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MeSH Review

Intervertebral Disk Displacement

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Disease relevance of Intervertebral Disk Displacement


High impact information on Intervertebral Disk Displacement


Chemical compound and disease context of Intervertebral Disk Displacement

  • Eighteen patients had previously been operated on for herniated discs; seven of these (39%) had pyrophosphate deposits in their disc tissue, often in close topographical relation to amyloid [8].
  • Three patients with cervical radicular symptoms and normal metrizamide myelograms underwent thin-section high-resolution computed tomographic scanning because of a strong clinical suspicion of herniated disk [10].
  • Biologically active substances, such as prostaglandins, thromboxanes, and leukotrienes, which are metabolites involved in the arachidonic acid cascade, are detected in herniated disc samples obtained from patients with lumbar disc herniation [11].
  • There is no previous report on the evaluation of gadolinium enhancement characteristics in dogs with concurrent herniated disc and scar [12].
  • Similarly, the levels of nitric oxide, prostaglandin E2, and interleukin-6 were significantly higher in the herniated discs compared with the control discs [13].

Biological context of Intervertebral Disk Displacement

  • Although the mechanical and positional stresses of pregnancy are the primary inciting factors contributing to lumbosacral pain accompanying gestation, in approximately 1:10,000 cases a herniated disk (HNP) can be identified as the proximal cause of pain [14].
  • The herniated discs were examined by gross appearance and histology and production of tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 was investigated [15].

Anatomical context of Intervertebral Disk Displacement


Gene context of Intervertebral Disk Displacement


Analytical, diagnostic and therapeutic context of Intervertebral Disk Displacement


  1. Effects of epidural steroid injection on pain due to lumbar spinal stenosis or herniated disks: a prospective study. Rivest, C., Katz, J.N., Ferrante, F.M., Jamison, R.N. Arthritis care and research : the official journal of the Arthritis Health Professions Association. (1998) [Pubmed]
  2. Clinical experience with gadolinium contrast agents in spinal MR imaging. Sze, G.K. Journal of computer assisted tomography. (1993) [Pubmed]
  3. Phospholipase A2 activity in herniated lumbar discs. Clinical correlations and inhibition by piroxicam. Piperno, M., Hellio le Graverand, M.P., Reboul, P., Mathieu, P., Tron, A.M., Perrin, G., Peschard, M.J., Richard, M., Vignon, E. Spine. (1997) [Pubmed]
  4. Intrathecal prednisolone therapy in postoperative arachnoiditis following operation of herniated disc. Tkaczuk, H. Acta orthopaedica Scandinavica. (1976) [Pubmed]
  5. Rationale and clinical indications for contrast agents in MR imaging of the brain and spine. Atlas, S.W. Journal of computer assisted tomography. (1993) [Pubmed]
  6. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. Haro, H., Crawford, H.C., Fingleton, B., MacDougall, J.R., Shinomiya, K., Spengler, D.M., Matrisian, L.M. J. Clin. Invest. (2000) [Pubmed]
  7. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. Haro, H., Crawford, H.C., Fingleton, B., Shinomiya, K., Spengler, D.M., Matrisian, L.M. J. Clin. Invest. (2000) [Pubmed]
  8. Amyloid in intervertebral discs: a histopathological investigation of surgical material from 100 consecutive operations on herniated discs. Ladefoged, C., Fedders, O., Petersen, O.F. Ann. Rheum. Dis. (1986) [Pubmed]
  9. Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues--how to facilitate the natural resorption process of herniated discs. Haro, H., Komori, H., Kato, T., Hara, Y., Tagawa, M., Shinomiya, K., Spengler, D.M. J. Orthop. Res. (2005) [Pubmed]
  10. Value of computed tomographic myelography in the recognition of cervical herniated disk. Landman, J.A., Hoffman, J.C., Braun, I.F., Barrow, D.L. AJNR. American journal of neuroradiology. (1984) [Pubmed]
  11. Roles of thromboxane A2 and leukotriene B4 in radicular pain induced by herniated nucleus pulposus. Kawakami, M., Matsumoto, T., Tamaki, T. J. Orthop. Res. (2001) [Pubmed]
  12. Gadolinium-enhancement characteristics of magnetic resonance imaging in distinguishing herniated intervertebral disc versus scar in dogs. An, H.S., Nguyen, C., Haughton, V.M., Ho, K.C., Hasegawa, T. Spine. (1994) [Pubmed]
  13. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Kang, J.D., Georgescu, H.I., McIntyre-Larkin, L., Stefanovic-Racic, M., Donaldson, W.F., Evans, C.H. Spine. (1996) [Pubmed]
  14. The lumbar herniated disk of pregnancy: a report of six cases identified by magnetic resonance imaging. LaBan, M.M., Rapp, N.S., von Oeyen, P., Meerschaert, J.R. Archives of physical medicine and rehabilitation. (1995) [Pubmed]
  15. Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model. Yoshida, M., Nakamura, T., Sei, A., Kikuchi, T., Takagi, K., Matsukawa, A. Spine. (2005) [Pubmed]
  16. A controlled biochemical and immunohistochemical study of human synovial-type (group II) phospholipase A2 and inflammatory cells in macroscopically normal, degenerated, and herniated human lumbar disc tissues. Grönblad, M., Virri, J., Rönkkö, S., Kiviranta, I., Vanharanta, H., Seitsalo, S., Rashbaum, R.F., Guyer, R.D. Spine. (1996) [Pubmed]
  17. Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion. Harrington, J.F., Messier, A.A., Bereiter, D., Barnes, B., Epstein, M.H. Spine. (2000) [Pubmed]
  18. Analysis and prevalence of inflammatory cells in subtypes of lumbar disc herniations under cyclooxygenase-2 inhibitor therapy. Aydin, M.V., Sen, O., Kayaselcuk, F., Bolat, F., Tufan, K., Caner, H., Altinors, N. Neurol. Res. (2005) [Pubmed]
  19. Amyloid deposits of immunohistochemically different classes in the ligamentum flavum in biopsies from patients with herniated discs or lumbar spinal stenosis. Gies, U., Linke, R.P., Schachenmayr, W. Clin. Neuropathol. (1996) [Pubmed]
  20. Vascular endothelial growth factor (VEGF)-induced angiogenesis in herniated disc resorption. Haro, H., Kato, T., Komori, H., Osada, M., Shinomiya, K. J. Orthop. Res. (2002) [Pubmed]
  21. Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc. Burke, J.G., Watson, R.W., McCormack, D., Dowling, F.E., Walsh, M.G., Fitzpatrick, J.M. Spine. (2002) [Pubmed]
  22. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Brisby, H., Olmarker, K., Larsson, K., Nutu, M., Rydevik, B. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. (2002) [Pubmed]
  23. Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption. Doita, M., Kanatani, T., Ozaki, T., Matsui, N., Kurosaka, M., Yoshiya, S. Spine. (2001) [Pubmed]
  24. Metrizamide myelography for disk disease: continuing need for epidural venography. Stephenson, T.F. AJNR. American journal of neuroradiology. (1981) [Pubmed]
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