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Chemical Compound Review

sulphur-32     sulfane

Synonyms: Sulfur-32, CHEBI:37979, AC1L2Y5T, (32)S, (32)16S, ...
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Disease relevance of hydrogen sulfide


Psychiatry related information on hydrogen sulfide


High impact information on hydrogen sulfide


Chemical compound and disease context of hydrogen sulfide

  • We cloned, by complementation of an H2S- mutant, a cluster of Salmonella typhimurium genes, phsBCDEF, that appears to be essential for the anaerobic production of hydrogen sulfide from thiosulfate [12].
  • Volatile sulfur compounds such as hydrogen sulfide and methyl mercaptan have been associated with adult periodontitis as well as with healing surgical wounds [13].
  • Four proteins of Paracoccus pantotrophus are required for hydrogen sulfide-, sulfur-, thiosulfate- and sulfite-dependent horse heart cytochrome c reduction [14].
  • In the few intact chemosymbioses tested in previous studies, hydrogen sulfide production was shown to occur when the animal-symbiont association was exposed to anoxia and elemental sulfur stored in the thioautotrophic symbionts was proposed to serve as an electron sink in the absence of oxygen and nitrate [15].
  • Engineering hydrogen sulfide production and cadmium removal by expression of the thiosulfate reductase gene (phsABC) from Salmonella enterica serovar typhimurium in Escherichia coli [16].

Biological context of hydrogen sulfide


Anatomical context of hydrogen sulfide


Associations of hydrogen sulfide with other chemical compounds


Gene context of hydrogen sulfide


Analytical, diagnostic and therapeutic context of hydrogen sulfide


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  3. The chimeric eukaryote: origin of the nucleus from the karyomastigont in amitochondriate protists. Margulis, L., Dolan, M.F., Guerrero, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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  6. Operation of bad breath clinics. Neiders, M., Ramos, B. Quintessence international. (1999) [Pubmed]
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  11. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Wallace, J.L., Caliendo, G., Santagada, V., Cirino, G., Fiorucci, S. Gastroenterology (2007) [Pubmed]
  12. Cloning and characterization of a gene cluster, phsBCDEF, necessary for the production of hydrogen sulfide from thiosulfate by Salmonella typhimurium. Alami, N., Hallenbeck, P.C. Gene (1995) [Pubmed]
  13. Exposure of periodontal ligament cells to methyl mercaptan reduces intracellular pH and inhibits cell migration. Lancero, H., Niu, J., Johnson, P.W. J. Dent. Res. (1996) [Pubmed]
  14. The cysteine residue of the SoxY protein as the active site of protein-bound sulfur oxidation of Paracoccus pantotrophus GB17. Quentmeier, A., Friedrich, C.G. FEBS Lett. (2001) [Pubmed]
  15. Respiration strategies utilized by the gill endosymbiont from the host lucinid Codakia orbicularis (Bivalvia: Lucinidae). Duplessis, M.R., Ziebis, W., Gros, O., Caro, A., Robidart, J., Felbeck, H. Appl. Environ. Microbiol. (2004) [Pubmed]
  16. Engineering hydrogen sulfide production and cadmium removal by expression of the thiosulfate reductase gene (phsABC) from Salmonella enterica serovar typhimurium in Escherichia coli. Bang, S.W., Clark, D.S., Keasling, J.D. Appl. Environ. Microbiol. (2000) [Pubmed]
  17. Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme. Bamford, V.A., Bruno, S., Rasmussen, T., Appia-Ayme, C., Cheesman, M.R., Berks, B.C., Hemmings, A.M. EMBO J. (2002) [Pubmed]
  18. Hydrogen sulfide: from the smell of the past to the mediator of the future? Moore, P.K., Bhatia, M., Moochhala, S. Trends Pharmacol. Sci. (2003) [Pubmed]
  19. A paradox resolved: sulfide acquisition by roots of seep tubeworms sustains net chemoautotrophy. Freytag, J.K., Girguis, P.R., Bergquist, D.C., Andras, J.P., Childress, J.J., Fisher, C.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  20. Investigation of the prebiotic synthesis of amino acids and RNA bases from CO2 using FeS/H2S as a reducing agent. Keefe, A.D., Miller, S.L., McDonald, G., Bada, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  21. L-Cysteine Inhibits Insulin Release From the Pancreatic {beta}-Cell: Possible Involvement of Metabolic Production of Hydrogen Sulfide, a Novel Gasotransmitter. Kaneko, Y., Kimura, Y., Kimura, H., Niki, I. Diabetes (2006) [Pubmed]
  22. Reducing sulfur compounds of the colon impair colonocyte nutrition: implications for ulcerative colitis. Roediger, W.E., Duncan, A., Kapaniris, O., Millard, S. Gastroenterology (1993) [Pubmed]
  23. Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Meng, Q.H., Yang, G., Yang, W., Jiang, B., Wu, L., Wang, R. Am. J. Pathol. (2007) [Pubmed]
  24. Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Tang, G., Wu, L., Liang, W., Wang, R. Mol. Pharmacol. (2005) [Pubmed]
  25. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Oh, G.S., Pae, H.O., Lee, B.S., Kim, B.N., Kim, J.M., Kim, H.R., Jeon, S.B., Jeon, W.K., Chae, H.J., Chung, H.T. Free Radic. Biol. Med. (2006) [Pubmed]
  26. Activity of polymorphonuclear leukocytes in the presence of sulfide. Claesson, R., Granlund-Edstedt, M., Persson, S., Carlsson, J. Infect. Immun. (1989) [Pubmed]
  27. Persulfide generated from L-cysteine inactivates tyrosine aminotransferase. Requirement for a protein with cysteine oxidase activity and gamma-cystathionase. Hargrove, J.L. J. Biol. Chem. (1988) [Pubmed]
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  30. Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila. Beynon, J.D., MacRae, I.J., Huston, S.L., Nelson, D.C., Segel, I.H., Fisher, A.J. Biochemistry (2001) [Pubmed]
  31. Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. Bhatia, M., Zhi, L., Zhang, H., Ng, S.W., Moore, P.K. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  32. Active site cysteinyl and arginyl residues of rhodanese. A novel formation of disulfide bonds in the active site promoted by phenylglyoxal. Weng, L., Heinrikson, R.L., Westley, J. J. Biol. Chem. (1978) [Pubmed]
  33. MET17 and hydrogen sulfide formation in Saccharomyces cerevisiae. Spiropoulos, A., Bisson, L.F. Appl. Environ. Microbiol. (2000) [Pubmed]
  34. Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. Hu, L.F., Wong, P.T., Moore, P.K., Bian, J.S. J. Neurochem. (2007) [Pubmed]
  35. Endogenous hydrogen sulfide in patients with COPD. Chen, Y.H., Yao, W.Z., Geng, B., Ding, Y.L., Lu, M., Zhao, M.W., Tang, C.S. Chest (2005) [Pubmed]
  36. A thin-layer amperometric sensor for hydrogen sulfide: the use of microelectrodes to achieve a membrane-independent response for Clark-type sensors. Lawrence, N.S., Jiang, L., Jones, T.G., Compton, R.G. Anal. Chem. (2003) [Pubmed]
  37. Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Zhang, H., Zhi, L., Moore, P.K., Bhatia, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  38. Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes. Bian, J.S., Yong, Q.C., Pan, T.T., Feng, Z.N., Ali, M.Y., Zhou, S., Moore, P.K. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  39. The actions of hydrogen sulfide on dorsal raphe serotonergic neurons in vitro. Kombian, S.B., Reiffenstein, R.J., Colmers, W.F. J. Neurophysiol. (1993) [Pubmed]
  40. Effect of biologically produced sulfur on gas absorption in a biotechnological hydrogen sulfide removal process. Kleinjan, W.E., Lammers, J.N., de Keizer, A., Janssen, A.J. Biotechnol. Bioeng. (2006) [Pubmed]
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