Disease relevance of Coixol

• 6-MBOA most potently inhibited human immunodeficiency virus-1 reverse transcriptase [1].

High impact information on Coixol

• A naturally occurring compound, 6-methoxybenzoxazolinone (6-MBOA), present in grasses, has been shown to induce sexual maturation in a number of rodent species [2].
• Melatonin significantly influenced testis size in each experiment, but treatment with 6-MBOA had no effect in any of these experimental paradigms, indicating that 6-MBOA does not act as a melatonin agonist in the hamster [3].
• This study resolves the overall chemistry of the 2-benzoxazolinone detoxification pathway, and we hypothesize that biotransformation of the related antimicrobial 6-methoxy-2-benzoxazolinone to produce N-(2-hydroxy-4-methoxyphenyl)malonamic acid also occurs via the same enzymatic modifications [4].
• Three-day exposure to 6-MBOA stimulated uterine growth in short-day, adult females, but did not affect adult females housed in long photoperiods [5].
• In addition, 6-MBOA significantly increases the weight of the ovary and uterus in both peripubertal and mature voles [6].

Biological context of Coixol

• These results show that 6-MBOA has the ability to interact with FSH to stimulate follicular development and increase ovulation [7].
• Effect of 6-methoxybenzoxazolinone on sex ratio and breeding performance in Microtus montanus [8].
• Extended treatment for 6 estrous cycles had no influence on the timing of vaginal cyclicity; despite this, 6-MBOA treatment for 2 cycles caused an increase in ovarian weight resulting from an increase in the number of corpora lutea per ovary [9].
• Other females were fed food without 6-MBOA throughout pregnancy, but received one of the two diets during lactation [10].
• In the present study, the effects of 6-MBOA and photoperiod on estrus induction were examined [11].

Anatomical context of Coixol

• 6-Methoxy-2-benzoxazolinone (6-MBOA) at concentrations greater than 20 microM stimulates serotonin N-acetyltransferase (NAT) activity of rat pineal glands in 48-hr organ culture as well as of glands freshly cultured, indicating that 6-MBOA acts postsynaptically [12].
• There was not a significant effect of intravenous injections of 6-MBOA on the ovarian follicles during the transition between the anovulatory and ovulatory seasons in mares [13].
• 3. 6-Methoxy-2-benzoxazolinone treatment also resulted in an increased incidence of abnormal morphogenesis of various organ primordia, including abnormal yolk sac circulation, twisting of body axis, absence of forelimb bud and opening of cranial neural tube [14].

Associations of Coixol with other chemical compounds

• A new tetracyclic diterpenoid, scopadulciol [3], together with 6-methoxybenzoxazolinone, glutinol, and acacetin, was isolated from the 70% EtOH extract of Scoparia dulcis collected in Taiwan. Its structure was elucidated to be 6 beta-benzoyl-12-methyl-13-oxo-9(12)a,9(12)b-dihomo-18-podocarpanol on the basis of spectral data [15].
• Oxidation products generated by peroxidase from ferulic acid and 6-methoxybenzoxazolinone caused significant mortality to the leafhoppers within 5 days [16].
• All animals maintained outdoors in the natural photoperiod and temperature conditions had depressed circulating thyroxine (T4) and elevated triiodothyronine (T3) concentrations; neither implants of melatonin nor 6-MBOA affected these thyroid hormone levels [17].

Gene context of Coixol

• Influence of photoperiod and 6-methoxybenzoxazolinone on the reproductive axis of inbred LSH/Ss Lak male hamsters [18].
• Half the pullets in each chamber received a standard layer mash and the other half received the same diet supplemented with 6-MBOA (MB) [19].
• Examination of pineal indoles and 6-methoxy-2-benzoxazolinone for antioxidant and antimicrobial effects [20].
• The brain metabolite of melatonin, N-acetyl-N'-formyl-5-methoxykynurenamine, and the putative natural melatonin analogue, 6-methoxybenzoxazolinone, failed to affect prolactin levels when administered in a similar manner [21].

Analytical, diagnostic and therapeutic context of Coixol

• No significant effect of intraperitoneal injections of 6-MBOA on the weight of uterus or ovaries was found in eight-week-old mice, failing to confirm the results of an earlier report [13].

References