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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Adrenergic Fibers

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Disease relevance of Adrenergic Fibers


High impact information on Adrenergic Fibers

  • We describe an early length-dependent dysfunction of sensory small-diameter fibers, prior to dysfunction of sympathetic fibers, with depletion of skin NGF and the sensory neuropeptide substance P [4].
  • In DBH-NGF mice, the sympathetic trunk and nerves growing to peripheral tissues were enlarged and contained an increased number of sympathetic fibers [5].
  • The lack of change in the arteriovenous balance for norepinephrine across the heart, in the face of the lowered uptake for this amine, suggested that the liberation of norepinephrine by cardiac sympathetic fibers was reduced [6].
  • It is concluded that 5-HT is taken up by both serotonergic and adrenergic fibers of the iris-ciliary body [7].
  • However, mutant SHP-2 expression resulted in an overproduction of sympathetic fibers in sympathetic target organs [8].

Biological context of Adrenergic Fibers


Anatomical context of Adrenergic Fibers


Associations of Adrenergic Fibers with chemical compounds

  • These results support the existence of both negative and positive feedback mechanisms on the release of norepinephrine by cardiac sympathetic fibers mediated through presynaptic alpha- and beta-adrenoreceptors, respectively [19].
  • These results are discussed in terms of the hypothesis that carbachol may act on the sympathetic fibers on the pial arteries by a nonmuscarinic mechanism to reduce the liberation of the transmitter [20].
  • We also found that rat lumbar sympathetic fibers projecting to the hindquarter vasculature contain NADPH diaphorase, a marker for NO synthase in paraformaldehyde-perfused tissue.(ABSTRACT TRUNCATED AT 250 WORDS)[21]
  • Although VIP is predominantly a parasympathetic mediator, it seemed to be conveyed by sympathetic fibers, as shown by the marked effect of guanethidine treatment [22].
  • Since, in mice, sympathetic activation appears to induce thyroid hormone secretion by a direct action of norepinephrine released from intrathyroidal sympathetic fibers, the recorded variations are presumed to have functional importance [23].

Gene context of Adrenergic Fibers


Analytical, diagnostic and therapeutic context of Adrenergic Fibers

  • Application of clonidine, an alpha(2)-agonist, (0.1 microM) abolished the expression of c-Fos protein in all preparations (n=5), while denervation of the sympathetic fibers in the lumbar colonic and hypogastric nerves in vivo increased the number of c-Fos-positive neurons (n=5) [29].
  • Chemical and surgical sympathectomy greatly reduced the neuropeptide Y- and catecholamine-containing fibers in the erectile tissue but had no clear effect on the neuropeptide Y fibers around the paraurethral glands; a tissue that is not innervated by adrenergic fibers [30].
  • The accumulation of infused NGF in the trigeminal was assessed using ELISA and sympathetic fibers were localized immunohistochemically with an antibody to tyrosine hydroxylase (TH) [31].
  • In contrast, the electrically evoked sweating rate was higher than that evoked chemically (acetylcholine, or ACh; sweating rate 0.31 vs. 0.21 microl/cm2/min, p<0.01), which might be attributed to an increased effectiveness of synchronized discharge in sympathetic fibers upon electrical stimulation [32].


  1. Results of sympathetic denervation in the canine heart: supersensitivity that may be arrhythmogenic. Inoue, H., Zipes, D.P. Circulation (1987) [Pubmed]
  2. Sympathetic neural blockade by thoracic epidural anesthesia suppresses renin release in response to arterial hypotension. Hopf, H.B., Schlaghecke, R., Peters, J. Anesthesiology (1994) [Pubmed]
  3. Increased apparent norepinephrine release rate in anesthetized DOCA-salt hypertensive rats. Bouvier, M., de Champlain, J. Clinical and experimental hypertension. Part A, Theory and practice. (1985) [Pubmed]
  4. The role of endogenous nerve growth factor in human diabetic neuropathy. Anand, P., Terenghi, G., Warner, G., Kopelman, P., Williams-Chestnut, R.E., Sinicropi, D.V. Nat. Med. (1996) [Pubmed]
  5. Expression of NGF in sympathetic neurons leads to excessive axon outgrowth from ganglia but decreased terminal innervation within tissues. Hoyle, G.W., Mercer, E.H., Palmiter, R.D., Brinster, R.L. Neuron (1993) [Pubmed]
  6. Decreased basal cardiac interstitial norepinephrine release after neuronal uptake inhibition in dogs. Cousineau, D., Goresky, C.A., Rose, C.P. Circ. Res. (1986) [Pubmed]
  7. Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. Tobin, A.B., Unger, W., Osborne, N.N. J. Neurosci. (1988) [Pubmed]
  8. SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons. Chen, B., Hammonds-Odie, L., Perron, J., Masters, B.A., Bixby, J.L. Dev. Biol. (2002) [Pubmed]
  9. Effects of chronic sympathetic stimulation on corneal wound healing. Perez, E., Lopez-Briones, L.G., Gallar, J., Belmonte, C. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  10. Interactive drives from two brain stem premotor nuclei are essential to support rat tail sympathetic activity. Ootsuka, Y., McAllen, R.M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  11. Release of calcitonin gene-related peptide in the pig nasal mucosa by antidromic nerve stimulation and capsaicin. Stjärne, P., Lacroix, J.S., Anggård, A., Lundberg, J.M. Regul. Pept. (1991) [Pubmed]
  12. Blood flow and norepinephrine effects on liver vascular and extravascular volumes. Cousineau, D., Goresky, C.A., Rose, C.P. Am. J. Physiol. (1983) [Pubmed]
  13. Effect of centrally administered glucagon on blood lipids in anesthetised dogs. Agarwala, G.C., Mishra, R., Jaiswal, G., Bapat, V. Indian J. Physiol. Pharmacol. (1986) [Pubmed]
  14. Presynaptic and postsynaptic effects of neuropeptide Y in the rat pineal gland. Simonneaux, V., Ouichou, A., Craft, C., Pévet, P. J. Neurochem. (1994) [Pubmed]
  15. Posthatch day/night differences in synaptic ribbon populations of the chick pineal. Robertson, G.N., Dickson, D.H., Jackson, P.C. J. Pineal Res. (1990) [Pubmed]
  16. Adrenergic innervation of the rat nucleus locus coeruleus arises predominantly from the C1 adrenergic cell group in the rostral medulla. Pieribone, V.A., Aston-Jones, G. Neuroscience (1991) [Pubmed]
  17. Nerve growth factor-induced growth of sympathetic axons into the optic tract of mature mice is enhanced by an absence of p75NTR expression. Hannila, S.S., Kawaja, M.D. J. Neurobiol. (1999) [Pubmed]
  18. Innervation of footpads of normal and mutant mice lacking sweat glands. Rao, M.S., Jaszczak, E., Landis, S.C. J. Comp. Neurol. (1994) [Pubmed]
  19. Regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic alpha- and beta-receptors. Yamaguchi, N., de Champlain, J., Nadeau, R.A. Circ. Res. (1977) [Pubmed]
  20. Inhibition of the pial artery constriction induced by sympathetic stimulation by local microapplication of a cholinomimetic agent. Sercombe, R., Wahl, M. J. Cereb. Blood Flow Metab. (1982) [Pubmed]
  21. Nitrosyl factors mediate active neurogenic hindquarter vasodilation in the conscious rat. Davisson, R.L., Johnson, A.K., Lewis, S.J. Hypertension (1994) [Pubmed]
  22. Chemical sympathectomy-induced changes in TH-, VIP-, and CGRP-immunoreactive fibers in the rat mandible periosteum: influence on bone resorption. Cherruau, M., Morvan, F.O., Schirar, A., Saffar, J.L. J. Cell. Physiol. (2003) [Pubmed]
  23. Sympathetic innervation of the thyroid: variation with species and with age. Melander, A., Sundler, F., Westgren, U. Endocrinology (1975) [Pubmed]
  24. Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms. Grundemar, L., Håkanson, R. Gen. Pharmacol. (1993) [Pubmed]
  25. An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals. Karanth, S.S., Springall, D.R., Kuhn, D.M., Levene, M.M., Polak, J.M. Am. J. Anat. (1991) [Pubmed]
  26. Enhanced neurotrophin-induced axon growth in myelinated portions of the CNS in mice lacking the p75 neurotrophin receptor. Walsh, G.S., Krol, K.M., Crutcher, K.A., Kawaja, M.D. J. Neurosci. (1999) [Pubmed]
  27. Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor. Hoyle, G.W., Graham, R.M., Finkelstein, J.B., Nguyen, K.P., Gozal, D., Friedman, M. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  28. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Mach, D.B., Rogers, S.D., Sabino, M.C., Luger, N.M., Schwei, M.J., Pomonis, J.D., Keyser, C.P., Clohisy, D.R., Adams, D.J., O'Leary, P., Mantyh, P.W. Neuroscience (2002) [Pubmed]
  29. Effects of extrinsic autonomic inputs on expression of c-Fos immunoreactivity in myenteric neurons of the guinea pig distal colon. Yuyama, N., Mizuno, J., Tsuzuki, H., Wada-Takahashi, S., Takahashi, O., Tamura, K. Brain Res. (2002) [Pubmed]
  30. Distribution and origin of neuropeptide Y-immunoreactive fibers in the penis of the rat. Carrillo, Y., Fernandez, E., Dail, W.G., Walton, G. Cell Tissue Res. (1991) [Pubmed]
  31. Sympathetic ingrowth to the trigeminal ganglion following intracerebroventricular infusion of nerve growth factor. Shoemaker, S.E., Kudwa, A.E., Isaacson, L.G. Brain Res. (2002) [Pubmed]
  32. Chemically and electrically induced sweating and flare reaction. Namer, B., Bickel, A., Krämer, H., Birklein, F., Schmelz, M. Autonomic neuroscience : basic & clinical. (2004) [Pubmed]
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