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MeSH Review

Pancreas, Artificial

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Disease relevance of Pancreas, Artificial


High impact information on Pancreas, Artificial


Biological context of Pancreas, Artificial


Anatomical context of Pancreas, Artificial

  • Optimal blood glucose control for 5 +/- 2 days using an external artificial pancreas led to a rapid normalisation of membrane marker values and mitogen responsiveness of lymphocytes from previously poorly controlled diabetics [12].
  • The large differences in properties among membranes made with different chemical formulations suggest that glucose-sensitive membranes with performance characteristics needed for an artificial pancreas may be an achievable goal [13].
  • The artificial pancreas produced a stable glycemic baseline before surgery, prevented hypoglycemia during palpation of the pancreas and manipulation of the tumor, and indirectly amplified small decreases in the blood sugar level with large increases in the rate of dextrose infusion [14].
  • A copolymer of N-isopropylacrylamide (98 mol% in feed) and acrylic acid, poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAAm-co-AAc)), was prepared by free radical polymerization for development of a thermally reversible polymer to entrap islets of Langerhans for a refillable biohybrid artificial pancreas [15].

Associations of Pancreas, Artificial with chemical compounds


Gene context of Pancreas, Artificial


Analytical, diagnostic and therapeutic context of Pancreas, Artificial


  1. Dextrose infusion by artificial pancreas in diagnosis of insulinoma. Trovati, M., Pagano, G., Cartia, Q., Lorenzati, R., Cavalot, F., Vitali, S., Caselle, M.T., Lenti, G. Lancet (1982) [Pubmed]
  2. Advances toward the implantable artificial pancreas for treatment of diabetes. Jaremko, J., Rorstad, O. Diabetes Care (1998) [Pubmed]
  3. Hyperglycemic effect of sucrose ingestion in IDDM patients controlled by artificial pancreas. Forlani, G., Galuppi, V., Santacroce, G., Braione, A.F., Giangiulio, S., Ciavarella, A., Vannini, P. Diabetes Care (1989) [Pubmed]
  4. Beta-thromboglobulin levels in diabetes mellitus: influence of degenerative lesions and glycemic regulation using an artificial pancreas. Voisin, P., Rousselle, D., Drouin, P., Stoltz, J.F. Thromb. Res. (1983) [Pubmed]
  5. Glucose stabilization and coronary infarction with artificial pancreas in heart-lung preparation. Pisanty, J., Chávez, R., Bracho, A., Herrera, P. Life support systems : the journal of the European Society for Artificial Organs. (1985) [Pubmed]
  6. Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats. Chick, W.L., Perna, J.J., Lauris, V., Low, D., Galletti, P.M., Panol, G., Whittemore, A.D., Like, A.A., Colton, C.K., Lysaght, M.J. Science (1977) [Pubmed]
  7. Glucagon and blood glucose: insights from artificial pancreas studies. Felig, P., Sherwin, R.S. Ann. Intern. Med. (1980) [Pubmed]
  8. Hyperalaninaemia is an early feature of diabetes secondary to total pancreatectomy. Del Prato, S., Vigili de Kreutzenberg, S., Trevisan, R., Duner, E., Avogaro, A., Nosadini, R., Baccaglini, U., Tremolada, C., Tiengo, A. Diabetologia (1985) [Pubmed]
  9. Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes. Pagano, G., Tagliaferro, V., Carta, Q., Caselle, M.T., Bozzo, C., Vitelli, F., Trovati, M., Cocuzza, E. Diabetologia (1983) [Pubmed]
  10. Type 1 diabetes developed in a type 2 diabetic patient with severe insulin resistance. Suehiro, T., Osaki, F., Ikeda, Y., Arii, K., Nakayama, F., Ota, K., Hashimoto, K. Diabetes Res. Clin. Pract. (2005) [Pubmed]
  11. Extracorporeal determination of glucose, lactate and potassium with electrochemical biosensors. Mascini, M., Palleschi, G., Moscone, D., Bernardi, L. Journal of pharmaceutical and biomedical analysis. (1989) [Pubmed]
  12. Circulating lymphocyte subpopulations in juvenile insulin-dependent diabetes. Correction of abnormalities by adequate blood glucose control. Selam, J.L., Clot, J., Andary, M., Mirouze, J. Diabetologia (1979) [Pubmed]
  13. Glucose-sensitive membranes containing glucose oxidase: activity, swelling, and permeability studies. Kost, J., Horbett, T.A., Ratner, B.D., Singh, M. J. Biomed. Mater. Res. (1985) [Pubmed]
  14. Artificial pancreas as an aid during insulinoma resection. Duncan, W.E., Duncan, T.G., DeLaurentis, D.A., Kryston, L., Kaminski, K., Paskin, D.L. Am. J. Surg. (1981) [Pubmed]
  15. Insulin release from islets of Langerhans entrapped in a poly(N-isopropylacrylamide-co-acrylic acid) polymer gel. Vernon, B., Kim, S.W., Bae, Y.H. Journal of biomaterials science. Polymer edition. (1999) [Pubmed]
  16. Somatostatin analog SMS 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas. Rios, M.S., Navascues, I., Saban, J., Ordoñez, A., Sevilla, F., Del Pozo, E. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  17. An L-lactate sensor with immobilized enzyme for use in in vivo studies with an endocrine artificial pancreas. Mascini, M., Fortunati, S., Moscone, D., Palleschi, G., Massi-Benedetti, M., Fabietti, P. Clin. Chem. (1985) [Pubmed]
  18. Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas. Burczak, K., Gamian, E., Kochman, A. Biomaterials (1996) [Pubmed]
  19. The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia. Vague, P., Moulin, J.P. Metab. Clin. Exp. (1982) [Pubmed]
  20. Close relationship of tissue plasminogen activator-plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas. Hoshino, M., Haraguchi, Y., Hirasawa, H., Sakai, M., Saegusa, H., Hayashi, K., Horita, N., Ohsawa, H. Critical care (London, England) (2001) [Pubmed]
  21. Somatostatin and counterregulatory hormone responses to hypoglycaemia in diabetics with and without autonomic neuropathy. Fernandez-Castaner, M., Webb, S., Levy, I., Rios, M., Casamitjana, R., Bergua, M., Figuerola, D., Rivera, F. Diabète & métabolisme. (1985) [Pubmed]
  22. D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics. Neuhaus, C., Kerner, W., Maier, V., Pfeiffer, E.F. Horm. Metab. Res. Suppl. (1979) [Pubmed]
  23. Effects of somatostatin added to insulin in a glucose-controlled insulin infusion system. Selam, J.L., Chenon, D., Pham, T.C., Gagnol, J.P., Sany, C., Thomas, N., Gravagne, G., Orsetti, A., Mirouze, J. Diabetologia (1981) [Pubmed]
  24. Correlation between amount of carbohydrate in mixed meals and insulin delivery by artificial pancreas in seven IDDM subjects. Halfon, P., Belkhadir, J., Slama, G. Diabetes Care (1989) [Pubmed]
  25. Lactate and pyruvate electrochemical biosensors for whole blood in extracorporeal experiments with an endocrine artificial pancreas. Mascini, M., Mazzei, F., Moscone, D., Calabrese, G., Benedetti, M.M. Clin. Chem. (1987) [Pubmed]
  26. Insulin sensitivity and glycemic control before and after parathyroidectomy in a diabetic patient with familial multiple endocrine neoplasia type 1. Furuto-Kato, S., Shimatsu, A., Kuzuya, H., Matsuda, K., Nakao, K., Imura, H. Endocr. J. (1994) [Pubmed]
  27. Characterization of insulin resistance in type I diabetes. Kerner, W., Navascués, I., von Schrenck, T., Fussgänger, R., Arias, P., Pfeiffer, E.F. Klin. Wochenschr. (1985) [Pubmed]
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