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Chemical Compound Review

CHEMBL109037     2-amino-3-(2,4,5- trihydroxyphenyl)propanoi...

Synonyms: AG-E-56580, CHEBI:20725, H2380_SIGMA, CCG-204721, Lopac0_000633, ...
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Disease relevance of 6-Ohdopa


High impact information on 6-Ohdopa


Chemical compound and disease context of 6-Ohdopa

  • PPLO, a copper amine oxidase (CuAO) with a 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor, differs from most other members of the CuAO enzyme family in having the ability to oxidize the side chain of lysine residues in a polypeptide [10].

Biological context of 6-Ohdopa


Anatomical context of 6-Ohdopa

  • After 6-OHDA, 6-OHDA plus DMI or the high dose of 6-OHDOPA the DA concentration dropped significantly in the amygdala while low-dose 6-OHDOPA resulted in DA increase [5].
  • In 6-month-old rats that were treated on day of birth with 6-OHDOPA (60 mg/kg, i.p.) there was a 32% loss of nerve cell bodies in the locus coeruleus [15].
  • By 13 days there was a further increase in the relative number of fluorescent fibers in the cerebellar cortex of the morphine +6-OHDOPA group, as compared to the group treated with 6-OHDOPA alone [16].
  • Basal content of 2,5-DHBA, the enzymatically formed spin trap product, was 4-fold higher vs. 2,3-DHBA in the neostriatum of untreated rats, while L-DOPA and 6-OHDOPA each reduced formation of 2,5-DHBA [17].

Associations of 6-Ohdopa with other chemical compounds


Gene context of 6-Ohdopa


Analytical, diagnostic and therapeutic context of 6-Ohdopa


  1. In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells. Morrison, M.E., Yagi, M.J., Cohen, G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Evidence for copper and 3,4,6-trihydroxyphenylalanine quinone cofactors in an amine oxidase from the gram-negative bacterium Escherichia coli K-12. Cooper, R.A., Knowles, P.F., Brown, D.E., McGuirl, M.A., Dooley, D.M. Biochem. J. (1992) [Pubmed]
  3. Brain-derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5-trihydroxyphenylalanine-induced injury. Skaper, S.D., Negro, A., Facci, L., Dal Toso, R. J. Neurosci. Res. (1993) [Pubmed]
  4. Opiate-enhanced toxicity and noradrenergic sprouting in rats treated with 6-hydroxydopa. Harston, C.T., Clark, M.B., Hardin, J.C., Kostrzewa, R.M. Eur. J. Pharmacol. (1981) [Pubmed]
  5. Amygdalar noradrenergic and dopaminergic mechanisms in the regulation of hunger and thirst-motivated behavior. Lénárd, L., Hahn, Z. Brain Res. (1982) [Pubmed]
  6. Tyrosine-derived quinone cofactors. Mure, M. Acc. Chem. Res. (2004) [Pubmed]
  7. Investigation of Cu(I)-dependent 2,4,5-trihydroxyphenylalanine quinone biogenesis in Hansenula polymorpha amine oxidase. Samuels, N.M., Klinman, J.P. J. Biol. Chem. (2006) [Pubmed]
  8. The role of 2,4,5-trihydroxyphenylalanine in melanin biosynthesis. Graham, D.G., Jeffs, P.W. J. Biol. Chem. (1977) [Pubmed]
  9. Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli. Chen, Z., Schwartz, B., Williams, N.K., Li, R., Klinman, J.P., Mathews, F.S. Biochemistry (2000) [Pubmed]
  10. The 1.23 A structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link. Duff, A.P., Cohen, A.E., Ellis, P.J., Hilmer, K., Langley, D.B., Dooley, D.M., Freeman, H.C., Guss, J.M. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
  11. Effects of 6-hydroxydopa on noradrenergic neurons in developing rat brain. Kostrzewa, R.M., Garey, R.E. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  12. Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution. Parsons, M.R., Convery, M.A., Wilmot, C.M., Yadav, K.D., Blakeley, V., Corner, A.S., Phillips, S.E., McPherson, M.J., Knowles, P.F. Structure (1995) [Pubmed]
  13. Differential effects of metal ligands on synaptic membrane glutamate binding and uptake systems. Michaelis, E.K., Belieu, R.M., Grubbs, R.D., Michaelis, M.L., Chang, H.H. Neurochem. Res. (1982) [Pubmed]
  14. Catalytic oxidation of 2,4,5-trihydroxyphenylalanine by tyrosinase: identification and evolution of intermediates. Rodríguez-López, J.N., Bañón-Arnao, M., Martinez-Ortiz, F., Tudela, J., Acosta, M., Varón, R., García-Cánovas, F. Biochim. Biophys. Acta (1992) [Pubmed]
  15. Loss of nerve cell bodies in caudal locus coeruleus following treatment of neonates with 6-hydroxydopa. Clark, M.B., King, J.C., Kostrzewa, R.M. Neurosci. Lett. (1979) [Pubmed]
  16. Developmental localization of noradrenergic innervation to the rat cerebellum following neonatal 6-hydroxydopa and morphine treatment. Harston, C.T., Clark, M.B., Hardin, J.C., Kostrzewa, R.M. Dev. Neurosci. (1982) [Pubmed]
  17. Dopaminergic denervation enhances susceptibility to hydroxyl radicals in rat neostriatum. Kostrzewa, R.M., Kostrzewa, J.P., Brus, R. Amino Acids (2000) [Pubmed]
  18. Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast. Dove, J.E., Schwartz, B., Williams, N.K., Klinman, J.P. Biochemistry (2000) [Pubmed]
  19. Relationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast. Schwartz, B., Green, E.L., Sanders-Loehr, J., Klinman, J.P. Biochemistry (1998) [Pubmed]
  20. TRH-induced behavioral arousal in developing rats pretreated with 6-hydroxydopa. Nomura, Y., Oki, K. Pharmacol. Biochem. Behav. (1980) [Pubmed]
  21. Destruction of catecholamine-containing neurons by 6-hydroxydopa, an endogenous amine oxidase cofactor. Kostrzewa, R.M., Brus, R. Amino Acids (1998) [Pubmed]
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