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Chemical Compound Review

Tixocortol     (8R,9R,10R,11S,13S,14S,17R)- 11,17...

Synonyms: Tixocortolum, CHEBI:63560, AC1L4S90, D08610, 61951-99-3, ...
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Disease relevance of Tixocortol


High impact information on Tixocortol


Chemical compound and disease context of Tixocortol


Biological context of Tixocortol


Anatomical context of Tixocortol

  • When administered locally, TP and tixocortol (T) exerted a dose dependent inhibitory activity on exudate volume (ID30 = 12.4 micrograms or 13.1 micrograms/pleural cavity) and leukocyte count (ID30 = 83 or 230 micrograms); in the same conditions [13].

Associations of Tixocortol with other chemical compounds


Gene context of Tixocortol


Analytical, diagnostic and therapeutic context of Tixocortol

  • METHODS: Tixocortol pivalate has been incorporated in our standard 1-52 patch test series since November 1992 [3].
  • There was a significant tixocortol pivalate sensitization of the test animals compared to the control group (p<0.05), after both challenge and re-challenge [18].
  • We report on a patient in whom the misinterpretation of her allergic nasal symptoms to the corticosteroid tixocortol pivalate resulted in hospitalization and considerable medical expenses [19].


  1. Skin reactions to inhaled corticosteroids. Isaksson, M. Drug safety : an international journal of medical toxicology and drug experience. (2001) [Pubmed]
  2. Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study. Friedman, B.S., Metcalfe, D.D. Clin. Exp. Allergy (1991) [Pubmed]
  3. Contact hypersensitivity to tixocortol pivalate. Lutz, M.E., el-Azhary, R.A., Gibson, L.E., Fransway, A.F. J. Am. Acad. Dermatol. (1998) [Pubmed]
  4. Delayed hypersensitivity reactions to corticosteroids applied to mucous membranes. Bircher, A.J., Pelloni, F., Langauer Messmer, S., Müller, D. Br. J. Dermatol. (1996) [Pubmed]
  5. Reactivity of tixocortol pivalate-positive patients in intradermal and oral provocation tests. Räsänen, L., Tuomi, M.L., Ylitalo, L. Br. J. Dermatol. (1996) [Pubmed]
  6. Cutaneous-mucosal allergic contact reaction due to topical corticosteroids. Gonzalo Garijo, M.A., Bobadilla González, P. Allergy (1995) [Pubmed]
  7. Contact hypersensitivity to hydrocortisone-free-alcohol in patients with allergic patch test reactions to tixocortol pivalate. Lauerma, A.I., Tarvainen, K., Forström, L., Reitamo, S. Contact Derm. (1993) [Pubmed]
  8. Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone. Lauerma, A.I. Contact Derm. (1991) [Pubmed]
  9. Efficacy of endonasal neomycin-tixocortol pivalate irrigation in the treatment of chronic allergic and bacterial sinusitis. Cuenant, G., Stipon, J.P., Plante-Longchamp, G., Baudoin, C., Guerrier, Y. ORL J. Otorhinolaryngol. Relat. Spec. (1986) [Pubmed]
  10. A comparison of the effects of tixocortol pivalate (JO 1016), hydrocortisone acetate and beclomethasone dipropionate on the phagocytosis and lysis of microorganisms by alveolar macrophages. Uphill, P.F., Poole, A. Arzneimittel-Forschung. (1981) [Pubmed]
  11. Direct inhibition of cyclooxygenase pathway in platelets by tixocortol 21-pivalate: comparison with related structures, steroidal and non steroidal anti-inflammatory drugs. Lelievre, V., Martin, B., Bure, J., Junien, J.L. Agents Actions (1988) [Pubmed]
  12. Pharmacotherapy of inflammatory bowel disease. Reynolds, P.D., Hunter, J.O. Digestive diseases (Basel, Switzerland) (1993) [Pubmed]
  13. Local anti-inflammatory activities of tixocortol 21-pivalate, inhibition of prostaglandins and leukotrienes synthesis, in carrageenin-induced pleurisy. Reversion of effects by RU 486. Lelievre, V., Martin, B., Junien, J.L., Bure, J. Agents Actions (1988) [Pubmed]
  14. Patch-testing with serial dilutions of tixocortol pivalate and potential cross-reactive substances. Isaksson, M., Bruze, M., Goossens, A., Lepoittevin, J.P. Acta Derm. Venereol. (2000) [Pubmed]
  15. Sensitization studies with mometasone furoate, tixocortol pivalate, and budesonide in the guinea pig. Bruze, M., Bjorkner, B., Dooms-Goossens, A. Contact Derm. (1996) [Pubmed]
  16. A comparison of the inhibitory effects of budesonide, beclomethasone dipropionate, dexamethasone, hydrocortisone and tixocortol pivalate on cytokine release from leukocytes recovered from human bronchoalveolar lavage. Whelan, C.J., Payne, A.N., Planquois, J.M. Inflamm. Res. (1999) [Pubmed]
  17. A comparison of the effects of tixocortol pivalate (JO 1016), hydrocortisone acetate and beclomethasone dipropionate on collagen synthesis and degradation. Uphill, P.F., Daniel, M.R. Arzneimittel-Forschung. (1981) [Pubmed]
  18. Tixocortol pivalate contact allergy in the GPMT: frequency and cross-reactivity. Frankild, S., Lepoittevin, J.P., Kreilgaard, B., Andersen, K.E. Contact Derm. (2001) [Pubmed]
  19. Allergic contact dermatitis from tixocortol pivalate in a nasal spray masquerading as infectious complication of sinusitis. Bircher, A.J., Hirsbrunner, P., Tschopp, K., Wildermuth, V. ORL J. Otorhinolaryngol. Relat. Spec. (1995) [Pubmed]
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