Disease relevance of Saliva

• The salivas studied came from patients with cystic fibrosis (CF), those with asthma, and heavy and light calculus formers [1].
• Human submandibular-sublingual (HSMSL) and parotid (HPS) salivas were collected and tested for their ability to modulate the replication of HIV-1, using a plaque assay on HeLa/CD4+ cell monolayers [2].
• Haemolymph from the elongate clam, Tridacna maxima (Röding) readily precipitates with H-blood group substances, pneumococcus type XIV polysaccharide, human milk and salivas, and with a number of polysaccharides which contain the O-SS-D-galactopyranosyl-(1-6)-D-galactose structure [3].
• IgD was demonstrable in cord sera (18 of 18), hypogammaglobulinemic sera (15 of 15), amniotic fluids (6 of 6), salivas (8 of 10), normal cerebrospinal fluids (12 of 13) and cerebrospinal fluids from patients with subacute sclerosing panencephalitis (5 of 5) [4].

High impact information on Saliva

• Polymorphic PRPs Pe, PmF, PmS, and Ps were found to be missing from the salivas [5].
• ABP subunits appear to dimerize randomly and a model is presented demonstrating the origin of six ABP dimers in the salivas of AbpaaAbpga/AbpabAbpgb heterozygous mice [6].
• An ELISA was developed to determine the relative quantity of MUC7 in the glandular salivas: mean values of approximately 220, 980, and 100 microg mucin per mL were found in submandibular, sublingual, and palatine saliva, respectively [7].
• Salivas with high adherence scores contained significantly more protein and lactoferrin, and significantly less peroxidase, than salivas with low adherence scores [8].
• By the end of the first year, most salivas contained IgA1 and IgA2 antibody to S. mitis antigens [9].

Biological context of Saliva

• The lectin agglutinated human O type red cells, and the hemagglutination reaction was inhibited by H type 1 and type 2 haptens, N-acetyllactosamine and human salivas from secretor individuals [10].
• The acidic proline-rich proteins (Pr) showing genetic polymorphism were purified from human parotid salivas by gel filtration and ion exchange chromatography [11].

Associations of Saliva with chemical compounds

• Cotinine (mean +/- SEM) was detected in all 26 saliva (392 +/- 74 ng/ml) and 27 urine (4264 +/- 508 ng/mg creatinine; 2566 +/- 364 ng/ml) samples from smoking parents, but in only two of 36 salivas and one of 37 urines from nonsmokers (P less than 0.001) [12].
• Similarly, mean cotinine levels in 30 salivas (4.67 +/- 1.10 ng/ml) and 33 urines (35.5 +/- 8.8 ng/mg creatinine; 25.3 +/- 8.1 ng/ml) from passively exposed children were significantly higher (P less than 0.001) than in fluids of 36 unexposed children [12].
• GDP-fucose: N-acetyl-glucosaminide alpha(1----4)-L-fucosyltransferase was demonstrated to be present in salivas from both group I and group II [13].
• 4. RESULTS: Yeast colonization was found in 78% of the high acetaldehyde-producing salivas, compared with 47% in the low acetaldehyde-producing salivas (p = 0.026) [14].
• METHODS: Medical diagnoses, menopausal status, medication utilization, and 2% citric acid stimulated parotid salivas were collected from 396 women, aged 21 to 96 years, from the Baltimore Longitudinal Study of Aging (National Institute on Aging, National Institutes of Health) over a 17-year span by three investigators [15].

Gene context of Saliva

• The stimulated and unstimulated salivas from aged subjects showed significant reductions in concentrations of both MG1 and MG2, as quantitated in mucin dye-binding units [16].
• High activity of t-PA inhibitor was demonstrated in all parotid salivas, and the mean inhibitory effect on t-PA was 13.2 IU t-PA quenched per millilitre [17].
• Fibrinolytic activity was demonstrated in all salivas but one; it was completely quenched by antibodies against t-PA, but antibodies against urokinase-like plasminogen activator had no effect [18].
• The refined antibodies proved to have a reaction pattern with salivas that is the same as that previously reported for anti-Lec sera [19].
• Parotid salivas are characterized by intensely staining amylase and proline-rich protein bands, but contain minute amounts of cystatins, lysozyme and the extra-parotid glycoprotein [20].

Analytical, diagnostic and therapeutic context of Saliva

• The salivas were analysed for Zn, Cu, Fe, Mn by atomic absorption spectrophotometry and for F with a fluoride-sensitive electrode [21].
• Gland contents of mucin and the concentration of mucin in their salivas were positively correlated for both the isoproterenol (p = 0.01) and the control group (p less than 0.01) [22].
• Solid-phase radioimmunoassay, polyacrylamide gel electrophoresis and thin-layer chromatography were used to compare, identify, and characterize the Lewis antigens from human salivas, using monoclonal antibodies directed to the Lea and Leb determinants [23].
• SDS-PAGE of parotid saliva revealed that a number of proteins, including the basic and acid proline-rich proteins, were altered in the salivas of diabetic animals [24].

References