Chemical Compound Review:
Dihydropyridines 5-[[6-[(2-fluorophenyl) methoxy]naphthalen...
Synonyms:
Isaglitazone, Netoglitazone, MCC-555, CHEMBL93747, MCC 555, ...
- RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide. Kumagai, T., Ikezoe, T., Gui, D., O'Kelly, J., Tong, X.J., Cohen, F.J., Said, J.W., Koeffler, H.P. Clin. Cancer Res. (2004)
- Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat. Lazarenko, O.P., Rzonca, S.O., Suva, L.J., Lecka-Czernik, B. Bone (2006)
- A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Yamaguchi, K., Lee, S.H., Eling, T.E., Baek, S.J. Mol. Cancer Ther. (2006)
- A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. Reginato, M.J., Bailey, S.T., Krakow, S.L., Minami, C., Ishii, S., Tanaka, H., Lazar, M.A. J. Biol. Chem. (1998)
- Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation. Ulrich, S., Wächtershäuser, A., Loitsch, S., von Knethen, A., Brüne, B., Stein, J. Exp. Cell Res. (2005)
- The new antidiabetic drug MCC-555 acutely sensitizes insulin signaling in isolated cardiomyocytes. Liu, L.S., Tanaka, H., Ishii, S., Eckel, J. Endocrinology (1998)
- A novel thiazolidinedione MCC-555 down-regulates tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1 in vascular endothelial cells. Kurebayashi, S., Xu, X., Ishii, S., Shiraishi, M., Kouhara, H., Kasayama, S. Atherosclerosis (2005)
- Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat. Pickavance, L.C., Widdowson, P.S., Foster, J.R., Williams, G., Wilding, J.P. International journal of experimental pathology. (2003)
- Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection. Sun, N., Lin, M., Fan, G., Hong, Z., Lu, G. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006)