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Chemical Compound Review

METHIONINE SULFOXIMINE     2-amino-4- (methylsulfonimidoyl)butanoic acid

Synonyms: CCRIS 5096, AG-E-09256, ALBB-008823, CHEBI:47833, M9503_SIGMA, ...
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High impact information on METHIONINE SULFOXIMINE


Biological context of METHIONINE SULFOXIMINE


Anatomical context of METHIONINE SULFOXIMINE

  • GS was inhibited centrally by perfusing the ventriculocisternal space with artificial cerebrospinal fluid (CSF) containing 92.5 mmol MSO per liter at a fixed pH, perfusion rate, and pressure [10].
  • After culturing in the presence of methionine sulfoximine (MSX), a GS inhibitor, we obtained a MSX-resistant HepG2 subline (GS-HepG2), which had amplified GS gene; ammonia removal activity was estimated to be 1/7 of that of rat primary culture hepatocytes [11].
  • Caco-2 cells were incubated with different concentrations of Gln with or without methionine sulfoximine (MS, an inhibitor of glutamine synthetase) before stimulation with LPS [12].
  • MSO treatment decreased glutamine release from skeletal muscle and plasma glutamine concentration [13].
  • An altered transfer of nutrient molecules from astrocytes to neurons may underlie these effects of MS, although direct effects of MS upon neurons or upon peripheral structures that regulate respiration cannot be completely ruled out as an explanation [14].

Associations of METHIONINE SULFOXIMINE with other chemical compounds



  • The largest amount of IL-8 was secreted by cells in the presence of MS with no Gln in the medium after exposure to LPS [12].
  • Effect of methionine sulfoximine (MSO) on the regional activity of choline acetyltransferase in rat brain [20].


  1. Restoration of cerebrovascular CO2 responsivity by glutamine synthesis inhibition in hyperammonemic rats. Takahashi, H., Koehler, R.C., Hirata, T., Brusilow, S.W., Traystman, R.J. Circ. Res. (1992) [Pubmed]
  2. Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis. Blei, A.T., Olafsson, S., Therrien, G., Butterworth, R.F. Hepatology (1994) [Pubmed]
  3. Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology. Potsic, B., Holliday, N., Lewis, P., Samuelson, D., DeMarco, V., Neu, J. Pediatr. Res. (2002) [Pubmed]
  4. Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells. Rotoli, B.M., Uggeri, J., Dall'Asta, V., Visigalli, R., Barilli, A., Gatti, R., Orlandini, G., Gazzola, G.C., Bussolati, O. Cell. Physiol. Biochem. (2005) [Pubmed]
  5. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Crespo, J.L., Powers, T., Fowler, B., Hall, M.N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis. Master, S., Gottstein, J., Blei, A.T. Hepatology (1999) [Pubmed]
  7. Development of transfection and high-producer screening protocols for the CHOK1SV cell system. de la Cruz Edmonds, M.C., Tellers, M., Chan, C., Salmon, P., Robinson, D.K., Markusen, J. Mol. Biotechnol. (2006) [Pubmed]
  8. Limitations to the development of humanized antibody producing Chinese hamster ovary cells using glutamine synthetase-mediated gene amplification. Jun, S.C., Kim, M.S., Hong, H.J., Lee, G.M. Biotechnol. Prog. (2006) [Pubmed]
  9. Glutamine synthetase: a key enzyme for intestinal epithelial differentiation? Weiss, M.D., DeMarco, V., Strauss, D.M., Samuelson, D.A., Lane, M.E., Neu, J. JPEN. Journal of parenteral and enteral nutrition. (1999) [Pubmed]
  10. Central respiratory effects of glutamine synthesis inhibition in dogs. Hoop, B., Systrom, D.M., Shih, V.E., Kazemi, H. J. Appl. Physiol. (1988) [Pubmed]
  11. Long-term culture of glutamine synthetase-transfected HepG2 cells in circulatory flow bioreactor for development of a bioartificial liver. Enosawa, S., Miyashita, T., Suzuki, S., Li, X.K., Tsunoda, M., Amemiya, H., Yamanaka, M., Hiramatsu, S., Tanimura, N., Omasa, T., Suga, K., Matsumura, T. Cell transplantation. (2000) [Pubmed]
  12. Glutamine decreases lipopolysaccharide-induced IL-8 production in Caco-2 cells through a non-NF-kappaB p50 mechanism. Huang, Y., Li, N., Liboni, K., Neu, J. Cytokine (2003) [Pubmed]
  13. Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis. Safránek, R., Holecek, M., Sispera, L., Muthný, T. Ann. Nutr. Metab. (2006) [Pubmed]
  14. An astrocyte toxin influences the pattern of breathing and the ventilatory response to hypercapnia in neonatal rats. Young, J.K., Dreshaj, I.A., Wilson, C.G., Martin, R.J., Zaidi, S.I., Haxhiu, M.A. Respiratory physiology & neurobiology. (2005) [Pubmed]
  15. Regulation of neurotransmitter aspartate metabolism by glial glutamine synthetase. Rothstein, J.D., Tabakoff, B. J. Neurochem. (1986) [Pubmed]
  16. Glutamine is a powerful effector of heat shock protein expression in Drosophila Kc cells. Sanders, M.M., Kon, C. J. Cell. Physiol. (1991) [Pubmed]
  17. Inhibition of glutamine synthetase in a549 cells during hyperoxia. McGrath-Morrow, S.A., Stahl, J. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  18. Regulation of urea uptake in Pseudomonas aeruginosa. Jahns, T. Antonie Van Leeuwenhoek (1992) [Pubmed]
  19. Kinetic, ESR, and trapping evidence for in vivo binding of Mn(II) to glutamine synthetase in brain cells. Wedler, F.C., Ley, B.W. Neurochem. Res. (1994) [Pubmed]
  20. Effect of methionine sulfoximine (MSO) on the regional activity of choline acetyltransferase in rat brain. Owasoyo, J.O. Zentralblatt für Veterinärmedizin. Reihe A. (1981) [Pubmed]
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