Chemical Compound Review:
TOPA (2S)-2-amino-3-(2,4,5- trihydroxyphenyl)pro...
Synonyms:
L-Hydroxydopa, Hydroxy-L-dopa, Lopac-H-2380, AG-E-68020, CHEMBL1256516, ...
- Selective toxicity of 6-hydroxydopa for melanoma cells. Wick, M.M., Byers, L., Ratliff, J. J. Invest. Dermatol. (1979)
- Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases. Olney, J.W., Zorumski, C.F., Stewart, G.R., Price, M.T., Wang, G.J., Labruyere, J. Exp. Neurol. (1990)
- Opiate-enhanced toxicity and noradrenergic sprouting in rats treated with 6-hydroxydopa. Harston, C.T., Clark, M.B., Hardin, J.C., Kostrzewa, R.M. Eur. J. Pharmacol. (1981)
- Hypersensitivity of cardiac beta-adrenergic receptors after neonatal treatment of rats with 6-hydroxydopa. Nomura, Y., Kajiyama, H., Segawa, T. Eur. J. Pharmacol. (1980)
- Neonatal 6-hydroxydopa, but not DSP-4, elevates brainstem monoamines and impairs inhibitory avoidance learning in developing rats. Cornwell-Jones, C.A., Decker, M.W., Chang, J.W., Cole, B., Goltz, K.M., Tran, T., McGaugh, J.L. Brain Res. (1989)
- Effects of 6-hydroxydopa and 5,6-dihydroxytryptophan treatment on spontaneous motor activity and brain monoamines in mice. Segawa, T., Sakamoto, K., Naitoh, F. Jpn. J. Pharmacol. (1975)
- A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase. Janes, S.M., Mu, D., Wemmer, D., Smith, A.J., Kaur, S., Maltby, D., Burlingame, A.L., Klinman, J.P. Science (1990)
- Skin conductance activity after intraventricular administration of 6-hydroxydopa in rats. Yamamoto, K., Hoshino, T., Takahashi, Y., Kaneko, H., Ozawa, N. Biol. Psychiatry (1991)
- Inhibition of copper amine oxidase by haloamines: a killer product mechanism. Medda, R., Padiglia, A., Pedersen, J.Z., Agrò, A.F., Rotilio, G., Floris, G. Biochemistry (1997)
- Studies on the formation of 6-hydroxydopamine in mouse brain after administration of 2,4,5-trihydroxyphenylalanine (6-hydroxyDOPA). Evans, J.M., Cohen, G. J. Neurochem. (1989)
- Tryptamine as substrate and inhibitor of lentil seedling copper amine oxidase. Medda, R., Padiglia, A., Finazzi Agrò, A., Pedersen, J.Z., Lorrai, A., Floris, G. Eur. J. Biochem. (1997)
- Gangliosides and neurotrophic factors in neurodegenerative diseases: from experimental findings to clinical perspectives. Fusco, M., Vantini, G., Schiavo, N., Zanotti, A., Zanoni, R., Facci, L., Skaper, S.D. Ann. N. Y. Acad. Sci. (1993)
- Differential effect of various 6-hydroxydopa treatments on the development of central and peripheral noradrenergic neurons. Jaim-Etcheverry, G., Zieher, L.M. Eur. J. Pharmacol. (1977)
- The increase of cardiac beta 1-subtype of beta-adrenergic receptors in adult rats following neonatal 6-hydroxydopa treatment. Kajiyama, H., Obara, K., Nomura, Y., Segawa, T. Eur. J. Pharmacol. (1982)
- Short- and long-term effects of graduated doses of DL-6-OH-DOPA upon marsh mice. Bischoff, F., Bryson, G. Res. Commun. Chem. Pathol. Pharmacol. (1979)
- 6-hydroxydopa during development of central adrenergic neurons produces different long-term changes in rat brain noradrenaline. Zieher, L.M., Jaim-Etcheverry, G. Brain Res. (1975)
- Excitotoxins L-beta-oxalyl-amino-alanine (L-BOAA) and 3,4,6-trihydroxyphenylalanine (6-OH-DOPA) inhibit [3H] alpha-amino-3- hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) binding in human hippocampus. Künig, G., Hartmann, J., Niedermeyer, B., Deckert, J., Ransmayr, G., Heinsen, H., Beckmann, H., Riederer, P. Neurosci. Lett. (1994)
- Loss of nerve cell bodies in caudal locus coeruleus following treatment of neonates with 6-hydroxydopa. Clark, M.B., King, J.C., Kostrzewa, R.M. Neurosci. Lett. (1979)
- Parallel changes in brain flunitrazepam binding and density of noradrenergic innervation. Medina, J.H., Novas, M.L. Eur. J. Pharmacol. (1983)
- The relationship of benzodiazepine binding sites to the norepinephrine projection in the hypothalamus of the adult rat. Harary, N., Kellogg, C. Brain Res. (1989)
- Specific detection of quinoproteins by redox-cycling staining. Paz, M.A., Flückiger, R., Boak, A., Kagan, H.M., Gallop, P.M. J. Biol. Chem. (1991)
- An investigation of bovine serum amine oxidase active site stoichiometry: evidence for an aminotransferase mechanism involving two carbonyl cofactors per enzyme dimer. Janes, S.M., Klinman, J.P. Biochemistry (1991)
- Differential effects of metal ligands on synaptic membrane glutamate binding and uptake systems. Michaelis, E.K., Belieu, R.M., Grubbs, R.D., Michaelis, M.L., Chang, H.H. Neurochem. Res. (1982)
- Amine oxidases from Aspergillus niger: identification of a novel flavin-dependent enzyme. Schilling, B., Lerch, K. Biochim. Biophys. Acta (1995)
- Choline acetyltransferase activity increases in the brain stem of rats treated at birth with 6-hydroxydopa. Jaim-Etcheverry, G., Teitelman, G., Zieher, L.M. Brain Res. (1975)
- Production of 6-hydroxydopa by human tyrosinase. Hansson, C., Rorsman, H., Rosengren, E., Wittbjer, A. Acta Derm. Venereol. (1985)
- TRH-induced behavioral arousal in developing rats pretreated with 6-hydroxydopa. Nomura, Y., Oki, K. Pharmacol. Biochem. Behav. (1980)
- Studies on the mechanism of sprouting of noradrenergic terminals in rat and mouse cerebellum after neonatal 6-hydroxydopa. Kostrezewa, R.M., Klara, J.W., Robertson, J., Walker, L.C. Brain Res. Bull. (1978)
- The influence of central chemical sympathectomy and reserpine on peripheral effects of noradrenaline and cyclic AMP dibutyrate injected into the cerebral ventricles. Brus, R., Herman, Z.S., Dzikowski, A., Zabawska, J. Arch. Immunol. Ther. Exp. (Warsz.) (1976)