Disease relevance of Fibrocartilage

• Calcium pyrophosphate dihydrate deposition in lumbar disc fibrocartilage [1].
• SUMMARY OF BACKGROUND DATA: Intravenously administered gadopentetate diffuses similarly into the fibrocartilage of intervertebral discs and herniated disc fragments [2].
• Abnormal endoscopic findings (fibrillation of the deep digital flexor tendon, a defect in the navicular bone fibrocartilage, and synovial hyperplasia) were identified in 3 limbs (2 with an RS of 1, and 1 with an RS of 3) [3].

High impact information on Fibrocartilage

• In the control cases, the BMPRs and ActRs were only weakly expressed in the fibrocartilage tissue at the site of ligament attachments to bone and OP-1/BMP-7 was not detected [4].
• TGF beta 1 stimulates PPi elaboration from hyaline cartilage, fibrocartilage, and ligament, indicating that there is in situ CPPD crystal formation in these tissues [5].
• Meniscal fibrocartilage, the most common site of calcium pyrophosphate deposits, also elaborate PPi [6].
• Relaxin administration significantly increased the length (140 +/- 6%) and weight (170 +/- 9%) of the interpubic fibrocartilage in estrogen-primed rats (n = 15) [7].
• We observed a strong endostatin/collagen XVIII production in articular and fibrocartilage and an inhibitory potency concerning the VEGF-signalling pathway [8].

Biological context of Fibrocartilage

• Chondroitin 6 sulphate and type II collagen are the most consistent markers of the fibrocartilage phenotype and most of the chondroitin 6 sulphate is probably associated with aggrecan [9].
• The purpose of this study was to elucidate the expression of proto-oncogene Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) in fibrocartilage of the disc and hyaline cartilage of the condyle in the rabbit craniomandibular joint (CMJ) [10].

Anatomical context of Fibrocartilage

• Effects of chondroitinase-ABC on proteoglycans and swelling properties of fibrocartilage in bovine flexor tendon [11].
• Our data suggest that MMP-2 plays an important role in fibrocartilage degradation in internal derangement of the temporomandibular joint [12].
• Osteocalcin immunoreactivity concentrated in the extracellular matrix of areas of newly formed bone tissue, i.e. in the subperiosteal and subchondral regions, osteoid tissue and mineralized fibrocartilage zone of the osteotendinous junction [13].
• All fibrocartilage regions, in at least some specimens, labelled for type II collagen, chondroitin 6 sulphate, aggrecan and link protein, molecules more typically associated with articular cartilage [14].
• Blood vessels are usually absent in fibrocartilage, as was shown with a polyclonal antibody against the basement membrane component laminine [15].

Associations of Fibrocartilage with chemical compounds

• Fibrocartilage was suggested by histological appearance, hypocellularity, and a higher hydroxyproline content [16].
• The present study was undertaken to look for more subtle evidence of thermal alteration of human fibrocartilage treated with CO2 laser irradiation [17].
• Further analyses have shown that a large CS-bearing proteoglycan is found in the fibrocartilage [18].
• The selective changes in large proteoglycan and biglycan synthesis, and in the sulfate composition and size of the glycosminoglycan chains, are consistent with what might be expected during development of fibrocartilage in vivo [19].
• The superior fixation of unstable HA implants compared with unstable Ti implants may be ascribed to the presence of fibrocartilage, a higher collagen concentration, and radiating orientation of collagen fibers in the membrane [20].

Gene context of Fibrocartilage

• Gelatinase A was only weakly expressed in the fibrocartilage adjacent to areas of endochondral ossification [21].
• Detection of GFAP in vertebral fibrocartilage in human fetal and newborn tissue [22].
• In ligament tissues, BMP-2 mRNA was present in the chondrocyte-like cells in the fibrocartilage zone [23].
• An immunohistochemical study of the rabbit suprapatella, a sesamoid fibrocartilage in the quadriceps tendon containing aggrecan [24].
• However, the cells in the fibrocartilage of adult tendon displayed a high level of expression for types I and II collagen, decorin, biglycan, and aggrecan [25].

Analytical, diagnostic and therapeutic context of Fibrocartilage

• Electron microscopy of CO2-laser-induced effects in human fibrocartilage [17].
• PCR failed to detect ER mRNA in total RNA extracts from tendon and fibrocartilage [26].

References