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Chemical Compound Review

Imunovir     4-acetamidobenzoic acid; 9-[(2R,3R,4S,5R)...

Synonyms: Delimmun, Inosiplex, Isoprinosin, Isoprinosine, Metisoprinol, ...
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Disease relevance of Isoprinosin


Psychiatry related information on Isoprinosin

  • To determine whether there is a critical period of time during the assay when isoprinosine has its effect, the cells were selectively preexposed to drug and/or mitogen for a limited period of time, then cultured [5].

High impact information on Isoprinosin


Chemical compound and disease context of Isoprinosin


Biological context of Isoprinosin


Anatomical context of Isoprinosin

  • Antimeasles antibody was absent in the cerebrospinal fluid (CSF) when measured by conventional immunoassay techniques, there was no clinical response to isoprinosine, and the patient showed a selective absence of CSF antibody response to the matrix protein and only a partial serum antibody response to this measles polypeptide [9].
  • Inosiplex, a stimulating agent for normal human T cells and human leukocytes [19].
  • Finally, inosiplex also increases the percentage of monocytes phagocytizing yeast at a concentration between 50 and 500 microgram/ml [19].
  • Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation [20].
  • The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine, a compound developed for antiviral use and whose therapeutic activity may involve the immune system [20].

Associations of Isoprinosin with other chemical compounds


Gene context of Isoprinosin


Analytical, diagnostic and therapeutic context of Isoprinosin


  1. The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection. The Scandinavian Isoprinosine Study Group. Pedersen, C., Sandström, E., Petersen, C.S., Norkrans, G., Gerstoft, J., Karlsson, A., Christensen, K.C., Håkansson, C., Pehrson, P.O., Nielsen, J.O. N. Engl. J. Med. (1990) [Pubmed]
  2. Inosiplex for SSPE. Chalmers, T.C., Smith, H. Lancet (1982) [Pubmed]
  3. Inosiplex in recurrent herpes simplex infection. Abeles, J.H. Lancet (1982) [Pubmed]
  4. Isoprinosine in treatment of acute viral encephalitis. Buge, A., Rancurel, G., Metzger, J., Picard, A., Lesourd, B., Gardeur, D. Lancet (1979) [Pubmed]
  5. The effect of isoprinosine on the PHA response of monocyte-depleted and undepleted peripheral blood mononuclear cells. Jacobsen, P.L., Greenspan, J.S. Journal of immunopharmacology. (1982) [Pubmed]
  6. Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro. Tsang, K.Y., Fudenberg, H.H., Galbraith, G.M., Donnelly, R.P., Bishop, L.R., Koopmann, W.R. J. Clin. Invest. (1985) [Pubmed]
  7. Isoprinosine in patient with systemic lupus erythematosus. Haidushka, I., Zlatev, S. Lancet (1987) [Pubmed]
  8. Isoprinosine and Imuthiol, two potentially active compounds in patients with AIDS-related complex symptoms. Pompidou, A., Delsaux, M.C., Telvi, L., Mace, B., Coutance, F., Falkenrodt, A., Lang, J.M. Cancer Res. (1985) [Pubmed]
  9. SSPE, measles virus, and the matrix protein: report of a case with unusual immunochemical findings. Mandelbaum, D.E., Hall, W.W., Paneth, N., Wolff, R.R., DeVivo, D.C. Ann. Neurol. (1981) [Pubmed]
  10. Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection. Kovacs, J.A., Powell, F., Voeller, D., Allegra, C.J. Antimicrob. Agents Chemother. (1993) [Pubmed]
  11. Treatment of subacute sclerosing panencephalitis with interferon-alpha, ribavirin, and inosiplex. Solomon, T., Hart, C.A., Vinjamuri, S., Beeching, N.J., Malucci, C., Humphrey, P. J. Child Neurol. (2002) [Pubmed]
  12. Combined treatment with subcutaneous interferon-alpha, oral isoprinosine, and lamivudine for subacute sclerosing panencephalitis. Aydin, O.F., Senbil, N., Kuyucu, N., Gürer, Y.K. J. Child Neurol. (2003) [Pubmed]
  13. Trihexyphenidyl and isoprinosine in the treatment of subacute sclerosing panencephalitis. Nunes, M.L., da Costa, J.C., da Silva, L.F. Pediatric neurology. (1995) [Pubmed]
  14. Combined oral isoprinosine-intraventricular alpha-interferon therapy for subacute sclerosing panencephalitis. Gascon, G., Yamani, S., Crowell, J., Stigsby, B., Nester, M., Kanaan, I., Jallu, A. Brain Dev. (1993) [Pubmed]
  15. Efficacy of acyclovir combined with immunopotentiating agents in the treatment of varicella-zoster. Tanphaichitra, D., Srimuang, S. J. Antimicrob. Chemother. (1987) [Pubmed]
  16. Modulation of T- and B-lymphocyte functions by isoprinosine in homosexual subjects with prodromata and in patients with acquired immune deficiency syndrome (AIDS). Tsang, P.H., Tangnavarad, K., Solomon, S., Bekesi, J.G. J. Clin. Immunol. (1984) [Pubmed]
  17. Methisoprinol enhancement of nucleocytoplasmic transport of putative messenger RNA in rat liver. its relation to host defense against virus infection. Ronsen, B., Gordon, P. Biochem. Pharmacol. (1976) [Pubmed]
  18. Immunomodulation of neutrophil chemotaxis in rheumatoid arthritis using levamisole and methisoprinol. Mazzone, A., Baigura, R., Rossini, S., Ricevuti, G. Clinical therapeutics. (1986) [Pubmed]
  19. Inosiplex, a stimulating agent for normal human T cells and human leukocytes. Wybran, J., Govaerts, A., Appelboom, T. J. Immunol. (1978) [Pubmed]
  20. Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation. Hadden, J.W., Hadden, E.M., Coffey, R.G. Infect. Immun. (1976) [Pubmed]
  21. Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date. Sandström, E.G., Kaplan, J.C. Drugs (1987) [Pubmed]
  22. Number of helper T cells and phytohemagglutinin stimulation correlate in cancer patients. Richner, J., Ambinder, E.P., Hoffmann, K., Feuer, E.J., Bekesi, G. Cancer Immunol. Immunother. (1991) [Pubmed]
  23. Inosiplex: metabolism and excretion of the dimethylaminoisopropanol and p-acetamidobenzoic acid components in rhesus monkeys. Streeter, D.G., Pfadenhauer, E.H. Drug Metab. Dispos. (1984) [Pubmed]
  24. Effects of isoprinosine in animal models of depressed T-cell function. Binderup, L. Int. J. Immunopharmacol. (1985) [Pubmed]
  25. Ability of isoprinosine to restore interleukin-2 production and T cell proliferation in autoimmune mice. Fischbach, M., Talal, N. Clin. Exp. Immunol. (1985) [Pubmed]
  26. Protective effect of isoprinosine in genetically susceptible BALB/c mice infected with Leishmania major. Cillari, E., Dieli, M., Lo Campo, P., Sireci, G., Caffarelli, A., Maltese, E., Millott, S., Milano, S., Liew, F.Y. Immunology (1991) [Pubmed]
  27. Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro. Milano, S., Dieli, M., Millott, S., Miceli, M.D., Maltese, E., Cillari, E. Int. J. Immunopharmacol. (1991) [Pubmed]
  28. Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS). Tsang, K.Y., Donnelly, R.P., Galbraith, G.M., Fudenberg, H.H. Int. J. Immunopharmacol. (1986) [Pubmed]
  29. Inosiplex therapy in subacute sclerosing panencephalitis. A multicentre, non-randomised study in 98 patients. Jones, C.E., Dyken, P.R., Huttenlocher, P.R., Jabbour, J.T., Maxwell, K.W. Lancet (1982) [Pubmed]
  30. Isoprinosine treatment in 18 patients with subacute sclerosing panencephalitis: a controlled study. Haddad, F.S., Risk, W.S. Ann. Neurol. (1980) [Pubmed]
  31. Alopecia areata: pathogenesis and treatment. Mitchell, A.J., Krull, E.A. J. Am. Acad. Dermatol. (1984) [Pubmed]
  32. A randomized double-blind study of inosiplex (isoprinosine) therapy in patients with alopecia totalis. Galbraith, G.M., Thiers, B.H., Jensen, J., Hoehler, F. J. Am. Acad. Dermatol. (1987) [Pubmed]
  33. Isoprinosine restores in vitro T lymphocyte functions of cyclophosphamide immunosuppressed mice. Barasoain, I., Rejas, M.T., Portoles, M.P., Ojeda, G., Rojo, J.M. Int. J. Immunopharmacol. (1987) [Pubmed]
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