Disease relevance of Hemangioendothelioma

• Hypertension associated with endothelin-secreting malignant hemangioendothelioma [1].
• Hepatocellular carcinomas and hemangioendotheliomas were observed in the livers of rats fed a basal diet containing 0.05, 0.10, or 0.25% quinoline for about 16 to 40 weeks [2].
• Focal GLUT1 immunoreactivity was found in 3 of 12 angiosarcomas, but not in any of 5 hemangioendotheliomas (epithelioid or infantile kaposiform) [3].
• Fli-1 was expressed by 50 of 53 vascular tumors scored (94%), including 20 of 22 angiosarcomas, 11 of 12 hemangioendotheliomas, 7 of 7 hemangiomas, and 12 of 12 Kaposi's sarcomas [4].
• We conclude that prednisone in high doses (2 to 4 mg/kg/day) with the addition of digitalis and diuretics for control of congestive heart failure is an effective treatment regimen for infants with hepatic hemangioendothelioma [5].

High impact information on Hemangioendothelioma

• Substrate deuteration did not significantly affect overall incidence of any other tumor type, however, including hemangioendotheliomas and kidney tumors in both sexes, as well as colon, uterine, ovarian, liver, and lung tumors in females [6].
• Furthermore, the shear stress response region of the KLF2 promoter was specifically immunoprecipitated by antibodies against acetylated histones H3 and H4 in shear-stressed but not static hemangioendothelioma cells [7].
• Angiomotin expression promotes hemangioendothelioma invasion [8].
• Combretastatin A-4 prodrug: a potent inhibitor of malignant hemangioendothelioma cell proliferation [9].
• Kaposiform hemangioendothelioma immunoreacts with vascular endothelial growth factor receptor 3, and partial lymphothelial differentiation of this lesion has been suggested [10].

Chemical compound and disease context of Hemangioendothelioma

• Induction of uterine hemangioendothelioma and lymphoma in (C57BL/6N x C3H/2N)F1 mice by oral administration of azathioprine [11].
• Solitary hepatic infantile hemangioendothelioma: dynamic gadolinium-enhanced MR imaging findings [12].
• Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470 [13].
• Kasabach-Merritt syndrome-associated kaposiform hemangioendothelioma successfully treated with cyclophosphamide, vincristine, and actinomycin D [14].
• We describe the case of a 70-year-old man with unicentric grade 1 epitheloid hemangioendothelioma (EH) of the bone that favourably responded to intravenous pamidronate as a single agent [15].

Anatomical context of Hemangioendothelioma

• Four patients had a giant-cell tumor; two, a low-grade osteogenic sarcoma; one, a hemangioendothelioma; and one, a soft-tissue epithelioid sarcoma with osseous involvement [16].
• An intradural extramedullary spinal cord hemangioendothelioma at T10, T11 recurred twice and was irradiated after the third resection [17].
• High grade hemangioendothelioma of the temporal bone in a child: a case report [18].
• A liver-cell tumour and 2 liver hemangioendotheliomas were observed in 3 males treated with 250 ppm DDT [19].

Gene context of Hemangioendothelioma

• Expression of vWF and vimentin in neoplastic EC suggests that functional differentiation of the tumor tissue occurs in the myxomatous and cavernous parts and may be related to the spontaneous regression of the infantile hemangioendothelioma [20].
• A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation [21].
• Expression of VEGFR-3 is a very sensitive marker of KS, kaposiform, and Dabska-type hemangioendotheliomas, suggesting that all show at least partial lymphatic endothelial differentiation [22].
• Two patients with hemangioendothelioma and elevated plasma vascular endothelial growth factor (VEGF) levels are presented [23].
• The administration of interleukin-2 (IL-2) has recently been reported to be favorable for treating malignant hemangioendothelioma (MHE) [24].

Analytical, diagnostic and therapeutic context of Hemangioendothelioma

• In a chronic study, a single subcutaneous injection of MNNG to newborn mice at a dose of 62, 31, or 3 microgram/g of body weight induced tumors of the lung and hemangioendotheliomas in both sexes, and tumors of the liver in males [25].

References