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Gene Review

FGF5  -  fibroblast growth factor 5

Homo sapiens

Synonyms: FGF-5, Fibroblast growth factor 5, HBGF-5, Heparin-binding growth factor 5, Smag-82, ...
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Disease relevance of FGF5


High impact information on FGF5

  • In a model of stress-induced myocardial ischemia, intracoronary injection of a recombinant adenovirus expressing human fibroblast growth factor-5 (FGF-5) resulted in messenger RNA and protein expression of the transferred gene [5].
  • Northern analysis of total RNA from rat skeletal muscle revealed an FGF-5 mRNA transcript both during the period of embryonic motoneuron death and in the adult [6].
  • Hair follicles from PG and DeltaN80PG mice show premature termination of the growth phase (anagen) of the hair cycle, an event that is regulated in part by FGF5 (Hebert et al. 1994) [7].
  • The BEK receptor expressed in Chinese hamster ovary cells binds acidic FGF, basic FGF, and Kaposi FGF equally well but does not bind keratinocyte growth factor or FGF-5 appreciably [8].
  • The introduction of these ORF-1 mutations into a eukaryotic FGF-5 expression vector increases its capacity to transform mouse NIH 3T3 cells up to 50-fold upon transfection [9].

Chemical compound and disease context of FGF5


Biological context of FGF5

  • The membranes were immunostained with an affinity purified rabbit polyclonal antibody raised against the amino acid sequence for residues 175 to 185 of human FGF5 and visualized with the silver enhanced colloidal gold method for light microscopy [2].
  • In our study, we show a synteny between EGF and the genes PDHA2 and FGF5 (from HSA 4q) and microsatellites ILSTS018, ILSTS090, and ILSTS093 (from bovine chromosome 6) in sheep [11].
  • These observations suggest that FGF-5 may participate in autocrine and paracrine pathways promoting pancreatic cancer cell growth in vivo [3].
  • To elucidate the inherent participation of FGF5 during limb organogenesis, a retroviral delivery system (RCAS) was used to overexpress human FGF5 throughout developing hind limb of chicken embryos [12].
  • We now term this oncogene the FGF-5 gene, since it specifies the fifth documented protein related to fibroblast growth factors (FGFs [13].

Anatomical context of FGF5


Associations of FGF5 with chemical compounds

  • Although both of these agents which are FGF binding antagonists were found to inhibit the incorporation of 3H thymidine in KS-derived cultured cells, increased expression of bFGF, FGF5 and the FGF receptor was observed after the KS cells were exposed to these substances [16].
  • FGF-5 is secreted from transfected 3T3 cells and from human tumor cells as glycoproteins containing heterogeneous amounts of sialic acid [9].
  • Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells [17].
  • Here we show that C2 cells recognize human leukocyte antigen-A3 MHC class I molecules presenting a nine-residue FGF-5 peptide generated by protein splicing [10].

Other interactions of FGF5

  • METHODS: Influenza infection and adenovirus-mediated gene transfer were used to deliver and express genes encoding influenza hemagglutinin (HA), p75-NTR (a neurotrophin receptor), low-density lipoprotein (LDL) receptor (LDLR), and FGF5 in confluent monolayers of ARPE-19 cells [14].
  • COLO-357 cells expressed the IIIc isoform of the type I FGF receptor, the preferred FGF receptor for FGF-5 [3].
  • In this study the role of FGF-5 in human pancreatic cancer was investigated, as FGF-5 has a classical signal sequence for secretion not found in FGF-1 or -2 [3].
  • Exogeneous FGF-5 (0.37 nM) increased the growth of COLO-357 cells by 48% (P < 0.0001) and increased mitogen-activated protein kinase activity [3].
  • Additional mRNA transcripts encoding FGF-5 and FGF-7 were expressed by RA, but not normal, synovial cells in culture [18].

Analytical, diagnostic and therapeutic context of FGF5


  1. Expression of fibroblast growth factor gene family and its receptor gene family in the human upper gastrointestinal tract. Iida, S., Katoh, O., Tokunaga, A., Terada, M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  2. Expression of FGF5 in choroidal neovascular membranes associated with ARMD. Kitaoka, T., Morse, L.S., Schneeberger, S., Ishigooka, H., Hjelmeland, L.M. Curr. Eye Res. (1997) [Pubmed]
  3. Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. Kornmann, M., Ishiwata, T., Beger, H.G., Korc, M. Oncogene (1997) [Pubmed]
  4. Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization. Xerri, L., Hassoun, J., Planche, J., Guigou, V., Grob, J.J., Parc, P., Birnbaum, D., deLapeyriere, O. Am. J. Pathol. (1991) [Pubmed]
  5. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Giordano, F.J., Ping, P., McKirnan, M.D., Nozaki, S., DeMaria, A.N., Dillmann, W.H., Mathieu-Costello, O., Hammond, H.K. Nat. Med. (1996) [Pubmed]
  6. Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons. Hughes, R.A., Sendtner, M., Goldfarb, M., Lindholm, D., Thoenen, H. Neuron (1993) [Pubmed]
  7. Plakoglobin suppresses epithelial proliferation and hair growth in vivo. Charpentier, E., Lavker, R.M., Acquista, E., Cowin, P. J. Cell Biol. (2000) [Pubmed]
  8. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. Mansukhani, A., Dell'Era, P., Moscatelli, D., Kornbluth, S., Hanafusa, H., Basilico, C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Biosynthesis of human fibroblast growth factor-5. Bates, B., Hardin, J., Zhan, X., Drickamer, K., Goldfarb, M. Mol. Cell. Biol. (1991) [Pubmed]
  10. Immune recognition of a human renal cancer antigen through post-translational protein splicing. Hanada, K., Yewdell, J.W., Yang, J.C. Nature (2004) [Pubmed]
  11. Synteny conservation between parts of human chromosome 4q and bovine and ovine chromosomes 6. Lanneluc, I., Mulsant, P., Saidi-Mehtar, N., Elsen, J.M. Cytogenet. Cell Genet. (1996) [Pubmed]
  12. FGF5 stimulates expansion of connective tissue fibroblasts and inhibits skeletal muscle development in the limb. Clase, K.L., Mitchell, P.J., Ward, P.J., Dorman, C.M., Johnson, S.E., Hannon, K. Dev. Dyn. (2000) [Pubmed]
  13. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Zhan, X., Bates, B., Hu, X.G., Goldfarb, M. Mol. Cell. Biol. (1988) [Pubmed]
  14. Use of the ARPE-19 cell line as a model of RPE polarity: basolateral secretion of FGF5. Dunn, K.C., Marmorstein, A.D., Bonilha, V.L., Rodriguez-Boulan, E., Giordano, F., Hjelmeland, L.M. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  15. An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. Ozawa, K., Suzuki, S., Asada, M., Tomooka, Y., Li, A.J., Yoneda, A., Komi, A., Imamura, T. J. Biol. Chem. (1998) [Pubmed]
  16. Increased expression of fibroblast growth factors (FGFs) and their receptor by protamine and suramin on Kaposi's sarcoma-derived cells. Huang, Y.Q., Li, J.J., Nicolaides, A., Zhang, W.G., Friedman-Kien, A.E. Anticancer Res. (1993) [Pubmed]
  17. Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. Kornmann, M., Lopez, M.E., Beger, H.G., Korc, M. Int. J. Pancreatol. (2001) [Pubmed]
  18. Regulation of synovial cell growth. Coexpression of transforming growth factor beta and basic fibroblast growth factor by cultured synovial cells. Goddard, D.H., Grossman, S.L., Williams, W.V., Weiner, D.B., Gross, J.L., Eidsvoog, K., Dasch, J.R. Arthritis Rheum. (1992) [Pubmed]
  19. Expression of fibroblast growth factors and their receptors in acquired immunodeficiency syndrome-associated Kaposi sarcoma tissue and derived cells. Li, J.J., Huang, Y.Q., Moscatelli, D., Nicolaides, A., Zhang, W.C., Friedman-Kien, A.E. Cancer (1993) [Pubmed]
  20. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. Hanada , K., Perry-Lalley, D.M., Ohnmacht, G.A., Bettinotti, M.P., Yang, J.C. Cancer Res. (2001) [Pubmed]
  21. Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18. Green, E.S., Rendahl, K.G., Zhou, S., Ladner, M., Coyne, M., Srivastava, R., Manning, W.C., Flannery, J.G. Mol. Ther. (2001) [Pubmed]
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