The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SRD5A1  -  steroid-5-alpha-reductase, alpha...

Homo sapiens

Synonyms: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, S5AR 1, SR type 1, Steroid 5-alpha-reductase 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SRD5A1


Psychiatry related information on SRD5A1

  • RESULTS: (1) Reaction time (RT) depended on the SR type, indicating SR-specific differences in processing, which did not vary with age [6].

High impact information on SRD5A1


Chemical compound and disease context of SRD5A1


Biological context of SRD5A1

  • Genetic linkage to the steroid 5alpha-reductase type 1 gene (SRD5A1) was ruled out in this family [14].
  • We conducted genetic association studies of the 5alpha-reductase enzyme genes (SRD5A1 on chromosome 5 and SRD5A2 on chromosome 2) using dimorphic intragenic restriction fragment length polymorphisms [15].
  • CONCLUSION: These results suggest that polymorphisms of SRD5A1 and SRD5A2 genes may not be directly associated with the development of baldness or generation of different clinical phenotypes [1].
  • Our results imply that these sequences may be either coding parts of yet unknown, active SRD5A1 genes, and/or of previously unidentified pseudogenes [16].
  • Our research provide the first evidence for the existence of two new SRD5A1 related, previously unidentified sequences in the human genome [16].

Anatomical context of SRD5A1


Associations of SRD5A1 with chemical compounds

  • RESULTS: The sequence analysis of exon 3 of the SRD5A1 gene indicated an adenine-to-guanine change (ACA vs. ACG), both triplets encoding the amino acid residue threonine [2].
  • In contrast, daily oral treatment with even a low 1 mg/kg/d dose of the dual SRD5A1 and SRD5A2 inhibitor, dutasteride, reduces both normal prostate and H tumor DHT content and weight in intact rats while elevating tissue testosterone [3].
  • SRD5A1 expression was increased in the presence of 5alpha-DHT although no consistent changes were observed when the cells were treated with testosterone [17].
  • Other steroids, including dexamethasone, progesterone, and 6-hydroxypregnanolone, produced no effects on expression of either HSD17B1 or SRD5A1 [17].
  • These results suggest that functional genetic variants might exist in or around SRD5A1 that affect the activity of the 5alpha-reductase enzyme type 1 and influence androgen levels [22].

Other interactions of SRD5A1

  • In contrast, AKR1C3, which shares 84% sequence identity, and 5alpha-reductase type I (SRD5A1) were minimally affected [23].
  • We investigated 10 patients with elevated T/DHT ratios in whom mutations in the SRD5A2 and AR genes had been excluded to find out whether structural alterations of the SRD5A1 gene could contribute to their genital malformations [2].
  • Treatment with 10 or 50 microM forskolin resulted in a 20-60% reduction of expression for HSD17B1 (encoding 17beta-HSD I) in T and B lymphoid cell lines and peripheral blood mononuclear cells, although such a change was not observed in the expression of SRD5A1 (encoding 5alpha-reductase I) [17].
  • In contrast to P-450 3 and steroid 5 alpha-reductase, however, the elevation of P-450j protein was transient and was not accompanied by an increase in P-450j-associated hepatic microsomal aniline hydroxylase activity [24].
  • Single-stranded conformation polymorphism analysis (SSCP) and DNA sequencing were performed after polymerase chain reaction amplification of each of the 5 exons of the SRD5A1 gene in both hyperandrogenic and control group (16 participants) [25].

Analytical, diagnostic and therapeutic context of SRD5A1


  1. Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. Ha, S.J., Kim, J.S., Myung, J.W., Lee, H.J., Kim, J.W. J. Dermatol. Sci. (2003) [Pubmed]
  2. Steroid 5alpha-reductase 1 polymorphisms and testosterone/dihydrotestosterone ratio in male patients with hypospadias. Tria, A., Hiort, O., Sinnecker, G.H. Horm. Res. (2004) [Pubmed]
  3. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Xu, Y., Dalrymple, S.L., Becker, R.E., Denmeade, S.R., Isaacs, J.T. Clin. Cancer Res. (2006) [Pubmed]
  4. The use of alpha-adrenoceptor antagonists in the pharmacological management of benign prostatic hypertrophy: an overview. Hieble, J.P., Ruffolo, R.R. Pharmacol. Res. (1996) [Pubmed]
  5. Variants in the 5{alpha}-Reductase Type 1 and Type 2 Genes Are Associated with Polycystic Ovary Syndrome and the Severity of Hirsutism in Affected Women. Goodarzi, M.O., Shah, N.A., Antoine, H.J., Pall, M., Guo, X., Azziz, R. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  6. Motor-response generation as a source of aging-related behavioural slowing in choice-reaction tasks. Kolev, V., Falkenstein, M., Yordanova, J. Neurobiol. Aging (2006) [Pubmed]
  7. Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism. Andersson, S., Berman, D.M., Jenkins, E.P., Russell, D.W. Nature (1991) [Pubmed]
  8. Steroid 5 alpha-reductase 2 deficiency. Wilson, J.D., Griffin, J.E., Russell, D.W. Endocr. Rev. (1993) [Pubmed]
  9. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. Thigpen, A.E., Silver, R.I., Guileyardo, J.M., Casey, M.L., McConnell, J.D., Russell, D.W. J. Clin. Invest. (1993) [Pubmed]
  10. Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase. Jenkins, E.P., Andersson, S., Imperato-McGinley, J., Wilson, J.D., Russell, D.W. J. Clin. Invest. (1992) [Pubmed]
  11. Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Levy, M.A., Brandt, M., Sheedy, K.M., Dinh, J.T., Holt, D.A., Garrison, L.M., Bergsma, D.J., Metcalf, B.W. J. Steroid Biochem. Mol. Biol. (1994) [Pubmed]
  12. Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer. Salam, M.T., Ursin, G., Skinner, E.C., Dessissa, T., Reichardt, J.K. Urol. Oncol. (2005) [Pubmed]
  13. Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y4 and human clinical isolate PO 1021-7. Masoud, H., Weintraub, S.T., Wang, R., Cotter, R., Holt, S.C. Eur. J. Biochem. (1991) [Pubmed]
  14. Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings. Martin, R.M., Lin, C.J., Nishi, M.Y., Billerbeck, A.E., Latronico, A.C., Russell, D.W., Mendonca, B.B. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  15. Genetic analysis of male pattern baldness and the 5alpha-reductase genes. Ellis, J.A., Stebbing, M., Harrap, S.B. J. Invest. Dermatol. (1998) [Pubmed]
  16. New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8. Eminović, I., Liović, M., Prezelj, J., Kocijancic, A., Rozman, D., Komel, R. Pflugers Arch. (2001) [Pubmed]
  17. Regulation of HSD17B1 and SRD5A1 in lymphocytes. Zhou, Z., Speiser, P.W. Mol. Genet. Metab. (1999) [Pubmed]
  18. Immunohistochemical localization of steroid 5 alpha-reductase 2 in the human male fetal reproductive tract and adult prostate. Levine, A.C., Wang, J.P., Ren, M., Eliashvili, E., Russell, D.W., Kirschenbaum, A. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  19. Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Jenkins, E.P., Hsieh, C.L., Milatovich, A., Normington, K., Berman, D.M., Francke, U., Russell, D.W. Genomics (1991) [Pubmed]
  20. Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2). Anwar, R., Gilbey, S.G., New, J.P., Markham, A.F. MP, Mol. Pathol. (1997) [Pubmed]
  21. An ultrastructural study of the neural circuit between the prefrontal cortex and the mediodorsal nucleus of the thalamus. Kuroda, M., Yokofujita, J., Murakami, K. Prog. Neurobiol. (1998) [Pubmed]
  22. Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1. Ellis, J.A., Panagiotopoulos, S., Akdeniz, A., Jerums, G., Harrap, S.B. J. Hum. Genet. (2005) [Pubmed]
  23. Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling. Ji, Q., Aoyama, C., Nien, Y.D., Liu, P.I., Chen, P.K., Chang, L., Stanczyk, F.Z., Stolz, A. Cancer Res. (2004) [Pubmed]
  24. Mechanisms of cyclophosphamide action on hepatic P-450 expression. LeBlanc, G.A., Waxman, D.J. Cancer Res. (1990) [Pubmed]
  25. Gene analysis of steroid 5 alpha-reductase 1 in hyperandrogenic women. Eminović, I., Komel, R., Prezelj, J., Karamehić, J., Gavrankapetanović, F., Heljić, B. Croat. Med. J. (2005) [Pubmed]
  26. Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II. Makridakis, N.M., di Salle, E., Reichardt, J.K. Pharmacogenetics (2000) [Pubmed]
  27. Genetic linkage mapping of the human steroid 5 alpha-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23-->p22. Morissette, J., Durocher, F., Leblanc, J.F., Normand, T., Labrie, F., Simard, J. Cytogenet. Cell Genet. (1996) [Pubmed]
  28. Disposition and pharmacokinetics of [14C]finasteride after oral administration in humans. Carlin, J.R., Höglund, P., Eriksson, L.O., Christofalo, P., Gregoire, S.L., Taylor, A.M., Andersson, K.E. Drug Metab. Dispos. (1992) [Pubmed]
  29. Inhibition of steroid 5 alpha-reductase activity by aliphatic fatty acids. Candidates for chemoprevention of prostate cancer. Niederprüm, H.J., Schweikert, H.U., Thüroff, J.W., Zänker, K.S. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
WikiGenes - Universities