillin susceptibility results by any of the testing methods were not in agreement with the results of testing for beta-lactamase by the nitrocefin (Cefinase) disk method [19].

Biological context of NOVA1

  • Screening of a human brain cDNA library with this exon identified a 1.9 kb cDNA with extensive homology to NOVA1, including three nearly identical KH domains characteristic of a subtype of RNA-binding proteins [1].
  • Since Nova encodes a target antigen in the motor disorder paraneoplastic opsoclonus-ataxia that is expressed in the developing subcortical motor system, it is a likely participant in both the pathogenesis of paraneoplastic opsoclonus-ataxia and the developmental biology of the motor system [20].
  • The homology between Nova and hnRNP K suggests that Nova regulates RNA splicing or metabolism in a specific subset of developing neurons [20].
  • Nova-1 KH domains mediate this RNA binding, and point mutations within them abrogate binding [2].
  • Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder associated with breast cancer and motor dysfunction, is a neuron-specific nuclear RNA binding protein [21].

Anatomical context of NOVA1

  • Nova expression is restricted to the ventral brain stem and spinal cord in E18 mice [20].
  • pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland [4].
  • These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system [22].
  • The laboratory information system of the Department of Pathology, Capital Health, Halifax, Nova Scotia was searched for lymph node (LN)-positive RAs resected by low anterior resection or APR in male patients between January 1, 1992 and December 31, 2002 [23].
  • The kidneys, liver, and corneas were harvested from a child who died in Nova Scotia. Several days postmortem it was learned that culture of a premortem endotracheal tube aspirate from the donor yielded MRSA [24].

Associations of NOVA1 with chemical compounds

  • Consensus [UCAU (N)(0-2)], elements were identified in two neuronal pre-mRNAs, one encoding the inhibitory glycine receptor alpha2 (GlyR alpha2) and a second encoding Nova-1 itself [21].
  • The loop region of these RNAs harbors a approximately 15-bp pyrimidine-rich element [UCAU(N)(0-2)]3 which is essential for Nova-1 binding [21].
  • OBJECTIVES: The purpose of this research was to evaluate the wear patterns of three posterior composites (Clearfil Posterior. Occlusin and P-30) and two amalgams (New True Dentalloy, Solila Nova) after 5 years' clinical service [25].
  • Diane Nova significantly decreased serum testosterone and increased serum sex hormone-binding globulin concentrations and glucose area under the curve during oral glucose tolerance test [15].
  • This complex is between a dimeric antiparallel G-quadruplex formed from the Oxytricha nova telomeric DNA sequence d(GGGGTTTTGGGG), and a di-substituted aminoalkylamido acridine compound [26].

Other interactions of NOVA1

  • We have therefore named the gene ANOVA, for astrocytic NOVA1-like gene [1].

Analytical, diagnostic and therapeutic context of NOVA1


  1. ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3. Ueki, K., Ramaswamy, S., Billings, S.J., Mohrenweiser, H.W., Louis, D.N. Neurogenetics (1997) [Pubmed]
  2. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. Buckanovich, R.J., Yang, Y.Y., Darnell, R.B. J. Neurosci. (1996) [Pubmed]
  3. Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. Lewis, H.A., Musunuru, K., Jensen, K.B., Edo, C., Chen, H., Darnell, R.B., Burley, S.K. Cell (2000) [Pubmed]
  4. pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland. Seshaiah, P., Miller, B., Myat, M.M., Andrew, D.J. Dev. Biol. (2001) [Pubmed]
  5. Placental tissue interleukin-10 receptor distribution in pre-eclampsia. Hennessy, A., Painter, D.M., Orange, S., Horvath, J.S. Am. J. Reprod. Immunol. (2003) [Pubmed]
  6. Physical activity and body mass index in grade 3, 7, and 11 Nova Scotia students. Thompson, A.M., Campagna, P.D., Rehman, L.A., Murphy, R.J., Rasmussen, R.L., Ness, G.W. Medicine and science in sports and exercise. (2005) [Pubmed]
  7. Powassan virus encephalitis resembling herpes simplex encephalitis. Embil, J.A., Camfield, P., Artsob, H., Chase, D.P. Arch. Intern. Med. (1983) [Pubmed]
  8. Role of HuD and other RNA-binding proteins in neural development and plasticity. Perrone-Bizzozero, N., Bolognani, F. J. Neurosci. Res. (2002) [Pubmed]
  9. Use of mental health resources in the treatment of adult out-patients with no diagnosable mental disorders. Siddique, C.M., Aubry, T. Acta psychiatrica Scandinavica. (1997) [Pubmed]
  10. Alcohol, tobacco and cannabis use among Nova Scotia adolescents: implications for prevention and harm reduction. Poulin, C., Elliott, D. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1997) [Pubmed]
  11. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA. Horvath, M.P., Schweiker, V.L., Bevilacqua, J.M., Ruggles, J.A., Schultz, S.C. Cell (1998) [Pubmed]
  12. Internal sequences are eliminated from genes during macronuclear development in the ciliated protozoan Oxytricha nova. Klobutcher, L.A., Jahn, C.L., Prescott, D.M. Cell (1984) [Pubmed]
  13. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Lingner, J., Hendrick, L.L., Cech, T.R. Genes Dev. (1994) [Pubmed]
  14. Characterization of chromosome fragmentation in two protozoans and identification of a candidate fragmentation sequence in Euplotes crassus. Baird, S.E., Klobutcher, L.A. Genes Dev. (1989) [Pubmed]
  15. Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study. Morin-Papunen, L.C., Vauhkonen, I., Koivunen, R.M., Ruokonen, A., Martikainen, H.K., Tapanainen, J.S. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  16. Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada. Clarke, B., Hiltz, M., Musgrave, H., Forward, K.R. Emerging Infect. Dis. (2003) [Pubmed]
  17. In-vitro activity of new carbapenem antibiotics: comparative studies with meropenem, L-627 and imipenem against pathogenic Nocardia spp. Yazawa, K., Mikami, Y., Ohashi, S., Miyaji, M., Ichihara, Y., Nishimura, C. J. Antimicrob. Chemother. (1992) [Pubmed]
  18. In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins. Yazawa, K., Mikami, Y., Uno, J., Otozai, K., Arai, T. J. Antimicrob. Chemother. (1989) [Pubmed]
  19. Comparison of agar dilution, broth microdilution, disk diffusion, E-test, and BACTEC radiometric methods for antimicrobial susceptibility testing of clinical isolates of the Nocardia asteroides complex. Ambaye, A., Kohner, P.C., Wollan, P.C., Roberts, K.L., Roberts, G.D., Cockerill, F.R. J. Clin. Microbiol. (1997) [Pubmed]
  20. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Buckanovich, R.J., Posner, J.B., Darnell, R.B. Neuron (1993) [Pubmed]
  21. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. Buckanovich, R.J., Darnell, R.B. Mol. Cell. Biol. (1997) [Pubmed]
  22. Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma. Wirtz, P.W., Sillevis Smitt, P.A., Hoff, J.I., de Leeuw, B., Lammers, G.J., van Duinen, S.G., Verschuuren, J.J. J. Neurol. (2002) [Pubmed]
  23. Spread of prostate carcinoma to the perirectal lymph node basin: analysis of 112 rectal resections over a 10-year span for primary rectal adenocarcinoma. Murray, S.K., Breau, R.H., Guha, A.K., Gupta, R. Am. J. Surg. Pathol. (2004) [Pubmed]
  24. Cross-Canada spread of methicillin-resistant Staphylococcus aureus via transplant organs. Johnston, L., Chui, L., Chang, N., Macdonald, S., McKenzie, M., Kennedy, W., Haldane, D., Bethune, R., Taylor, G., Hanakowski, M., Tyrrell, G. Clin. Infect. Dis. (1999) [Pubmed]
  25. Wear patterns in two amalgams and three posterior composites after 5 years' clinical service. Mair, L.H. Journal of dentistry. (1995) [Pubmed]
  26. Structure of a G-quadruplex-ligand complex. Haider, S.M., Parkinson, G.N., Neidle, S. J. Mol. Biol. (2003) [Pubmed]
  27. Comparison of a trial of labor with an elective second cesarean section. McMahon, M.J., Luther, E.R., Bowes, W.A., Olshan, A.F. N. Engl. J. Med. (1996) [Pubmed]
  28. Pneumonia associated with the TWAR strain of Chlamydia. Marrie, T.J., Grayston, J.T., Wang, S.P., Kuo, C.C. Ann. Intern. Med. (1987) [Pubmed]
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