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Chemical Compound Review

AC1MHYNY     N,N'-dibuta-2,3-dienylbutane- 1,4-diamine...

Synonyms: CPC-200, AG-J-31074, ANW-54183, MDL-72527, AK-94747, ...
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Disease relevance of MDL72527


High impact information on MDL72527


Chemical compound and disease context of MDL72527


Biological context of MDL72527

  • In addition, in view of recent studies that have indicated that polyamines may influence certain oncogenes in human colonic carcinoma cells, tumors from DMH +/- MDL 72527 were analyzed for K-ras mutations [8].
  • N1,N4-di-n-butyl-1,4-butanediamine proved to be a cytotoxic agent of considerable potency, which induces mainly non-apoptotic cell death, whereas MDL 72527 causes under identical conditions both, apoptotic and non-apoptotic cell death [9].
  • At 150 micromol/L MDL 72527, SW620 cells accumulated in S-phase of the cell cycle, showed decreased polyamine transport rate, and showed no increase of polyamine N1-acetyltransferase activity [10].

Anatomical context of MDL72527

  • Exposure of the cells to MDL 72527, a compound considered to be a selective inactivator of polyamine oxidase (PAO) increased the cytotoxicity of N(1)OSSpm to both cell lines [3].
  • The increase in putrescine levels in both the traumatized and nontraumatized cortex and hippocampus was reduced by a mean of 60% with MDL 72527 treatment [11].
  • MDL 72527 (at 300 muM) produced in M14 cells numerous cytoplasmic vacuoles which, however, disappeared by 24 h, even in the presence of the drug [5].

Associations of MDL72527 with other chemical compounds


Gene context of MDL72527

  • Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells [12].
  • The observation that apple procyanidins enhance polyamine catabolism and reduce polyamine biosynthesis activity similar to known inducers of SSAT, without sharing their toxicity, and the potentiation of these effects by low concentrations of MDL 72527 suggests apple procyanidins for chemopreventive and therapeutic interventions [12].
  • Some biochemical modification of MDL 28302 and MDL 29431 appeared to be required for their inhibitory activities to be exerted, since the effects of these drugs on T. cruzi infectivity were abrogated by MDL 72527, a drug known to inhibit polyamine oxidase (PAO) activity specifically [16].
  • The polyamine oxidase inactivator MDL 72527 [17].
  • Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527 [18].


  1. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. Doğan, A., Rao, A.M., Hatcher, J., Rao, V.L., Başkaya, M.K., Dempsey, R.J. J. Neurochem. (1999) [Pubmed]
  2. Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury. Rao, A.M., Hatcher, J.F., Doğan, A., Dempsey, R.J. J. Neurochem. (2000) [Pubmed]
  3. Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity. Seiler, N., Badolo, L., Duranton, B., Vincent, F., Schneider, Y., Gossé, F., Raul, F. Int. J. Biochem. Cell Biol. (2000) [Pubmed]
  4. Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation. Moulinoux, J.P., Darcel, F., Quemener, V., Havouis, R., Seiler, N. Anticancer Res. (1991) [Pubmed]
  5. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): Sensitization by heat and MDL 72527. Agostinelli, E., Belli, F., Molinari, A., Condello, M., Palmigiani, P., Dalla Vedova, L., Marra, M., Seiler, N., Arancia, G. Biochim. Biophys. Acta (2006) [Pubmed]
  6. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. Chaturvedi, R., Cheng, Y., Asim, M., Bussière, F.I., Xu, H., Gobert, A.P., Hacker, A., Casero, R.A., Wilson, K.T. J. Biol. Chem. (2004) [Pubmed]
  7. Growth inhibition of two solid tumors in mice, caused by polyamine depletion, is not attended by alterations in cell-cycle phase distribution. Hessels, J., Kingma, A.W., Muskiet, F.A., Sarhan, S., Seiler, N. Int. J. Cancer (1991) [Pubmed]
  8. Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine. Halline, A.G., Dudeja, P.K., Jacoby, R.F., Llor, X., Teng, B.B., Chowdhury, L.N., Davidson, N.O., Brasitus, T.A. Carcinogenesis (1990) [Pubmed]
  9. Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue. Seiler, N., Renault, J., Gossé, F., Roussi, S., Raul, F. Int. J. Oncol. (2005) [Pubmed]
  10. Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620. Duranton, B., Holl, V., Schneider, Y., Carnesecchi, S., Gossé, F., Raul, F., Seiler, N. Cell Biol. Toxicol. (2002) [Pubmed]
  11. Contribution of polyamine oxidase to brain injury after trauma. Doğan, A., Rao, A.M., Baskaya, M.K., Hatcher, J., Temiz, C., Rao, V.L., Dempsey, R.J. J. Neurosurg. (1999) [Pubmed]
  12. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Gossé, F., Roussi, S., Guyot, S., Schoenfelder, A., Mann, A., Bergerat, J.P., Seiler, N., Raul, F. Int. J. Oncol. (2006) [Pubmed]
  13. Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol. Roussi, S., Goss??, F., Aoud??-Werner, D., Zhang, X., Geoffroy, P., Miesch, M., Marchioni, E., Raul, F. Int. J. Oncol. (2006) [Pubmed]
  14. Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain. Baudry, M., Najm, I. Neurosci. Lett. (1994) [Pubmed]
  15. Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention. Seiler, N., Chaabi, M., Roussi, S., Goss??, F., Lobstein, A., Raul, F. Anticancer Res. (2006) [Pubmed]
  16. N,N'-thiophene-substituted polyamine analogs inhibit mammalian host cell invasion and intracellular multiplication of Trypanosoma cruzi. Majumder, S., Kierszenbaum, F. Mol. Biochem. Parasitol. (1993) [Pubmed]
  17. The polyamine oxidase inactivator MDL 72527. Seiler, N., Duranton, B., Raul, F. Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques. (2002) [Pubmed]
  18. Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527. Agostinelli, E., Palmigiani, P., Vedova, L.D., Tempera, G., Belli, F., Seiler, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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