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Chemical Compound Review

Dihydropyridines     5-[[6-[(2-fluorophenyl) methoxy]naphthalen...

Synonyms: Isaglitazone, Netoglitazone, MCC-555, CHEMBL93747, MCC 555, ...
 
 
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Disease relevance of MCC-555

  • CONCLUSIONS: RWJ-241947 has surprisingly potent antiproliferative effects against prostate cancer cells in vivo, and it enhances the antitumor activity of As2O3 against myeloma cells [1].
  • Some thiazolidinediones have anticancer activity against solid and hematological malignancies; the anticancer potency of RWJ-241947 has not been examined [1].
  • Remarkably, in vivo treatment of male beige/nude/X-linked immunodeficient (BNX) mice with RWJ-241947 profoundly suppressed growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue [1].
  • In vivo, the administration of netoglitazone at an effective hyperglycemic dose (10 microg/g body weight/day) did not result in trabecular bone loss [2].
  • These findings may provide a novel explanation for the antitumorigenic and/or proapoptotic action of MCC-555 in human colorectal cancer and the ability of pharmacologic approaches to be used against diseases caused by alterations of RNA stability [3].
 

High impact information on MCC-555

 

Chemical compound and disease context of MCC-555

 

Biological context of MCC-555

 

Anatomical context of MCC-555

 

Associations of MCC-555 with other chemical compounds

  • In conclusion, MCC-555 rapidly sensitizes insulin-stimulated cardiac glucose uptake by enhancing insulin signaling resulting from increased intrinsic activity of PI 3-kinase [6].
 

Gene context of MCC-555

 

Analytical, diagnostic and therapeutic context of MCC-555

References

  1. RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide. Kumagai, T., Ikezoe, T., Gui, D., O'Kelly, J., Tong, X.J., Cohen, F.J., Said, J.W., Koeffler, H.P. Clin. Cancer Res. (2004) [Pubmed]
  2. Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat. Lazarenko, O.P., Rzonca, S.O., Suva, L.J., Lecka-Czernik, B. Bone (2006) [Pubmed]
  3. A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Yamaguchi, K., Lee, S.H., Eling, T.E., Baek, S.J. Mol. Cancer Ther. (2006) [Pubmed]
  4. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. Reginato, M.J., Bailey, S.T., Krakow, S.L., Minami, C., Ishii, S., Tanaka, H., Lazar, M.A. J. Biol. Chem. (1998) [Pubmed]
  5. Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation. Ulrich, S., Wächtershäuser, A., Loitsch, S., von Knethen, A., Brüne, B., Stein, J. Exp. Cell Res. (2005) [Pubmed]
  6. The new antidiabetic drug MCC-555 acutely sensitizes insulin signaling in isolated cardiomyocytes. Liu, L.S., Tanaka, H., Ishii, S., Eckel, J. Endocrinology (1998) [Pubmed]
  7. A novel thiazolidinedione MCC-555 down-regulates tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1 in vascular endothelial cells. Kurebayashi, S., Xu, X., Ishii, S., Shiraishi, M., Kouhara, H., Kasayama, S. Atherosclerosis (2005) [Pubmed]
  8. Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat. Pickavance, L.C., Widdowson, P.S., Foster, J.R., Williams, G., Wilding, J.P. International journal of experimental pathology. (2003) [Pubmed]
  9. Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection. Sun, N., Lin, M., Fan, G., Hong, Z., Lu, G. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]
 
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