Disease relevance of Lantana

• Lantadene A content and toxicity of the lantana plant (Lantana camara, Linn.) to guinea pigs [1].
• CONCLUSION: The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effect due to Lantana camara constituents and attests to its possible utility in secretory and functional diarrheas and other gastrointestinal disorders [2].
• The anti-inflammatory activity of Lantana trifolia (Verbenaceae) was determined by carrageenan, serotonin and histamine-induced rat paw edema and the analgesic activity of this plant was studied by acetic acid-induced writhings and tail flick tests in mice [3].
• The active extracts were tested against monoresistant variants of Mycobacterium tuberculosis H37Rv (isoniazid, rifampin, streptomycin and ethambutol resistant) and the hexane extract of Lantana hispida showed the best activity [4].

High impact information on Lantana

• The amount of lantadene A in the leaves of Lantana camara collected in the month of May quantitated by the present method was found to be 13.6 mg/g dry weight of the leaves [5].
• Three new pentacyclic triterpenoids, camaryolic acid (1), methylcamaralate (2) and camangeloyl acid (3) and six known compounds beta-sitosterol 3-O-beta-D-glucopyranoside (4), octadecanoic acid (5), docosanoic acid (6), palmitic acid (7), camaric acid (8) and lantanolic acid (9) were isolated from the aerial parts of Lantana camara [6].
• Fraxinus excelsior, M. nigra, P. avium, P. serotina, R. cathartica, and V. lantana showed more injury than A. pseudoplatanus, B. pendula, C. avellana, and Fagus sylvatica [7].
• The most to least symptomatic species grown within open-plots in this study rank as Prunus serotina, Salix viminalis, Vibrnum lantana, Rhamnus cathartica, Betula pendula, Rumex obtusifolius, Sambucus racemosa, Morus nigra, Prunus avium, Fraxinus excelsior, Rhamnus frangula, Alnus viridis, Fagus sylvatica and Acer pseudoplatanus [8].
• Triterpenoids, essential oil and photo-oxidative 28 --> 13-lactonization of oleanolic acid from Lantana camara [9].

Biological context of Lantana

• Clinical observations on four male cow calves and three other lantana poisoned animals under field conditions have been made along with hematological studies, including observations on plasma bilirubin content and osmotic fragility of erythrocytes [10].

Associations of Lantana with chemical compounds

• Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C [11].
• Umuhengerin, a new antimicrobially active flavonoid from Lantana trifolia [12].
• 1. Lantana intoxication of guinea-pig caused a decrease in hepatic microsomal protein content, the phospholipid: protein ratio, and the cholesterol: protein ratio [13].
• Two novel triterpenoids have been isolated from the roots of Lantana camara L.: 3beta,19alpha dihydroxy ursan-28-oic acid and 21,22beta-epoxy-3beta-hydroxy olean-12-en-28-oic acid in its methyl ester form [9].
• The toxic triterpene acids lantadene A and lantadene B were isolated from Lantana camara and conjugated to bovine serum albumen or haemocyanin [14].

Gene context of Lantana

• Verbascoside [1] isolated from Lantana camara is an inhibitor of protein kinase C (PKC) from the rat brain [11].

References