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Gene Review

Hgf  -  hepatocyte growth factor

Rattus norvegicus

Synonyms: Hepatocyte growth factor, Hepatopoietin-A, SF, Scatter factor
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Disease relevance of Hgf


Psychiatry related information on Hgf

  • HGF treatment may be a potent therapeutic strategy for cerebrovascular diseases, including cerebral infarct and vascular dementia [4].
  • CONCLUSIONS: In prostate epithelial cells, Id 1 may be specifically involved in promoting proliferation whereas Id 4 and Id 2 may have defined roles in regulating differentiated functions in response to androgens and local paracrine factors such as HGF [5].
  • Two weeks after LAD ligation, 3 different treatments were conducted: (1) neonatal rat cardiomyocytes group (10(6) cells, T group, n=11), (2) HVJ-liposomes bearing the hHGF gene group (H group, n=10), and (3) combined (T-H group, n=10) [6].

High impact information on Hgf


Chemical compound and disease context of Hgf


Biological context of Hgf


Anatomical context of Hgf

  • CONCLUSIONS: HGF promotes the growth of preneoplastic hepatocytes but does not affect the growth of liver carcinoma cells in 3'-Me-DAB-treated rats [17].
  • Scatter Factor (SF) is a fibroblast-secreted protein which promotes motility and matrix invasion of epithelial cells [16].
  • SF and HGF cDNA clones from human fibroblasts, placenta and liver had virtually identical sequences [16].
  • These results indicate that HGF/c-Met plays a role in capillary endothelial cell regeneration in the ischemically injured heart [1].
  • Northern blotting revealed that HGF mRNA expression in the heart was augmented threefold at 24 and 48 hours and remained elevated by twofold at 120 hours after the myocardium was reperfused [1].

Associations of Hgf with chemical compounds

  • Tyrosine phosphorylation of c-Met in carcinoma cells was unaffected by HGF administration [17].
  • The rats were given intravenous recombinant human HGF or vehicle, and DNA synthesis was assessed by the 5-bromo-2'-deoxyuridine labeling index [17].
  • Moreover, HGF/SF is an essential component of muscle-derived support for motoneurons, since blocking antibodies to HGF/SF specifically inhibited 65% of the trophic activity of media conditioned by C2/C7 skeletal myotubes, but did not inhibit the trophic activity secreted by Schwann cell lines [18].
  • Cleavage of single chain HGF/SF or HGF/NK1 by factor Xa does not alter the affinity of the respective molecules for heparin, but it did variably affect the associated mitogenic activity of these factors [19].
  • HGF was also detected by reverse transcriptase-polymerase chain reaction in both benign and malignant tissues from radical prostatectomy specimens. c-MET transcripts were identified by Northern blot in two androgen-insensitive human prostatic carcinoma cell lines (DU 145 and PC-3) but not the androgen-sensitive LNCaP cell line [20].

Physical interactions of Hgf


Enzymatic interactions of Hgf


Co-localisations of Hgf

  • Our results confirmed that expression of TGF-beta mRNA co-localized with HGF mRNA expression in the cirrhotic liver [23].

Regulatory relationships of Hgf


Other interactions of Hgf


Analytical, diagnostic and therapeutic context of Hgf


  1. Enhanced expression of hepatocyte growth factor/c-Met by myocardial ischemia and reperfusion in a rat model. Ono, K., Matsumori, A., Shioi, T., Furukawa, Y., Sasayama, S. Circulation (1997) [Pubmed]
  2. Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Price, J.A., Kovach, S.J., Johnson, T., Koniaris, L.G., Cahill, P.A., Sitzmann, J.V., McKillop, I.H. Hepatology (2002) [Pubmed]
  3. Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas. Krasnoselsky, A., Massay, M.J., DeFrances, M.C., Michalopoulos, G., Zarnegar, R., Ratner, N. J. Neurosci. (1994) [Pubmed]
  4. Hepatocyte growth factor improved learning and memory dysfunction of microsphere-embolized rats. Date, I., Takagi, N., Takagi, K., Kago, T., Matsumoto, K., Nakamura, T., Takeo, S. J. Neurosci. Res. (2004) [Pubmed]
  5. Negative acting HLH proteins Id 1, Id 2, Id 3, and Id 4 are expressed in prostate epithelial cells. Chaudhary, J., Schmidt, M., Sadler-Riggleman, I. Prostate (2005) [Pubmed]
  6. Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Miyagawa, S., Sawa, Y., Taketani, S., Kawaguchi, N., Nakamura, T., Matsuura, N., Matsuda, H. Circulation (2002) [Pubmed]
  7. Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Ueki, T., Kaneda, Y., Tsutsui, H., Nakanishi, K., Sawa, Y., Morishita, R., Matsumoto, K., Nakamura, T., Takahashi, H., Okamoto, E., Fujimoto, J. Nat. Med. (1999) [Pubmed]
  8. Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats. Tahara, M., Matsumoto, K., Nukiwa, T., Nakamura, T. J. Clin. Invest. (1999) [Pubmed]
  9. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. Maher, J.J. J. Clin. Invest. (1993) [Pubmed]
  10. Ameliorative effect of hepatocyte growth factor on glycerol-induced acute renal failure with acute tubular necrosis. Nagano, T., Mori-Kudo, I., Tsuchida, A., Kawamura, T., Taiji, M., Noguchi, H. Nephron (2002) [Pubmed]
  11. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Kim, W.H., Matsumoto, K., Bessho, K., Nakamura, T. Am. J. Pathol. (2005) [Pubmed]
  12. Lipopolysaccharide potentiates the effect of hepatocyte growth factor on hepatocyte replication in rats by augmenting AP-1 activity. Gao, C., Jokerst, R., Gondipalli, P., Cai, S.R., Kennedy, S., Flye, M.W., Ponder, K.P. Hepatology (1999) [Pubmed]
  13. Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy. Gao, X., Mae, H., Ayabe, N., Takai, T., Oshima, K., Hattori, M., Ueki, T., Fujimoto, J., Tanizawa, T. Kidney Int. (2002) [Pubmed]
  14. The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced by thioacetamide. Sato, M., Kakubari, M., Kawamura, M., Sugimoto, J., Matsumoto, K., Ishii, T. Biochem. Pharmacol. (2000) [Pubmed]
  15. S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Martínez-Chantar, M.L., Vázquez-Chantada, M., Garnacho, M., Latasa, M.U., Varela-Rey, M., Dotor, J., Santamaria, M., Martínez-Cruz, L.A., Parada, L.A., Lu, S.C., Mato, J.M. Gastroenterology (2006) [Pubmed]
  16. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. Naldini, L., Weidner, K.M., Vigna, E., Gaudino, G., Bardelli, A., Ponzetto, C., Narsimhan, R.P., Hartmann, G., Zarnegar, R., Michalopoulos, G.K. EMBO J. (1991) [Pubmed]
  17. Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells. Ogasawara, H., Hiramoto, J., Takahashi, M., Shirahama, K., Furusaka, A., Hiyane, S., Nakada, T., Nagayama, K., Tanaka, T. Gastroenterology (1998) [Pubmed]
  18. Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons. Yamamoto, Y., Livet, J., Pollock, R.A., Garces, A., Arce, V., deLapeyrière, O., Henderson, C.E. Development (1997) [Pubmed]
  19. Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa. Pediaditakis, P., Monga, S.P., Mars, W.M., Michalopoulos, G.K. J. Biol. Chem. (2002) [Pubmed]
  20. Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Humphrey, P.A., Zhu, X., Zarnegar, R., Swanson, P.E., Ratliff, T.L., Vollmer, R.T., Day, M.L. Am. J. Pathol. (1995) [Pubmed]
  21. Heparin modulates the receptor-binding and mitogenic activity of hepatocyte growth factor on hepatocytes. Naka, D., Ishii, T., Shimomura, T., Hishida, T., Hara, H. Exp. Cell Res. (1993) [Pubmed]
  22. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Mars, W.M., Zarnegar, R., Michalopoulos, G.K. Am. J. Pathol. (1993) [Pubmed]
  23. Expression of hepatocyte growth factor mRNA in rat liver cirrhosis induced by N-nitrosodimethylamine as evidenced by in situ RT-PCR. Hata, J., Ikeda, E., Uno, H., Asano, S. J. Histochem. Cytochem. (2002) [Pubmed]
  24. Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor. Wong, V., Glass, D.J., Arriaga, R., Yancopoulos, G.D., Lindsay, R.M., Conn, G. J. Biol. Chem. (1997) [Pubmed]
  25. Hepatocyte growth factor stimulates the induction of cytokine-induced neutrophil chemoattractant through the activation of NF-kappaB in rat hepatocytes. Kaibori, M., Yanagida, H., Nakanishi, H., Ozaki, T., Yoshida, H., Matsui, K., Hijikawa, T., Kamiyama, Y., Okumura, T. J. Surg. Res. (2006) [Pubmed]
  26. Hepatocyte growth factor activates several transduction pathways in rat pancreatic acini. Aparicio, I.M., Garcia-Marin, L.J., Andreolotti, A.G., Bodega, G., Jensen, R.T., Bragado, M.J. Biochim. Biophys. Acta (2003) [Pubmed]
  27. Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes. Takebayashi, T., Iwamoto, M., Jikko, A., Matsumura, T., Enomoto-Iwamoto, M., Myoukai, F., Koyama, E., Yamaai, T., Matsumoto, K., Nakamura, T. J. Cell Biol. (1995) [Pubmed]
  28. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. Nicosia, R.F., Nicosia, S.V., Smith, M. Am. J. Pathol. (1994) [Pubmed]
  29. TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. Mori, S., Matsuzaki, K., Yoshida, K., Furukawa, F., Tahashi, Y., Yamagata, H., Sekimoto, G., Seki, T., Matsui, H., Nishizawa, M., Fujisawa, J., Okazaki, K. Oncogene (2004) [Pubmed]
  30. 1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Li, Y., Spataro, B.C., Yang, J., Dai, C., Liu, Y. Kidney Int. (2005) [Pubmed]
  31. Hepatocyte-stimulated expression of hepatocyte growth factor (HGF) in cultured rat hepatic stellate cells. Skrtic, S., Wallenius, V., Ekberg, S., Brenzel, A., Gressner, A.M., Jansson, J.O. J. Hepatol. (1999) [Pubmed]
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