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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Fibrocartilage


High impact information on Fibrocartilage

  • In the control cases, the BMPRs and ActRs were only weakly expressed in the fibrocartilage tissue at the site of ligament attachments to bone and OP-1/BMP-7 was not detected [4].
  • TGF beta 1 stimulates PPi elaboration from hyaline cartilage, fibrocartilage, and ligament, indicating that there is in situ CPPD crystal formation in these tissues [5].
  • Meniscal fibrocartilage, the most common site of calcium pyrophosphate deposits, also elaborate PPi [6].
  • Relaxin administration significantly increased the length (140 +/- 6%) and weight (170 +/- 9%) of the interpubic fibrocartilage in estrogen-primed rats (n = 15) [7].
  • We observed a strong endostatin/collagen XVIII production in articular and fibrocartilage and an inhibitory potency concerning the VEGF-signalling pathway [8].

Biological context of Fibrocartilage

  • Chondroitin 6 sulphate and type II collagen are the most consistent markers of the fibrocartilage phenotype and most of the chondroitin 6 sulphate is probably associated with aggrecan [9].
  • The purpose of this study was to elucidate the expression of proto-oncogene Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) in fibrocartilage of the disc and hyaline cartilage of the condyle in the rabbit craniomandibular joint (CMJ) [10].

Anatomical context of Fibrocartilage


Associations of Fibrocartilage with chemical compounds

  • Fibrocartilage was suggested by histological appearance, hypocellularity, and a higher hydroxyproline content [16].
  • The present study was undertaken to look for more subtle evidence of thermal alteration of human fibrocartilage treated with CO2 laser irradiation [17].
  • Further analyses have shown that a large CS-bearing proteoglycan is found in the fibrocartilage [18].
  • The selective changes in large proteoglycan and biglycan synthesis, and in the sulfate composition and size of the glycosminoglycan chains, are consistent with what might be expected during development of fibrocartilage in vivo [19].
  • The superior fixation of unstable HA implants compared with unstable Ti implants may be ascribed to the presence of fibrocartilage, a higher collagen concentration, and radiating orientation of collagen fibers in the membrane [20].

Gene context of Fibrocartilage


Analytical, diagnostic and therapeutic context of Fibrocartilage


  1. Calcium pyrophosphate dihydrate deposition in lumbar disc fibrocartilage. Ellman, M.H., Vazques, L.T., Brown, N.L., Mandel, N. J. Rheumatol. (1981) [Pubmed]
  2. Effect of molecular weight on the diffusion of contrast media into cartilage. Perlewitz, T.J., Haughton, V.M., Riley, L.H., Nguyen-Minh, C., George, V. Spine. (1997) [Pubmed]
  3. Podotrochlear bursa endoscopy in the horse: a cadaver study. Cruz, A.M., Pharr, J.W., Bailey, J.V., Barber, S.M., Fretz, P.B. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2001) [Pubmed]
  4. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Yonemori, K., Imamura, T., Ishidou, Y., Okano, T., Matsunaga, S., Yoshida, H., Kato, M., Sampath, T.K., Miyazono, K., ten Dijke, P., Sakou, T. Am. J. Pathol. (1997) [Pubmed]
  5. A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. Rosenthal, A.K., McCarty, B.A., Cheung, H.S., Ryan, L.M. Arthritis Rheum. (1993) [Pubmed]
  6. Release of pyrophosphate by normal mammalian articular hyaline and fibrocartilage in organ culture. Ryan, L.M., Cheung, H.S., McCarty, D.J. Arthritis Rheum. (1981) [Pubmed]
  7. The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: the influence of estrogen and progesterone in regulating relaxin activity. Samuel, C.S., Butkus, A., Coghlan, J.P., Bateman, J.F. Endocrinology (1996) [Pubmed]
  8. Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage. Pufe, T., Petersen, W.J., Miosge, N., Goldring, M.B., Mentlein, R., Varoga, D.J., Tillmann, B.N. Matrix Biol. (2004) [Pubmed]
  9. Fibrocartilage in the extensor tendons of the human metacarpophalangeal joints. Milz, S., Putz, R., Ralphs, J.R., Benjamin, M. Anat. Rec. (1999) [Pubmed]
  10. Immunohistochemical analysis of Bcl-2 and Bax oncoproteins in rabbit craniomandibular joint. Huang, Q., Singh, B., Sharawy, M. Arch. Oral Biol. (2004) [Pubmed]
  11. Effects of chondroitinase-ABC on proteoglycans and swelling properties of fibrocartilage in bovine flexor tendon. Koob, T.J. J. Orthop. Res. (1989) [Pubmed]
  12. Expression of matrix metalloproteinase-2 in osteoarthritic fibrocartilage from human mandibular condyle. Tanaka, A., Kawashiri, S., Kumagai, S., Takatsuka, S., Narinobou, M., Nakagawa, K., Tanaka, S. J. Oral Pathol. Med. (2000) [Pubmed]
  13. Location and distribution of non-collagenous matrix proteins in musculoskeletal tissues of rat. Kannus, P., Jozsa, L., Järvinen, T.A., Järvinen, T.L., Kvist, M., Natri, A., Järvinen, M. Histochem. J. (1998) [Pubmed]
  14. Fibrocartilage in the transverse ligament of the human acetabulum. Milz, S., Valassis, G., Büttner, A., Maier, M., Putz, R., Ralphs, J.R., Benjamin, M. J. Anat. (2001) [Pubmed]
  15. The distal tendon of the biceps brachii. Structure and clinical correlations. Koch, S., Tillmann, B. Ann. Anat. (1995) [Pubmed]
  16. Preliminary observations of chondral abrasion in a canine model. Altman, R.D., Kates, J., Chun, L.E., Dean, D.D., Eyre, D. Ann. Rheum. Dis. (1992) [Pubmed]
  17. Electron microscopy of CO2-laser-induced effects in human fibrocartilage. Whipple, T.L., Marotta, J.J., May, T.C., Caspari, R.B., Meyers, J.F. Lasers in surgery and medicine. (1987) [Pubmed]
  18. Structure and proteoglycan composition of specialized regions of the elastic tendon of the chicken wing. Carvalho, H.F., Felisbino, S.L., Covizi, D.Z., Della Colleta, H.H., Gomes, L. Cell Tissue Res. (2000) [Pubmed]
  19. Proteoglycan synthesis in fetal tendon is differentially regulated by cyclic compression in vitro. Evanko, S.P., Vogel, K.G. Arch. Biochem. Biophys. (1993) [Pubmed]
  20. Hydroxyapatite coating modifies implant membrane formation. Controlled micromotion studied in dogs. Søballe, K., Brockstedt-Rasmussen, H., Hansen, E.S., Bünger, C. Acta orthopaedica Scandinavica. (1992) [Pubmed]
  21. Distribution of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic bone. Bord, S., Horner, A., Hembry, R.M., Reynolds, J.J., Compston, J.E. J. Anat. (1997) [Pubmed]
  22. Detection of GFAP in vertebral fibrocartilage in human fetal and newborn tissue. Kasper, M., Stosiek, P. Acta Histochem. (1990) [Pubmed]
  23. Involvement of bone morphogenic protein-2 (BMP-2) in the pathological ossification process of the spinal ligament. Tanaka, H., Nagai, E., Murata, H., Tsubone, T., Shirakura, Y., Sugiyama, T., Taguchi, T., Kawai, S. Rheumatology (Oxford, England) (2001) [Pubmed]
  24. An immunohistochemical study of the rabbit suprapatella, a sesamoid fibrocartilage in the quadriceps tendon containing aggrecan. Tischer, T., Milz, S., Maier, M., Schieker, M., Benjamin, M. J. Histochem. Cytochem. (2002) [Pubmed]
  25. In situ expression of collagen and proteoglycan genes during development of fibrocartilage in bovine deep flexor tendon. Perez-Castro, A.V., Vogel, K.G. J. Orthop. Res. (1999) [Pubmed]
  26. Estrogen receptor mRNA expression in callus during fracture healing in the rat. Boden, S.D., Joyce, M.E., Oliver, B., Heydemann, A., Bolander, M.E. Calcif. Tissue Int. (1989) [Pubmed]
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