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Gene Review

MYBL1  -  v-myb avian myeloblastosis viral oncogene...

Homo sapiens

Synonyms: A-MYB, A-Myb, A-myb, AMYB, Myb-like protein 1, ...
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Disease relevance of MYBL1


High impact information on MYBL1

  • Based on its homology to the transcription factors c-MYB and A-MYB, B-MYB is thought to be involved in transcriptional regulation; however, its activity is not detectable in several cell lines [3].
  • The Myb family of transcription factors is defined by homology within the DNA binding domain and includes c-Myb, A-Myb, and B-Myb [4].
  • The activity of c-myb and c-myc promoters, which both contain multiple MBS elements, were similarly transactivated, approximately 30- and 50-fold, respectively, upon cotransfection with human A-myb [4].
  • Treatment of SMC cultures with 5,6-dichlorobenzimidazole riboside, a selective inhibitor of RNA polymerase II, indicated an approximate 4-h half-life for A-myb mRNA during the S phase of the cell cycle [4].
  • Thus, these results suggest that A-myb is a potent transactivator in bovine SMCs and that its expression induces progression into S phase of the cell cycle [4].

Biological context of MYBL1


Anatomical context of MYBL1


Associations of MYBL1 with chemical compounds

  • IGF-I and A-myb were up-regulated in estrogen-treated cells while MKP-1 was down-regulated [10].
  • Indeed, cotransfection of A-Myb or c-Myb expression vectors in HEK293 and BL-2 cells suppressed STAT6-dependent transcription from a reporter construct containing four copies of the IL-4RE cloned upstream of a minimal thymidine kinase promoter [11].

Physical interactions of MYBL1

  • We identify nucleolin as one of the nuclear polypeptides that interact specifically with the A-Myb and c-Myb, but not B-Myb DNA-binding domains [12].
  • The DNA binding domain of the A-MYB transcription factor is responsible for its B cell-specific activity and binds to a B cell 110-kDa nuclear protein [13].

Enzymatic interactions of MYBL1


Regulatory relationships of MYBL1

  • Furthermore, NLK induced the methylation of histone H3 at lysine-9 at A-Myb-bound promoter regions [14].
  • The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3 [14].
  • Most importantly, overexpression of A-Myb was sufficient to suppress IL-4-induced endogenous epsilon GL transcription in BL-2 cells [11].

Other interactions of MYBL1


Analytical, diagnostic and therapeutic context of MYBL1

  • Binding of the A-myb protein is shown in gel retardation assays to be specific for the classical c-myb recognition sequence PyAACG/TG [8].
  • We have shown previously by PCR analysis that A-myb is preferentially expressed in CD38+ CD39- sIgM- mature B cells [15].


  1. Chromosome locations of the MYB related genes, AMYB and BMYB. Barletta, C., Druck, T., LaForgia, S., Calabretta, B., Drabkin, H., Patterson, D., Croce, C.M., Huebner, K. Cancer Res. (1991) [Pubmed]
  2. Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. Golay, J., Luppi, M., Songia, S., Palvarini, C., Lombardi, L., Aiello, A., Delia, D., Lam, K., Crawford, D.H., Biondi, A., Barbui, T., Rambaldi, A., Introna, M. Blood (1996) [Pubmed]
  3. Activation of human B-MYB by cyclins. Sala, A., Kundu, M., Casella, I., Engelhard, A., Calabretta, B., Grasso, L., Paggi, M.G., Giordano, A., Watson, R.J., Khalili, K., Peschle, C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase. Marhamati, D.J., Bellas, R.E., Arsura, M., Kypreos, K.E., Sonenshein, G.E. Mol. Cell. Biol. (1997) [Pubmed]
  5. Functional domains of the human B-myb gene product. Nakagoshi, H., Takemoto, Y., Ishii, S. J. Biol. Chem. (1993) [Pubmed]
  6. DNA binding and transactivation activity of A-myb, a c-myb-related gene. Ma, X.P., Calabretta, B. Cancer Res. (1994) [Pubmed]
  7. Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nomura, N., Takahashi, M., Matsui, M., Ishii, S., Date, T., Sasamoto, S., Ishizaki, R. Nucleic Acids Res. (1988) [Pubmed]
  8. The human A-myb protein is a strong activator of transcription. Golay, J., Loffarelli, L., Luppi, M., Castellano, M., Introna, M. Oncogene (1994) [Pubmed]
  9. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. Takahashi, T., Nakagoshi, H., Sarai, A., Nomura, N., Yamamoto, T., Ishii, S. FEBS Lett. (1995) [Pubmed]
  10. Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines. Swartz, C.D., Afshari, C.A., Yu, L., Hall, K.E., Dixon, D. Mol. Hum. Reprod. (2005) [Pubmed]
  11. Myb proteins repress human Ig epsilon germline transcription by inhibiting STAT6-dependent promoter activation. Monticelli, S., Ghittoni, R., Kabesch, M., Vercelli, D. Mol. Immunol. (2002) [Pubmed]
  12. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. Ying, G.G., Proost, P., van Damme, J., Bruschi, M., Introna, M., Golay, J. J. Biol. Chem. (2000) [Pubmed]
  13. The DNA binding domain of the A-MYB transcription factor is responsible for its B cell-specific activity and binds to a B cell 110-kDa nuclear protein. Ying, G.G., Arsura, M., Introna, M., Golay, J. J. Biol. Chem. (1997) [Pubmed]
  14. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Kurahashi, T., Nomura, T., Kanei-Ishii, C., Shinkai, Y., Ishii, S. Mol. Biol. Cell (2005) [Pubmed]
  15. The A-Myb transcription factor is a marker of centroblasts in vivo. Golay, J., Broccoli, V., Lamorte, G., Bifulco, C., Parravicini, C., Pizzey, A., Thomas, N.S., Delia, D., Ferrauti, P., Vitolo, D., Introna, M. J. Immunol. (1998) [Pubmed]
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