Disease relevance of ERICH1

• Immunogenicity of the Plasmodium falciparum glutamate-rich protein expressed by vaccinia virus [1].
• Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria [2].
• A fragment of the 220 kDa P. falciparum glutamate rich protein containing amino acid residues 489-1271 was expressed in E. coli as a recombinant chimeric beta-galactosidase fusion protein and used as antigen after purification and biotinylation [3].
• Re: Olav Erich Yri, Trine Bjoro and Sophie D. Fossa. Failure to achieve castration levels in patients using leupoprolide acetate in locally advanced prostate cancer. Eur Urol 2006;49:54-8 [4].
• The antigenicity of the glutamate-rich protein (GLURP) of Plasmodium falciparum was comprehensively evaluated in epitope-mapping studies utilizing a phage display library, synthetic peptides and anti-GLURP IgG preparations previously shown to promote strong antibody-dependent cellular inhibition (ADCI) effects [5].

Psychiatry related information on ERICH1

• Erich Lindemann: the humanist and the era of community mental health [6].
• The child: Erich Neumann's contribution to the psychopathology of child development [7].

High impact information on ERICH1

• We found that in Ca(2+) overlay and Stains-all assays, ARC protein bound to Ca(2+) through the C-terminal proline/glutamate-rich (P/E-rich) domain [8].
• IC(50) values for [(3)H]ryanodine binding suggested that Ca(2+) affinity for the low affinity Ca(2+) inactivation sites was unchanged in a chimera in which a glutamate-rich sequence (amino acids 1743-1964) in RyR1 was replaced with the corresponding, less acidic sequence from RyR2 [9].
• These results indicate that the gamma-carboxylation recognition site within the prothrombin propeptide in a prothrombin propeptide-thrombin chimeric protein is sufficient to direct gamma-carboxylase-catalyzed carboxylation of adjacent glutamic acid residues in a glutamate-rich region of thrombin that is not normally gamma-carboxylated [10].
• A propeptide/thrombin chimeric protein, constructed by deleting the Gla, aromatic amino acid stack, and kringle domains of prothrombin, has the signal peptide and propeptide juxtaposed to a glutamate-rich COOH-terminal region of prothrombin, residues 249-530 [10].
• Four segments (comprising the signal sequence, a short, 15-amino acid, glutamate-rich sequence, the functional toxin, and 2 glycine residues) can be distinguished [11].

Biological context of ERICH1

• Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein: correlation with clinical immunity in Gambian children [12].
• Genotyping with regards to the three highly polymorphic antigen-coding regions (merozoite surface protein-1 [msp-1], msp-2, and the glutamate-rich protein [glurp]) revealed multiple genotypes (up to five) in 64% of the patients [13].
• Classic pages in obstetrics and gynecology. Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillomen. Fritz Richard Schaudinn and Erich Hoffmann. Arbeiten aus dem kaiserlichen Gesundheitsamtes (Berlin), vol. 22, pp. 527-534, 1905 [14].
• The aim of this study was to validate a computerized metabolic system with mixing chamber (Oxycon Pro, Erich Jaeger GmbH, Hoechberg, Germany) against the Douglas bag method (1) over a large range of ventilations and (2) for drift during shorter (25-min time trial) and longer (approximately three months) test periods [15].
• Erich Fischer-brügge (28.12.1904-4.2.1951) - founder of neurosurgery at the university of münster [16].

Anatomical context of ERICH1

• Another peptide, alpha-syn(120-140), which corresponds to the glutamate-rich C-terminal region, also associates weakly with lipid headgroups but with a slightly higher affinity for membranes with no net surface charge than for negatively charged membrane surfaces [17].
• These observations raise the possibility of transplacental poisoning in human fetuses after the consumption of glutamate-rich food by the mother [18].
• Surgical reconstruction was performed, utilizing Erich dental arch bars for external stenting [19].
• Identification of a major B-cell epitope of the Plasmodium falciparum glutamate-rich protein (GLURP), targeted by human antibodies mediating parasite killing [5].
• A ribosome inactivating peptide, with an N-terminal sequence exhibiting pronounced similarity to that of the 6.5 kDa-arginine/glutamate-rich polypeptide from Luffa cylindrica seeds, was isolated from seeds of a closely related species, the ridge gourd Luffa acutangula [20].

Associations of ERICH1 with chemical compounds

• Excision of the more distal glutamate-rich region appears to be signaled by flanking arginine residues but likely occurs only after a disulfide linkage has formed between the major and minor chains of the mature toxin [21].
• Re: olav erich yri, trine bjoro and sophie d. Fossa. Failure to achieve castration levels in patients using leuprolide acetate in locally advanced prostate cancer. Eur urol 2006;49:54-58 [22].
• An aspartate- and glutamate-rich portion of hirudin plays an important part in its tight binding to thrombin through a ladder of salt bridges, and these residues have previously been mutated to asparagine or glutamine [23].
• The deleted region includes one or two TRH progenitor sequences flanked by some glutamate residues, similar to the glutamate-rich regions of human ppTRH [24].
• The gas-analyser Eos Sprint ("Erich Jaeger", Germany) was used [25].

Other interactions of ERICH1

• GRWD1 encodes a 446-amino-acid protein containing a glutamate-rich region followed by four WD repeats [26].
• These included four proline-rich proteins, a small protein that is similar to the non-catalytic, N-terminal domain of some pectin methylesterases, and two other glutamate-rich proteins [27].
• The Wcor410 cDNA contains an ORF encoding a dehydrin-like glutamate-rich protein of 28 kDa with a pI of 5 [28].
• The ambulance purchasing process: Part 1. Interview by John Erich [29].
• Anarchism and homosexuality in Wilhelmine Germany: Senna Hoy, Erich Mühsam, John Henry Mackay [30].

Analytical, diagnostic and therapeutic context of ERICH1

• Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP) [2].
• Recombinant Plasmodium falciparum glutamate rich protein; purification and use in enzyme-linked immunosorbent assay [31].
• Genetic variability was determined by sequence analysis of the polymorphic segments of the merozoite surface protein 2 (msp-2) and glutamate-rich protein (glurp) genes [32].
• We examined the impact of chemoprophylaxis on the cellular and humoral immune responses to polypeptides of the asexual Plasmodium falciparum blood stage antigens, the glutamate rich protein GLURP and Pf155/RESA, both of which in previous field studies have been identified as potentially protective antigens [33].
• In a cross-sectional study, 180 young Gabonese children with and without sickle cell trait and harboring asymptomatic Plasmodium falciparum infections, were assessed for the responses to recombinant protein containing the conserved region of glutamate-rich protein (GLURP) [34].

References